全文获取类型
收费全文 | 3137篇 |
免费 | 236篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 70篇 |
妇产科学 | 48篇 |
基础医学 | 451篇 |
口腔科学 | 56篇 |
临床医学 | 348篇 |
内科学 | 787篇 |
皮肤病学 | 14篇 |
神经病学 | 301篇 |
特种医学 | 102篇 |
外科学 | 316篇 |
综合类 | 35篇 |
一般理论 | 1篇 |
预防医学 | 217篇 |
眼科学 | 54篇 |
药学 | 243篇 |
中国医学 | 6篇 |
肿瘤学 | 316篇 |
出版年
2023年 | 29篇 |
2022年 | 46篇 |
2021年 | 80篇 |
2020年 | 52篇 |
2019年 | 84篇 |
2018年 | 75篇 |
2017年 | 49篇 |
2016年 | 73篇 |
2015年 | 97篇 |
2014年 | 130篇 |
2013年 | 149篇 |
2012年 | 281篇 |
2011年 | 257篇 |
2010年 | 130篇 |
2009年 | 118篇 |
2008年 | 189篇 |
2007年 | 225篇 |
2006年 | 195篇 |
2005年 | 228篇 |
2004年 | 165篇 |
2003年 | 185篇 |
2002年 | 141篇 |
2001年 | 23篇 |
2000年 | 30篇 |
1999年 | 36篇 |
1998年 | 47篇 |
1997年 | 34篇 |
1996年 | 26篇 |
1995年 | 18篇 |
1994年 | 26篇 |
1993年 | 17篇 |
1992年 | 15篇 |
1991年 | 6篇 |
1990年 | 9篇 |
1989年 | 7篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1984年 | 4篇 |
1983年 | 9篇 |
1982年 | 4篇 |
1980年 | 5篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1975年 | 7篇 |
1974年 | 5篇 |
1973年 | 6篇 |
1971年 | 4篇 |
1968年 | 6篇 |
1967年 | 3篇 |
1964年 | 3篇 |
排序方式: 共有3381条查询结果,搜索用时 0 毫秒
31.
Genomewide profiling of copy‐number alteration in monoclonal gammopathy of undetermined significance 下载免费PDF全文
Aneta Mikulasova Jan Smetana Marketa Wayhelova Helena Janyskova Viera Sandecka Zuzana Kufova Martina Almasi Jiri Jarkovsky Evzen Gregora Petr Kessler Marek Wrobel Brian A. Walker Christopher P. Wardell Gareth J. Morgan Roman Hajek Petr Kuglik 《European journal of haematology》2016,97(6):568-575
Monoclonal gammopathy of undetermined significance (MGUS) is a benign condition with an approximate 1% annual risk of symptomatic plasma cell disorder development, mostly to multiple myeloma (MM). We performed genomewide screening of copy‐number alterations (CNAs) in 90 MGUS and 33 MM patients using high‐density DNA microarrays. We identified CNAs in a smaller proportion of MGUS (65.6%) than in MM (100.0%, P = 1.31 × 10?5) and showed median number of CNAs is lower in MGUS (3, range 0–22) than in MM (13, range 4–38, P = 1.82 × 10?10). In the MGUS cohort, the most frequent losses were located at 1p (5.6%), 6q (6.7%), 13q (30.0%), 14q (14.4%), 16q (8.9%), 21q (5.6%), and gains at 1q (23.3%), 2p (6.7%), 6p (13.3%), and Xq (7.8%). Hyperdiploidy was detected in 38.9% of MGUS cases, and the most frequent whole chromosome gains were 3 (25.6%), 5 (23.3%), 9 (37.8%), 15 (23.3%), and 19 (32.2%). We also identified CNAs such as 1p, 6q, 8p, 12p, 13q, 16q losses, 1q gain and hypodiploidy, which are potentially associated with an adverse prognosis in MGUS. In summary, we showed that MGUS is similar to MM in that it is a genetically heterogeneous disorder, but overall cytogenetic instability is lower than in MM, which confirms that genetic abnormalities play important role in monoclonal gammopathies. 相似文献
32.
33.
Pramod Nagaraja Vinod Ravindran Gareth Morris‐Stiff Kesh Baboolal 《Transplant international》2013,26(3):273-280
New‐onset diabetes mellitus (NODAT) is a serious complication following renal transplantation. In this cohort study, we studied 118 nondiabetic renal transplant recipients to examine whether indices of insulin resistance and secretion calculated before transplantation and at 3 months post‐transplantation are associated with the development of NODAT within 1 year. We also analysed the long‐term impact of early diagnosed NODAT. Insulin indices were calculated using homeostasis model assessment (HOMA) and McAuley's Index. NODAT was diagnosed using fasting plasma glucose. Median follow‐up was 11 years. The cumulative incidence of NODAT at 1 year was 37%. By logistic regression, recipient age (per year) was the only significant pretransplant predictor of NODAT (OR 1.04, CI 1.009–1.072), while age (OR 1.04, CI 1.005–1.084) and impaired fasting glucose (OR 2.97, CI 1.009–8.733) were significant predictors at 3 months. Pretransplant and 3‐month insulin resistance and secretion indices did not predict NODAT. All‐cause mortality was significantly higher in recipients developing NODAT within 1 year compared with those remaining nondiabetic (44% vs. 22%, log‐rank P = 0.008). By Cox's regression analysis, age (HR 1.075, CI 1.042–1.110), 1‐year creatinine (HR 1.007, CI 1.004–1.010) and NODAT within 3 months (HR 2.4, CI 1.2–4.9) were independent predictors of death. In conclusion, NODAT developing early after renal transplantation was associated with poor long‐term patient survival. Insulin indices calculated pretransplantation using HOMA and McAuley's Index did not predict NODAT. 相似文献
34.
Deterministic dynamic compartmental transmission models (DDCTMs) of human papillomavirus (HPV) transmission have been used in a number of studies to estimate the potential impact of HPV vaccination programs. In most cases, the models were built under the assumption that an individual who cleared HPV infection develops (life-long) natural immunity against re-infection with the same HPV type (this is known as SIR scenario). This assumption was also made by two Australian modelling studies evaluating the impact of the National HPV Vaccination Program to assist in the health-economic assessment of male vaccination. An alternative view denying natural immunity after clearance (SIS scenario) was only presented in one study, although neither scenario has been supported by strong evidence. Some recent findings, however, provide arguments in favour of SIS. 相似文献
35.
Thomas Machon Gareth P. Alexander 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(35):14174-14179
Knots and knotted fields enrich physical phenomena ranging from DNA and molecular chemistry to the vortices of fluid flows and textures of ordered media. Liquid crystals provide an ideal setting for exploring such topological phenomena through control of their characteristic defects. The use of colloids in generating defects and knotted configurations in liquid crystals has been demonstrated for spherical and toroidal particles and shows promise for the development of novel photonic devices. Extending this existing work, we describe the full topological implications of colloids representing nonorientable surfaces and use it to construct torus knots and links of type (p,2) around multiply twisted Möbius strips. 相似文献
36.
37.
38.
39.
Anne M Williams RN PhD Anne Davies BSc PhD Gareth Griffiths RN BSc 《International journal of nursing practice》2009,15(3):145-155
Nurses often use non-pharmacological measures to facilitate comfort for patients within the hospital setting. However, guidelines for use of these measures are commonly inadequate or absent. This paper presents 12 clinical practice guidelines that were developed from the findings of a literature review into non-pharmacological measures that are thought to facilitate patient comfort. The non-pharmacological measures addressed in these guidelines are: Aromotherapy, Distraction, Guided Imagery, Laughter, Massage, Music, Reiki, Heat or Cold, Meditation, Reflexology, Reposition and Transcutaneous Electrical Nerve Stimulation. These are preliminary guidelines for the use of non-pharmacological measures and further research and development of such guidelines is recommended. 相似文献
40.