收费全文 | 391篇 |
免费 | 24篇 |
国内免费 | 3篇 |
耳鼻咽喉 | 3篇 |
儿科学 | 6篇 |
妇产科学 | 8篇 |
基础医学 | 42篇 |
口腔科学 | 36篇 |
临床医学 | 22篇 |
内科学 | 64篇 |
皮肤病学 | 9篇 |
神经病学 | 46篇 |
特种医学 | 12篇 |
外科学 | 91篇 |
综合类 | 7篇 |
预防医学 | 18篇 |
眼科学 | 2篇 |
药学 | 39篇 |
中国医学 | 2篇 |
肿瘤学 | 11篇 |
2024年 | 1篇 |
2023年 | 7篇 |
2022年 | 14篇 |
2021年 | 11篇 |
2020年 | 11篇 |
2019年 | 12篇 |
2018年 | 17篇 |
2017年 | 15篇 |
2016年 | 17篇 |
2015年 | 17篇 |
2014年 | 21篇 |
2013年 | 16篇 |
2012年 | 33篇 |
2011年 | 25篇 |
2010年 | 13篇 |
2009年 | 13篇 |
2008年 | 27篇 |
2007年 | 30篇 |
2006年 | 23篇 |
2005年 | 12篇 |
2004年 | 12篇 |
2003年 | 5篇 |
2002年 | 7篇 |
2001年 | 6篇 |
2000年 | 6篇 |
1999年 | 2篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1969年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
Background:
Perimembranous Ventricular Septal Defect (PMVSD) is the most common subtype of ventricular septal defects. Transcatheter closure of PMVSD is a challenging procedure in management of moderate or large defects.Objectives:
The purpose of this study was to show that transcatheter closure of perimembranous ventricular septal defect with Amplatzer Ductal Occluder (ADO) is an effective and safe method.Patients and Methods:
Between April 2012 and April 2013, 28 patients underwent percutaneous closure of PMVSD using ADO. After obtaining the size of VSD from the ventriculogram a device at least 2 mm larger than the narrowest diameter of VSD at right ventricular side was chosen. The device deployed after confirmation of its good position by echocardiography and left ventriculography. Follow up evaluations were done 1 month, 6 months, 12 months and yearly after discharge with transthoracic echocardiography and 12 lead electrocardiography.Results:
The mean age of patients at procedure was 4.7 ± 6.3 (range 2 to 14) years, mean weight 14.7 ± 10.5 (range 10 to 40) kg. The mean defect size of the right ventricular side was 4.5 ± 1.6 mm. The average device size used was 7.3 ± 3.2mm (range 4 to 12 mm). The ADOs were successfully implanted in all patients. The VSD occlusion rate was 65.7% at completion of the procedure, rising up to 79.5% at discharge and 96.4% during follow-up. Small residual shunts were seen at completion of the procedure, but they disappeared during follow-up in all but one patient. The mean follow-up period was 8.3 ± 3.6 months (range 1 to 18 months). Complete atrioventricular block (CAVB), major complication or death was not observed in our study.Conclusions:
Transcatheter closure of PMVSD with ADO in children is a safe and effective treatment associated with excellent success and closure rates, but long-term follow-up in a large number of patients would be warranted. 相似文献Methods: AT patients were categorized according to the ability of class switching and patients with hyper IgM (HIgM) profile were defined as class switching defect (CSD).
Results: Serum immunoglobulin profile in 66 AT patients showed normal immunoglobulin level (22.8%), IgA deficiency (37.9%) and hypogammaglobulinemia (18.1%) in the majority of patients, while 21.2% had HIgM profile revealing CSD. CSD does not affect the frequency of infections, however, the frequency of lymphoproliferation (p < 0.001), and autoimmunity (p = 0.004) were significantly higher in this group. Neurologic symptoms in CSD patients are mild or appear after recurrent infections, therefore these patients were usually misdiagnosed as HIgM syndrome.
Conclusions: Although most of AT patients have reduced IgA levels or normal immunoglobulin levels, but a fraction of these patients may show CSD ensuing HIgM-profile. CSD poses affected individuals at higher risk of non-infectious complications. 相似文献