全文获取类型
收费全文 | 547篇 |
免费 | 22篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 17篇 |
妇产科学 | 26篇 |
基础医学 | 48篇 |
口腔科学 | 7篇 |
临床医学 | 69篇 |
内科学 | 107篇 |
皮肤病学 | 4篇 |
神经病学 | 51篇 |
特种医学 | 7篇 |
外科学 | 86篇 |
综合类 | 5篇 |
预防医学 | 61篇 |
眼科学 | 3篇 |
药学 | 49篇 |
中国医学 | 2篇 |
肿瘤学 | 28篇 |
出版年
2024年 | 3篇 |
2022年 | 2篇 |
2021年 | 8篇 |
2020年 | 9篇 |
2019年 | 12篇 |
2018年 | 10篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2015年 | 14篇 |
2014年 | 18篇 |
2013年 | 24篇 |
2012年 | 31篇 |
2011年 | 36篇 |
2010年 | 18篇 |
2009年 | 10篇 |
2008年 | 27篇 |
2007年 | 39篇 |
2006年 | 37篇 |
2005年 | 32篇 |
2004年 | 44篇 |
2003年 | 25篇 |
2002年 | 28篇 |
2001年 | 8篇 |
2000年 | 12篇 |
1999年 | 8篇 |
1998年 | 9篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 10篇 |
1990年 | 7篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1967年 | 5篇 |
1965年 | 2篇 |
1954年 | 1篇 |
1930年 | 1篇 |
排序方式: 共有570条查询结果,搜索用时 15 毫秒
81.
Margaret M. Farrell Kelsy M. Gibson Angela Marler Leslie Given Aubrey Van Kirk Villalobos Candace Deaton Maynard Frank S. Bright Ginny Thompson Kirklin Truemenda C. Green Melanie Ruhe Julia Thorsness Stephanie Weiss 《Cancer causes & control : CCC》2018,29(12):1205-1220
This paper explores how, through its extensive network of partners, the Comprehensive Cancer Control National Partnership (National Partnership) has provided a robust array of trainings, learning institutes, webinars, workshops, mentorship programs, and direct technical assistance to comprehensive cancer control programs and coalitions over the past 20 years. Mapping these activities to specific cancer control competencies revealed that the efforts of the National Partnership adequately address the core competencies necessary for an effective workforce and have the potential to increase practitioner capacity to adopt and implement evidence-based cancer control programs. Ensuring the continued availability and uptake of these tools, trainings and partnerships could potentially address gaps and barriers in the public health workforce related to evidence-based practice. 相似文献
82.
Histochemical, immunohistochemical, and ultrastructural studies of gingival fibromatosis: a case report 总被引:2,自引:0,他引:2
Ryoichi Sakamoto Tetsuya Nitta Yoshiaki Kamikawa Seishi Kono Yasuko Kamikawa Kazumasa Sugihara Shinichiro Tsuyama Fusayoshi Murata 《Medical Electron Microscopy》2002,35(4):248-254
Gingival fibromatosis is a rare disease characterized by enlargement of the gingiva. The purpose of this study was to analyze a case of idiopathic gingival fibromatosis, using histochemical and immunohistochemical staining and transmission electron microscopy. The patient was a 39-year-old Japanese man, in whom the gingiva was enlarged throughout the entire mandible and maxilla. Specimens of gingival fibromatosis exhibited epithelial hyperplasia and increased amounts of collagen fiber bundles in the connective tissue light-microscopically. Well-developed collagen bundles were strongly stained with Azan and Masson trichrome staining. Immunohistochemically, the gingival connective tissue was specifically stained by type I collagen and vimentin antibodies. Ultrastructurally, the lesion consisted of fibroblasts and mature collagen fibers running in all directions. No myofibroblasts were detected histochemically, immunohistochemically, or ultrastructurally. These findings suggested that this disease may be the result of an increase in collagen synthesis by the fibroblasts and/or that it may be associated with one of the findings of histologic heterogeneity. 相似文献
83.
84.
Y Soga H Okabayashi I Shimada S Enomoto T Morimoto Y Kamikawa Y Saito K Matsubayashi A Nagasawa 《Kyobu geka. The Japanese journal of thoracic surgery》1999,52(9):735-738
Methicillin-resistant Staphylococcus aureus from nasal discharge was identified in 37 (2.5%) cardiovascular patients operated between 1995 and 1997; 25 male and 12 female, ranging from 1 to 83 years (mean 63); 2 were excluded because of Arbekacin or Isodine-gel treatment. The first 17 were treated with Vancomycin inhalation (V group) and eradication was considered to have been achieved when 3 consecutive negative cultures were obtained; the subsequent 18 were treated with Mupirocin (M group) and eradication was determined by 1 negative culture. In post-eradication electively operated 13 V and 15 M, postoperative MRSA infection was observed in one M (wound infection); the interval from the first nasal culture to the operation was 68 +/- 58 in V and 32 +/- 12 days in M, respectively (p < 0.05). In the remaining 7 who had to undergo emergency surgery while waiting for eradication because of progression of symptoms (2 V) or prior to instituting treatment (2 V, and 3 M), postoperative MRSA infection was observed in 2 M (both pneumonia). No deaths from infection were observed. Though the time required for conversion of the nasal culture was longer in V (13 +/- 20) than in M (7 +/- 1 days) differences were not significant. Mupirocin is easier to use, eradication can be achieved generally within a week. 相似文献
85.
Chumpol Piamsomboon Gary S. Roubin Ming W. Liu Sriram S. Iyer Atul Mathur Larry S. Dean Camilo R. Gomez Jiri J. Vitek Nipon Chattipakorn Ginny Yates 《Catheterization and cardiovascular interventions》1998,45(2):139-143
Stenting of the internal carotid artery is facilitated by stenting across the carotid bifurcation and sizing the diameter of a self-expanding stent to the large common carotid segment. This usually results in marked oversizing of the self-expanding stent in the internal carotid segment. This study was done to determine the relationship between stent oversizing and late luminal loss index after stenting of the internal carotid artery. Between September 1995 and March 1997, there were 165 patients (189 vessels) who underwent successful carotid stenting with self-expanding stents. Fifty-nine patients (63 vessels) had six-month follow-up carotid angiograms and on-line quantitative angiographic analysis. The mean reference diameter of the internal carotid arteries was 4.93 ± 1.31 mm. Nominal stent size was 5 mm in 4 patients, 6 mm in 6 patients, 8 mm in 106 patients, 10 mm in 77 patients, and 12 mm in 1 patient. The average stent/patient was 1.03 ± 0.16. There were three patients who had more than 50% diameter renarrowing at follow-up. The mean late loss index was 0.25 ± 0.41. By linear regression analysis, there was no clear linear relationship between stent oversizing and late loss index after stenting (correlation coefficient = -0.21, P = 0.09). When analysis of variance with linear contrast was used to analyze six groups of different stent/artery ratios (from 1.4 to ≥ 2), late loss indexes are significantly lower in the groups of high stent/artery ratio than the groups of low stent/artery ratio (P = 0.01). The process of oversizing of self-expanding stents deployed in the internal carotid artery does not appear to be associated with late restenosis and high stent/artery ratio seems to be associated with low late loss index. Cathet. Cardiovasc. Diagn. 45:139–143, 1998. © 1998 Wiley-Liss, Inc. 相似文献
86.
Jin E. Kim-Mozeleski Janice Y. Tsoh Ginny Gildengorin Lien H. Cao Tiffany Ho Sarita Kohli Hy Lam Ching Wong Susan Stewart Stephen J. McPhee Tung T. Nguyen 《Community mental health journal》2018,54(6):748-756
Culture impacts help-seeking preferences. We examined Vietnamese Americans’ help-seeking preferences for depressive symptoms, through a telephone survey (N?=?1666). A vignette describing an age- and gender-matched individual with depression was presented, and respondents chose from a list of options and provided open-ended responses about their help-seeking preferences. Results showed that 78.3% would seek professional help, either from a family doctor, a mental health provider, or both; 54.4% preferred to seek help from a family doctor but not from a mental health provider. Most (82.1%) would prefer to talk to family or friends, 62.2% would prefer to look up information, and 50.1% would prefer to get spiritual help. Logistic regression analysis revealed that preferences for non-professional help-seeking options (such as talking to friends or family, looking up information, and getting spiritual help), health care access, and perceived poor health, were associated with increased odds of preferring professional help-seeking. This population-based study of Vietnamese Americans highlight promising channels to deliver education about depression and effective help-seeking resources, particularly the importance of family doctors and social networks. Furthermore, addressing barriers in access to care remains a critical component of promoting professional help-seeking. 相似文献
87.
Abigail Emma Russell Tamsin Ford Ginny Russell 《Social psychiatry and psychiatric epidemiology》2018,53(1):33-44
Purpose
Attention deficit/hyperactivity disorder (ADHD) is associated with socioeconomic status (SES), in that children who grow up in low SES families are at an increased risk of ADHD symptoms and diagnosis. The current study explores whether different levels of ADHD symptoms are associated with prior changes in the SES facet of financial difficulty.Methods
Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined symptoms of ADHD measured by the Strengths and Difficulties Questionnaire (SDQ) hyperactivity subscale in relation to parent-reported changes in financial difficulty, grouped into four repeated measures at four time points across childhood; (n?=?6416). A multilevel mixed-effects linear regression model with an unstructured covariance matrix was used to test whether different patterns of financial difficulty were associated with subsequent changes in ADHD symptoms.Results
Families who had no financial difficulty had children with a lower average ADHD symptom score than groups who experienced financial difficulty. Children whose families stayed in financial difficulty had higher mean ADHD symptom scores than all other groups (No difficulty mean SDQ hyperactivity 3.14, 95% CI 3.07, 3.21, In difficulty mean SDQ hyperactivity 3.39, 95% CI 3.28, 3.45, p?<?0.001). Increasing or decreasing financial difficulty predicted mean symptom scores lower than those of the in difficulty group and higher than the no difficulty group.Conclusions
Our findings contribute to the building evidence that SES may influence the severity and/or impairment associated with the symptoms of ADHD, however the effects of SES are small and have limited clinical significance.88.
Speeding up patients referrals, increasing nurses' job satisfaction and saving money have been achieved by NHS Forth Valley. 相似文献
89.
90.
Xing Y Cohen A Rothblat G Sankaranarayanan S Weibel G Royer L Francone OL Rainey WE 《Endocrinology》2011,152(3):751-763
Adrenal aldosterone production is regulated by physiological agonists at the level of early and late rate-limiting steps. Numerous studies have focused on the role of lipoproteins including high-density lipoprotein (HDL) as cholesterol providers in this process; however, recent research suggests that HDL can also act as a signaling molecule. Herein, we used the human H295R adrenocortical cell model to study the effects of HDL on adrenal aldosterone production and CYP11B2 expression. HDL, especially HDL2, stimulated aldosterone synthesis by increasing expression of CYP11B2. HDL treatment increased CYP11B2 mRNA in both a concentration- and time-dependent manner, with a maximal 19-fold increase (24 h, 250 μg/ml of HDL). Effects of HDL on CYP11B2 were not additive with natural agonists including angiotensin II or K(+). HDL effects were likely mediated by a calcium signaling cascade, because a calcium channel blocker and a calmodulin kinase inhibitor abolished the CYP11B2-stimulating effects. Of the two subfractions of HDL, HDL2 was more potent than HDL3 in stimulating aldosterone and CYP11B2. Further studies are needed to identify the active components of HDL, which regulate aldosterone production. 相似文献