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Rasim Gen?osmano?lu Orhan Sad Aydin Sav Nurdan T?zün 《The Turkish journal of gastroenterology》2002,13(3):175-179
A 66-year-old male was admitted with a two-month history of vomiting and weight loss. Endoscopy showed a pyloric obstruction and the patient underwent subtotal gastrectomy with gastro- jejunostomy. The histopathological study of the specimen revealed primary hypertrophic pyloric stenosis without any evidence of duodenal peptic disease. In the adult, this is a rare cause of gastric outlet obstruction of unknown etiology. It is usually recognized by histopathological examination of the specimen after a gastric resection performed to treat gastric outlet obstruction syndrome. However, some endoscopic and radiological signs, such as the cervix sign, or elongation of the pyloric channel, may give clues about the presence of the disease preoperatively. In symptomatic cases, surgery is the preferred treatment modality. 相似文献
94.
Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients 总被引:2,自引:0,他引:2
Taniguchi A Fukushima M Nakai Y Kuroe A Yamano G Yanagawa T Ohgushi M Ohya M Yoshii S Taki Y Seino Y 《Metabolism: clinical and experimental》2005,54(3):376-380
The aim of the present study was to investigate the relationships between insulin resistance and soluble E-selectin, body mass index (BMI), leptin, and serum lipid profile including triglycerides in nonobese Japanese type 2 diabetic patients. A total of 97 nonobese Japanese type 2 diabetic patients aged 43 to 84 years were examined. The duration of diabetes was 11.2 +/- 0.8 years. In conjunction with BMI and fasting concentrations of plasma glucose, serum lipids (triglycerides, total cholesterol, and high-density lipoprotein cholesterol) and serum insulin, soluble E-selectin, and leptin were also measured. The low-density lipoprotein (LDL) cholesterol level was calculated using the Friedewald formula. Insulin resistance was estimated by the homeostasis model assessment. The subjects were divided into 2 groups according to the value of insulin resistance estimated by the homeostasis model assessment. Values greater than 2.5 were indicative of the insulin-resistant state, and values less than 2.5 were indicative of the insulin-sensitive state. The insulin-resistant group had significantly higher levels of E-selectin, leptin, triglycerides, total and LDL cholesterol, and diastolic blood pressure as compared with the insulin-sensitive group. There was, however, no significant difference in age, sex, diabetes duration, BMI, systolic blood pressure, HbA1c, and high-density lipoprotein cholesterol between the 2 groups. Univariate regression analysis showed that insulin resistance was positively correlated to E-selectin (r = 0.305, P = .003), BMI (r = 0.283, P = .006), leptin (r = 0.296, P = .004), HbA1c (r = 0.241, P = .018), serum triglycerides (r = 0.385, P < .001), serum total (r = 0.240, P = .019) and LDL cholesterol (r = 0.254, P = .013) levels, and systolic (r = 0.247, P = .024) and diastolic (r = 0.305, P = .006) blood pressure. Multiple regression analyses showed that insulin resistance was independently predicted by serum E-selectin (F = 18.4), serum leptin (F = 14.0) and serum triglycerides (F = 20.0) levels, which explained 45.0% of the variability of insulin resistance. From these results, it can be concluded that in conjunction with serum triglycerides and serum leptin, serum E-selectin is another important independent factor associated with insulin resistance in nonobese Japanese type 2 diabetic patients. 相似文献
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Sun Xu Lu Wei Zhao Dianhui Gen Daoying Shen Tianzhen Chen Xingrong 《Journal of digestive diseases》2001,2(2):74-77
OBJECTIVE : To investigate the computed tomography (CT) virtual colographic features of colonic polyps, colorectal cancer, diverticula, ulcerative colitis and other benign colonic lesions. Also, to assess the value of this method in the diagnosis of colorectal lesions. METHODS : Computed tomography colography was performed in 37 patients (26 male, 11 female) suffering from the following conditions: 20 colonic adenomas, six colon cancers, four diverticula, five ulcerative colitis and one each of melanosis coli and amyloidosis. The data from CT scanning were processed by computer with specific software and the colonic lesions were evaluated with 2‐ or 3‐D images, depending on the individual software. RESULTS : Seventeen cases of colonic adenoma, six colon cancers, four diverticula and two cases of ulcerative colitis were detected by using CT colography. However, melanosis coli and amyloidosis of the colon were not detected. CONCLUSION : Computed tomography colography can detect all colonic polyps of 0.5 cm in diameter or larger, colon cancer, diverticula and some ulcerative colitis successfully. It is quick, minimally invasive and able to be tolerated well. It has the potential to become an effective radiological tool in diagnosing colonic lesions. 相似文献
96.
To examine the role of thyroid hormones in the seasonal breeding cycle in Japanese monkeys (Macaca fuscata fuscata), sexually mature females were thyroidectomized (n=6) in early December, during the midbreeding season, or they received sham operations (n=4). They were housed indoors individually, and blood samples were collected two to three times a week to monitor gonadotropin
and gonadal steroid hormone secretions. Control monkeys exhibited ovulatory cycles during the breeding season. The mean dates
of onset and end of the ovulatory cycles were October 22±13 d and February 25±14 d, respectively. These dates coincided well
with those of our colonies under captivity. By contrast, three of the six thyroidectomized monkeys terminated ovulatory cycles
immediately after operations; the remaining three monkeys ovulated only once or twice after thyroid removal. The mean dates
of onset and end of the ovulatory cycles of thyroidectomized monkeys were October 18±4 d and December 31±4 d, respectively.
This was a significantly earlier termination of the ovulatory cycles than in controls. Mean concentrations of plasma thyroxine
of control monkeys were maintained throughout the experimental period, whereas plasma thyroxine concentrations of thyroidectomized
monkeys decreased abruptly to undetectable levels. Thyroidectomized monkeys exhibited significantly higher levels of plasma
prolactin (PRL) than controls. Moreover, even in control monkeys, plasma PRL increased during the transition out of the breeding
season. These results suggest that thyroid hormones play an important role in the regulation of ovulatory cycles in Japanese
monkeys, directory or indirectly, possibly by mediating the changes of PRL secretion. 相似文献
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Su Jinmei Li Mengtao He Lan Zhao Dongbao Wan Weiguo Liu Yi Xu Jianhua Xu Jian Liu Huaxiang Jiang Lindi Wu Huaxiang Zuo Xiaoxia Huang Cibo Liu Xiumei Li Fen Zhang Zhiyi Liu Xiangyuan Dong Lingli Li Tianwang Chen Haiying Li Jingyang He Dongyi Lu Xin Huang Anbin Tao Yi Wang Yanyan Zhang Zhuoli Wei Wei Li Xiaofeng Zeng Xiaofeng 《Clinical rheumatology》2022,41(3):731-739
Clinical Rheumatology - The equivalence of the biosimilar HS016 to adalimumab (Humira) for the treatment of active ankylosing spondylitis (AS) patients has been previously validated. The aim was to... 相似文献
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