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71.
Giangennaro Coppola Alessandra D’Amico Erica Pironti Federica Martino Elena Santoro Nilde Di Paolo Claudia Isone Gennaro Catone 《Brain & development》2014
We report the case of a 11-year-old girl who developed an isolated hand-writing disorder with dysgraphia at the beginning of the school year in the sixth grade. A brain magnetic resonance angiography showed a round arteriovenous malformation sited in the left side of the midbrain extending to the ipsilateral medio-basal thalamus. Child neurologists should never neglect a thorough neurological evaluation in case of isolated worsening of handwriting, to rule out possible underlying organic causes. 相似文献
72.
Francesco Ardito Vincenzo Arena Maria Vellone Gennaro Grande Ilaria Pennacchia Francesco Majellaro Ivo Giovannini Fabio M. Vecchio Gennaro Nuzzo Felice Giuliante 《Journal of gastrointestinal surgery》2014,18(11):1987-1993
Introduction
The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection.Materials and Methods
Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for CRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity).Results
YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8 %) and strong in 49 patients (74.2 %). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1 vs. 23.5 % (p?=?0.023). Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk factor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0 % in the weak expression group and 41.5 % in the strong expression group (p?=?0.034). These results were not influenced by clinical prognostic factors of tumor recurrence.Conclusions
This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver recurrence following liver resection. 相似文献73.
Daniela Braida Luisa Ponzoni Roberta Martucci Fabio Sparatore Cecilia Gotti Mariaelvina Sala 《Psychopharmacology》2014,231(9):1975-1985
Rationale
Neuronal nicotinic acetylcholine receptors (nAChRs) play a modulatory role in cognition, and zebrafish provide a preclinical model to study learning and memory.Objectives
We investigated the effect of nicotine (NIC) and some new cytisine-derived partial agonists (CC4 and CC26) on spatial memory in zebrafish using a rapid assay on T-maze task. The role of α4/α6β2 and the α7 nAChRs in NIC-induced memory enhancement was evaluated using selective nAChR antagonists.Results
Low and high doses of NIC, cytisine (CYT), CC4 and CC26 respectively improved and worsened the mean running time, showing an inverted U dose–response function. The effective dose (ED50) (×10?5 mg/kg) was 0.4 for CC4, 4.5 for CYT, 140 for NIC and 200 for CC26. NIC-induced cognitive enhancement was reduced by the selective nAChR subtype antagonists: methyllycaconitine (MLA) for α7, α-conotoxin (MII) for α6β2, dihydro-β-erythroidine (DhβE) for α4β2, the nonselective antagonist mecamylamine (MEC) and the muscarinic antagonist scopolamine (SCOP), with DhβE being more active than MLA or MII. All the partial agonists blocked the cognitive enhancement. The improvement with the maximal active dose of each partial agonist was blocked by low doses of DhβE (0.001 mg/kg) and MII (0.01 mg/kg). MLA reduced the effects of CC26 and CC4 at doses of 0.01 and 1 mg/kg, respectively, but did not antagonize CYT-induced memory improvement at any of the tested dose. No change in swimming activity was observed.Conclusions
Our findings demonstrate that zebrafish make a useful model for the rapid screening of the effect of new α4β2 nAChR compounds on spatial memory. 相似文献74.
Giuseppe Tarantini MD Giulia Masiero MD Francesco Burzotta MD Vittorio Pazzanese MD Carlo Briguori MD Carlo Trani MD Tommaso Piva MD Federico De Marco MD Maurizio Di Biasi MD Paolo Pagnotta MD Marco Mojoli MD Gavino Casu MD Gennaro Giustino MD Giulia Lorenzoni PhD Matteo Montorfano MD Marco B. Ancona MD Federico Pappalardo MD Alaide Chieffo MD IMPella Mechanical Circulatory Support Device in Italy Registry authors 《Catheterization and cardiovascular interventions》2021,98(2):E222-E234
75.
Francesco Giannini MD Matteo Pagnesi MD Gianluca Campo MD PhD Michael Donahue MD Luca A. Ferri MD Carlo Briguori MD PhD Giulio G. Stefanini MD PhD Raffaele Scardala MD Gennaro Sardella MD Salvatore De Rosa MD PhD Filippo Figini MD Alberto Monello MD Luigi E. Pastormerlo MD Luca Testa MD PhD Annamaria Nicolino MD Alfonso Ielasi MD Alessandro Durante MD Angelo Leone MD Giorgios Tzanis MD Antonio Mangieri MD Giovanni Ciccarelli MD Martina Briani MD Bernhard Reimers MD Andrea Ceccacci MD Ciro Indolfi MD Imad Sheiban MD Cataldo Palmieri MD Francesco Bedogni MD Maurizio Tespili MD Azeem Latib MD Francesco Gallo Antonio Colombo MD 《Catheterization and cardiovascular interventions》2021,97(3):411-420
76.
Prediction of postoperative pulmonary function following thoracic surgery for bronchial carcinoma. 总被引:1,自引:0,他引:1
At present surgery is accepted as the most effective mode of therapy for carcinoma of the lung. Because the lack of respiratory reserve is the major determinant of postoperative function, it is useful to identify the patient, who is at significant risk. Eighteen patients with lung cancer (mean age = 56 +/- 6.5 years) were studied preoperatively (preop) and postoperative (postop) (three to four months after lung resection) by spirometry, measurement of arterial blood gases, and quantitative lung scanning (99mTc). A predicted postoperative value of some variables was calculated by the formula: postop value = preop value x % function of regions of lung not resected. The correlation coefficient between the predicted (pred) and postoperatively observed (observ) values VC = vital capacity, FEV1 = forced expiratory volume in 1 second) is: VC pred/VC observ r = 0.83 p less than 0.001 FEV1 pred/FEV1 observ r = 0.82 p less than 0.001. The authors' results agree with earlier reports and show that the method used can accurately predict the postoperative respiratory function in patients undergoing lung resection (pneumonectomy or lobectomy). A predicted FEV1 of 0.8 L does not permit a surgical program, because, below this level, carbon dioxide retention becomes more frequent and exercise intolerance is increasingly severe (poor quality of life). The method proposed to predict the postoperative respiratory function is simple and routinely useful. The authors choose a perfusion instead of ventilation scan, because the former provides similar predicted postoperative data, and can be done routinely. 相似文献
77.
78.
79.
Raffaele Piccolo Gennaro Galasso Giuseppe De Luca Guido Parodi David Antoniucci Giovanni Esposito Bruno Trimarco Federico Piscione 《Atherosclerosis》2014
Objective
High on-treatment platelet reactivity (HPR) is a well-known risk factor for adverse events in patients undergoing percutaneous coronary intervention (PCI). However, whether reducing platelet reactivity can lead to a lower incidence of ischemic events after PCI is still controversial. Therefore, we sought to investigate this issue by a meta-regression analysis of randomized trials.Methods
We collected randomized trials reporting HPR rates in patients receiving different antiplatelet therapies. ΔHPR was defined as the difference between HPR rates achieved in control vs. experimental arms, and the relationship between ΔHPR and clinical outcomes was evaluated.Results
Thirty trials totalling 6683 patients with a mean follow-up of 3-month were included. Reducing platelet reactivity was associated to a decreased risk of major adverse cardiac events (MACE), with a linear relationship between ΔHPR and MACE (change in tau2 = −2.50; p = 0.023). Particularly, achieving a 10% difference in HPR rates resulted in a parallel risk reduction in MACE of about 11% (Exp(b) = 0.98; 95% CI, 0.97–0.99).Changes in HPR predict the risk of ischemic events in patients with acute coronary syndrome (change in tau2 = −2.52; Exp(b) = 0.98; 95% CI, 0.97–0.99; p = 0.03), but not in patients with poor response to clopidogrel (change in tau2 = −1.44; Exp(b) = 0.98; 95% CI, 0.96–1.01; p = 0.19) or stable coronary artery disease (change in tau2 = −0.14; Exp(b) = 0.99; 95% CI, 0.94–1.05; p = 0.89).Conclusion
Reducing HPR occurrence decreases the risk of ischemic events in patients with acute coronary syndrome undergoing PCI, whereas a strategy of reducing platelet reactivity does not improve clinical outcomes in patients with poor response to clopidogrel or stable coronary artery disease. 相似文献80.