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61.
Matteo Fosco Luca Amendola Rossana Fantasia Gennaro Pipino Domenico Tigani 《European orthopaedics and traumatology》2013,4(3):131-136
Background
Tantalum-made cones have been developed to compensate for large bone defect involving metaphyseal segment or major portion of the condyle or plateau during knee revision prosthetic surgery.Materials and methods
We present our experience with femoral and tibial tantalum cones in 11 knees (12 cones overall were used, 6 on femur and 6 on tibia) with 2B or 3 Engh defect type during knee revision arthroplasty. Both cemented and cementless cones were used. Patients were submitted to a specific study protocol in order to exclude a new or persistent infection. Only one intra-operative complication not related to the implantation of the trabecular metal cone was observed.Results
Neither early nor late post-operative re-infection was reported in our series at a mean follow-up of 39.8 months. Radiological analysis showed no cases of aseptic loosening or migration of the components. The only post-operative complication was delayed union of the tibial tuberosity in a patient who required osteotomy for surgical exposure. All patients improved both clinically and functionally.Conclusions
The results of this study support the use of femoral and tibial porous tantalum metaphyseal cones as a viable option for revision knee arthroplasty with large amount of bone defects in both tibia and femur. We think that the main advantages of tantalum cones compared to structural bone graft lie in faster full weight-bearing recovery and in the cones' potential long-term maintenance of mechanical support. By our results, we can eventually exclude any concern regarding a possible direct correlation of the trabecular metal cones with re-infection. 相似文献62.
63.
Giuseppe Rengo Gennaro Pagano Dino Franco Vitale Roberto Formisano Klara Komici Laura Petraglia Valentina Parisi Grazia Daniela Femminella Claudio de Lucia Stefania Paolillo Alessandro Cannavo Emilio Attena Teresa Pellegrino Santo Dellegrottaglie Alessia Memmi Bruno Trimarco Alberto Cuocolo Pasquale Perrone Filardi Dario Leosco Nicola Ferrara 《European journal of nuclear medicine and molecular imaging》2016,43(13):2392-2400
Purpose
Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. Importantly, SNS hyperactivity characterizes also physiological ageing, and there is conflicting evidence on cardiac 123I-mIBG uptake in healthy elderly subjects compared to adults. However, little data are available on the impact of ageing on cardiac sympathetic nerve activity assessed by 123I-mIBG scintigraphy, in patients with HF.Methods and results
We studied 180 HF patients (age?=?66.1?±?10.5 years [yrs]), left ventricular ejection fraction (LVEF?=?30.6?±?6.3 %) undergoing cardiac 123I-mIBG imaging. Early and late heart to mediastinum (H/M) ratios and washout rate were calculated in all patients. Demographic, clinical, and echocardiographic data were also collected. Our study population consisted of 53 patients aged >75 years (age?=?77.7?±?4.0 year), 67 patients aged 62–72 years (age?=?67.9?±?3.2 years) and 60 patients aged ≤61 year (age?=?53.9?±?5.6 years). In elderly patients, both early and late H/M ratios were significantly lower compared to younger patients (p?<?0.05). By multivariate analysis, H/M ratios (both early and late) and washout rate were significantly correlated with LVEF and age.Conclusions
Our data indicate that, in a population of HF patients, there is an independent age-related effect on cardiac SNS innervation assessed by 123I-mIBG imaging. This finding suggests that cardiac 123I-mIBG uptake in patients with HF might be affected by patient age.64.
Inbal Samuk Akin Tekin Panagiotis Tryphonopoulos Ignacio G. Pinto Jennifer Garcia Debbie Weppler David M. Levi Seigo Nishida Gennaro Selvaggi Phillip Ruiz Andreas G. Tzakis Rodrigo Vianna 《Pediatric surgery international》2016,32(4):337-346
Purpose
To present our experience in abdominal transplantations to manage unresectable abdominal neoplasms in children and to describe the role of extensive surgeries in such cases.Methods
This is a retrospective study of 22 abdominal transplantations in 21 patients for abdominal tumors over 16 years. Transplantation techniques included liver transplant (LT), multivisceral transplant (MVTx), and intestinal autotransplant (IA). Follow-up intervals ranged from 0.3 to 168 months (median 20 months).Results
LT alone was performed in 15 patients for primary malignant (11) and benign (4) liver tumors. Pathological classification included HB hepatoblastoma (6), HCC hepatocellular cancer (3), hepatic epithelioid hemangioendothelioma HEH (1), angiosarcoma (1), benign vascular tumors (3), and adenoma (1). IA was performed in four patients for lesions involving the root of the mesentery; tumors of the head of pancreas (3) and mesenteric hemangioma (1). MVTx was performed in 2 patients for malignancies; pancreaticoblastoma (1), recurrent hepatoblastoma (1), and in one patient as a rescue procedure after IA failure. Four of the eleven patients who underwent LT for malignant liver tumor had metastatic disease at presentation. Six of them died of recurrent neoplasm (3), transplant-related complications (2), and underlying disease (1). All LT patients who had benign tumors are alive with functioning grafts. All IA patients survived and are on an oral diet, with one patient requiring TPN supplementation. One of the three patients who underwent MVTx died of metastatic disease.Conclusions
Allo/auto transplantation for abdominal tumors is a valuable modality when conventional treatments fail or are not feasible.65.
Robotic approach using simple and radical hysterectomy for endometrial cancer with long‐term follow‐up evaluation 下载免费PDF全文
66.
67.
Slow eye movements and subjective estimates of sleepiness predict EEG power changes during sleep deprivation 总被引:1,自引:0,他引:1
Marzano C Fratello F Moroni F Pellicciari MC Curcio G Ferrara M Ferlazzo F De Gennaro L 《Sleep》2007,30(5):610-616
RATIONALE: The aim of the present study was to assess, intraindividually, the relationship among slow eye movements, electroencephalogram (EEG) power, and subjective measures of sleepiness during a 40-hour sleep deprivation comparing 2 experimental conditions: eyes-open and eyes-closed. METHODS: Nineteen normal subjects participated in a sleep-deprivation protocol with recordings of the waking Cz-A1-2 EEG in 36 sessions at 1-hour intervals starting at 10:00 AM. Each session consisted of a 2-minute eyes-closed period, followed by a 4-minute eyes-open period. Electrooculogram, self-ratings (Karolinska Sleepiness Scale and Visual Analog Scale for Global Vigor), and tympanic temperature were also recorded. RESULTS: Changes in sleepiness and alertness are paralleled by increases in slow eye movements and theta and delta EEG power. The beginning of the rise of delta, theta, and slow eye movement activity corresponded to the nadir of temperature, peaking at 7:00AM. Cross-correlational analyses showed that changes in slow eye movements were strictly phase locked to those in slow-frequency EEG bands and in subjective measures. The comparison of time intervals that were equivalent with respect to circadian phase confirms the effects of the increased sleepiness on slow eye movement activity and on the other measures. The temporal concordance of the different physiologic and subjective measures is also reflected in the individual time courses. Individual and group analyses converged in indicating that slow eye movements can be considered reliable indexes of sleepiness but only in the eyes-closed condition. CONCLUSIONS: Results suggest that subjective and EEG changes associated with higher sleepiness are paralleled by an increase in slow eye movement activity, but this relationship exists almost exclusively with the eyes closed. Hence, its use in practical and operational contexts seems limited. 相似文献
68.
Liccardi G D'Amato G 《The Journal of allergy and clinical immunology》2007,119(3):756; author reply 756-756; author reply 757
69.
Manzoni P Stolfi I Pugni L Decembrino L Magnani C Vetrano G Tridapalli E Corona G Giovannozzi C Farina D Arisio R Merletti F Maule M Mosca F Pedicino R Stronati M Mostert M Gomirato G;Italian Task Force for the Study Prevention of Neonatal Fungal Infections;Italian Society of Neonatology 《The New England journal of medicine》2007,356(24):2483-2495
70.
Stefano Luzzago Ottavio de Cobelli Gabriele Cozzi Giulia Peveri Vincenzo Bagnardi Michele Catellani Ettore Di Trapani Francesco A. Mistretta Paola Pricolo Andrea Conti Sarah Alessi Giulia Marvaso Matteo Ferro Deliu-Victor Matei Giuseppe Renne Barbara Alicja Jereczek-Fossa Giuseppe Petralia Gennaro Musi 《BJU international》2020,126(1):104-113