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31.
The techniques of surgery for head injury have evolved from an emphasis on exploration for diagnosis to a focus on decompression, maintenance of adequate perfusion, restoration of anatomic integrity, prevention of complications, and preservation of cosmesis. 相似文献
32.
Hopwood P Fletcher I Lee A Al Ghazal S 《European journal of cancer (Oxford, England : 1990)》2001,37(2):189-197
Body image is an important endpoint in quality of life evaluation since cancer treatment may result in major changes to patients' appearance from disfiguring surgery, late effects of radiotherapy or adverse effects of systemic treatment. A need was identified to develop a short body image scale (BIS) for use in clinical trials. A 10-item scale was constructed in collaboration with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Study Group and tested in a heterogeneous sample of 276 British cancer patients. Following revisions, the scale underwent psychometric testing in 682 patients with breast cancer, using datasets from seven UK treatment trials/clinical studies. The scale showed high reliability (Cronbach's alpha 0.93) and good clinical validity based on response prevalence, discriminant validity (P<0.0001, Mann-Whitney test), sensitivity to change (P<0.001, Wilcoxon signed ranks test) and consistency of scores from different breast cancer treatment centres. Factor analysis resulted in a single factor solution in three out of four analyses, accounting for >50% variance. These results support the clinical validity of the BIS as a brief questionnaire for assessing body image changes in patients with cancer, suitable for use in clinical trials. 相似文献
33.
M. Soufi M. K. Lahlou O. Benzekri F. Ghazal R. Massrouri S. Benamr A. Essadel J. Mdaghri El H. Mohammadine A. Taghy A. Settaf B. Chad 《Journal africain du cancer / African Journal of Cancer》2009,1(2):93-97
Liposarcoma represent the single most common type of soft tissue sarcoma. Its abdominal localization is rare, occurring in only 5% of cases. A 60-year-old male was found to have a case of primary multiple liposarcoma of the mesentery and mesocolon. Computed tomography revealed the presence of a peritoneal mass presenting a homogeneous density with an adipose component. Preoperative biopsies were falsely reassuring. A laparotomy confirmed the presence of multiple tumors in the mesentery and the mesocolon. The masses were removed and the histopathological report noted a well-differentiated liposarcoma. Chemotherapy was prescribed. The patient was well at 18 months follow-up. Surgery currently represents the best curative therapy for this type of tumor. Chemotherapy seems promising in liposarcoma. Diagnostic and therapeutic problems related to this type of neoplasm as well as a literature reviews are reported. 相似文献
34.
Harald Renz Becky D. Adkins Sina Bartfeld Richard S. Blumberg Donna L. Farber Johan Garssen Peter Ghazal David J. Hackam Benjamin J. Marsland Kathy D. McCoy John Penders Immo Prinz Valerie Verhasselt Erika von Mutius Jeffrey N. Weiser Duane R. Wesemann Mathias W. Hornef 《The Journal of allergy and clinical immunology》2018,141(4):1212-1214
35.
Acquired torsade de pointes ventricular tachycardia (TdP) is a rare but serious life-threatening arrhythmia caused by an array of cardiac and non-cardiac drugs. It is often refractory to pharmacological therapy and may result in death or require frequent defibrillations. In our case study a young female patient with no underlying heart disease developed very frequent sustained TdP requiring frequent defibrillations without which she would have certainly died. The ventricular arrhythmia in this patient was of multifactorial origin – cisapride, drug–drug interaction and persistent vomiting resulting in electrolyte disturbance and malnutrition. The patient survived after more than 300 defibrillation shocks over a period of 5 days and she is still alive 12 years later. 相似文献
36.
Hariri G Wellons MS Morris WH Lukehart CM Hallahan DE 《Annals of biomedical engineering》2011,39(3):946-952
A multifunctional FePt nanoparticle was developed that targets tumor microvasculature via “radiation-guided” peptides, and
is detected by both near-infrared (NIR) fluorescence imaging and analytical mass spectrometry methods. Tumor specific binding
was first measured by biotinylated peptide linked to fluorophore-conjugated streptavidin. This showed tumor selective binding
to tumors using the HVGGSSV peptide. FePt nanoparticles were synthesized sequentially by surface modification with poly(l)lysine, poly(ethylene) glycol conjugation, and functionalized with HVGGSSV peptide and fluorescent probe Alexa fluor 750.
NIR fluorescence imaging and ICP-MS analysis showed significant HVGGSSV-FePt nanoparticle binding to irradiated tumors as
compared to unirradiated tumors and controls. Results indicate that multifunctional FePt nanoparticles have potential application
for radiation-guided targeting and imaging of cancer. 相似文献
37.
Callewaere C Banisadr G Rostène W Parsadaniantz SM 《Journal of molecular endocrinology》2007,38(3):355-363
Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells both in vivo and in vitro. In addition to their well-established role in the immune system, several recent reports have suggested that chemokines and their receptors may also play a role in the central nervous system (CNS). The best known central action is their ability to act as immunoinflammatory mediators. Indeed, these proteins regulate leukocyte infiltration in the brain during inflammatory and infectious diseases. However, we and others recently demonstrated that they are expressed not only in neuroinflammatory conditions, but also constitutively by different cell types including neurons in the normal brain, suggesting that they may act as modulators of neuronal functions. The goal of this review is to highlight the role of chemokines in the control of neuroendocrine functions. First, we will focus on the expression of chemokines and their receptors in the CNS, with the main spotlight on the neuronal expression in the hypothalamo-pituitary system. Secondly, we will discuss the role--we can now suspect--of chemokines and their receptors in the regulation of neuroendocrine functions. In conclusion, we propose that chemokines can be added to the well-described neuroendocrine regulatory mechanisms, providing an additional fine modulatory tuning system in physiological conditions. 相似文献
38.
39.
Drugs in the gastrointestinal tract are exposed to a medium of partially digested food, comprising mixtures of fat, protein and carbohydrate. The dissolution behaviour of itraconazole was evaluated in bio-relevant media which were developed to take this into account. Media containing milk with different fat contents, protein (albumin, casein, gluten and gelatin), carbohydrates (glucose, lactose and starch) and amino acids (lysine, glycine, alanine and aspartic acid) to mimic a digested meal and bile components (sodium taurocholate and lecithin) to represent a key endogenous digestive material were investigated. The effect of medium composition on the intrinsic dissolution rate of itraconazole was evaluated as this drug has extremely poor solubility and its bioavailability is affected by food. Dissolution tests were carried out in simple compendial media based on dilute solutions of hydrochloric acid or neutral solutions of phosphate buffer and in more complex media containing the dietary components. The data obtained showed that most of the dietary components enhanced the solubility compared to simulated gastric fluid (SGF) but to differing extents. The greatest increase in dissolution was observed with the addition of milk and albumin although an increase was also seen with other proteins, amino acids and simulated gastrointestinal fluids. 相似文献
40.