全文获取类型
收费全文 | 7041篇 |
免费 | 409篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 88篇 |
儿科学 | 272篇 |
妇产科学 | 157篇 |
基础医学 | 892篇 |
口腔科学 | 61篇 |
临床医学 | 1225篇 |
内科学 | 1320篇 |
皮肤病学 | 70篇 |
神经病学 | 692篇 |
特种医学 | 92篇 |
外科学 | 573篇 |
综合类 | 88篇 |
一般理论 | 6篇 |
预防医学 | 912篇 |
眼科学 | 106篇 |
药学 | 380篇 |
中国医学 | 11篇 |
肿瘤学 | 517篇 |
出版年
2023年 | 23篇 |
2022年 | 39篇 |
2021年 | 79篇 |
2020年 | 77篇 |
2019年 | 105篇 |
2018年 | 126篇 |
2017年 | 115篇 |
2016年 | 107篇 |
2015年 | 135篇 |
2014年 | 199篇 |
2013年 | 325篇 |
2012年 | 456篇 |
2011年 | 478篇 |
2010年 | 293篇 |
2009年 | 254篇 |
2008年 | 467篇 |
2007年 | 505篇 |
2006年 | 517篇 |
2005年 | 517篇 |
2004年 | 464篇 |
2003年 | 527篇 |
2002年 | 496篇 |
2001年 | 60篇 |
2000年 | 62篇 |
1999年 | 71篇 |
1998年 | 104篇 |
1997年 | 81篇 |
1996年 | 70篇 |
1995年 | 56篇 |
1994年 | 55篇 |
1993年 | 57篇 |
1992年 | 34篇 |
1991年 | 42篇 |
1990年 | 29篇 |
1989年 | 33篇 |
1988年 | 35篇 |
1987年 | 31篇 |
1986年 | 20篇 |
1985年 | 26篇 |
1984年 | 33篇 |
1983年 | 33篇 |
1982年 | 26篇 |
1981年 | 31篇 |
1980年 | 26篇 |
1979年 | 15篇 |
1978年 | 18篇 |
1977年 | 15篇 |
1976年 | 21篇 |
1974年 | 8篇 |
1973年 | 12篇 |
排序方式: 共有7462条查询结果,搜索用时 890 毫秒
21.
Mycoplasma pneumoniae Induces Chronic Respiratory Infection, Airway Hyperreactivity, and Pulmonary Inflammation: a Murine Model of Infection-Associated Chronic Reactive Airway Disease 总被引:9,自引:0,他引:9
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Robert D. Hardy Hasan S. Jafri Kurt Olsen Jeanine Hatfield Janie Iglehart Beverly B. Rogers Padma Patel Gail Cassell George H. McCracken Octavio Ramilo 《Infection and immunity》2002,70(2):649-654
Because chronic Mycoplasma pneumoniae respiratory infection is hypothesized to play a role in asthma, the potential of M. pneumoniae to establish chronic respiratory infection with associated pulmonary disease was investigated in a murine model. BALB/c mice were intranasally inoculated once with M. pneumoniae and examined at 109, 150, 245, 368, and 530 days postinoculation. M. pneumoniae was detected in bronchoalveolar lavage fluid by culture or PCR in 70 and 22% of mice at 109 and 530 days postinoculation, respectively. Lung histopathology was normal up to 368 days postinoculation. At 530 days, however, 78% of the mice inoculated with M. pneumoniae demonstrated abnormal histopathology characterized by peribronchial and perivascular mononuclear infiltrates. A mean histopathologic score (HPS) at 530 days of 5.1 was significantly greater (P < 0.01) than that for controls (HPS score of 0). Serum anti-M. pneumoniae immunoglobulin G was detectable in all of the mice inoculated with M. pneumoniae and was inversely correlated with HPS (r = -0.95, P = 0.01) at 530 days postinoculation. Unrestrained whole-body plethysmography measurement of enhanced pause revealed significantly elevated airway methacholine reactivity in M. pneumoniae-inoculated mice compared with that in controls at 245 days (P = 0.03) and increased airway obstruction at 530 days (P = 0.01). Murine M. pneumoniae respiratory infection can lead to chronic pulmonary disease characterized by airway hyperreactivity, airway obstruction, and histologic inflammation. 相似文献
22.
Reductions in depressed mood and denial coping during cognitive behavioral stress management with hiv-positive gay men treated with haart 总被引:1,自引:1,他引:0
Adam W. Carrico M.S. Michael H. Antoni Ph.D. Ron E. Durán Ph.D. Gail Ironson M.D. Ph.D. Frank Penedo Ph.D. Mary Ann Fletcher Ph.D. Nancy Klimas M.D. Neil Schneiderman Ph.D. 《Annals of behavioral medicine》2006,31(2):155-164
Background: Stress management interventions for HIV-positive persons have been designed to enhance coping skills and encourage health-promoting
behaviors with the hope of decreasing distress and slowing disease progression.Purpose: We examined the efficacy of a cognitive behavioral stress management (CBSM) intervention in combination with medication
adherence training (MAT) in 130 gay and bisexual men living with HIV infection.Methods: Participants were randomized to either a 10-week CBSM+MAT intervention (n = 76) or a MAT-only condition (n = 54). Measures
of self-reported adherence, active cognitive coping (i.e., acceptance and positive reinterpretation), avoidant coping (i.e.,
denial and behavioral disengagement), and depressed mood were examined over the 10-week intervention period.Results: Men in CBSM+MAT reported reductions in depressed mood and denial coping during the 10-week intervention period, but no changes
in active cognitive coping or self-reported adherence were observed. Using path analysis, greater reliance on denial coping
at baseline was associated with decreased depressed mood at 10 weeks. We also determined that CBSM+MAT may decrease depressed
mood by reducing reliance on denial coping over the 10-week intervention period.Conclusions: Although denial may be an effective means of distress reduction in the short term, reliance on this coping strategy may
result in a decreased capacity to effectively manage a variety of disease-related stressors in the long term. CBSM+MAT addresses
this potentially detrimental pattern by teaching stress reduction skills that may decrease depressed mood via reduced reliance
on denial coping.
This research was supported by National Institute of Mental Health Grants P01 MH49548 and T32 MH18917. 相似文献
23.
The acquired immunodeficiency syndrome (AIDS) is caused by a retrovirus, the human immunodeficiency virus (HIV). A rapid and convenient method to identify additional cofactors or risk modifiers and markers of disease progression is to study a cohort prevalent with HIV antibody. However, because the time of viral infection is usually unknown in the cohort, there are several potential sources of bias. Three sources of bias in a prevalent cohort study are identified assuming a proportional hazards model: onset confounding, differential length-biased sampling, and frailty selection. A number of problems in the interpretation of results on markers from a prevalent cohort also are considered. It is concluded that risk estimates derived from a prevalent cohort are not directly comparable to risk estimates derived from an incident cohort. 相似文献
24.
Changing economic, political, environmental, and social conditions continue to have a cumulative impact on Australian regional communities, and in many instances, rural communities are being forced to initiate their own strategies in order to remain economically and socially viable. However, while communities respond in differing ways to similar change events, as do individuals, research examining the change process has largely been undertaken at the individual level. This article reports on an investigation of the characteristics that moderate a community's ability to manage change and the types of collective coping strategies communities employ to deal with change events. A model of community change process was used as the framework to examine the links between community characteristics, appraisal of change events (forest restructuring and tourism), and the use of collective strategies in three communities in Western Australia. Findings suggest that a community's mobilization of strategies is dependent on the collective assessment of the change event, the nature of the event, and the characteristics of the community. The implications for intervention through policy and community development are discussed briefly. © 2004 Wiley Periodicals, Inc. J Comm Psychol 32: 201–216, 2004. 相似文献
25.
High intensity focused ultrasound (HIFU) is gaining rapid clinical acceptance as a treatment modality enabling non-invasive tissue heating and ablation for numerous applications. HIFU treatments are usually carried out in a single session, often as a day case procedure, with the patient either fully conscious, lightly sedated or under light general anaesthesia. A major advantage of HIFU over other thermal ablation techniques is that there is no necessity for the transcutaneous insertion of probes into the target tissue. The high powered focused beams employed are generated from sources placed either outside the body (for treatment of tumours of the liver, kidney, breast, uterus, pancreas and bone) or in the rectum (for treatment of the prostate), and are designed to enable rapid heating of a target tissue volume, while leaving tissue in the ultrasound propagation path relatively unaffected. Given the wide-ranging applicability of HIFU, numerous extra-corporeal, transrectal and interstitial devices have been designed to optimise application-specific treatment delivery. Their principle of operation is described here, alongside an overview of the physical mechanisms governing HIFU propagation and HIFU-induced heating. Present methods of characterising HIFU fields and of quantifying HIFU exposure and its associated effects are also addressed. 相似文献
26.
27.
Gail D'Onofrio Edward Bernstein Judith Bernstein Robert H. Woolard Phillip A. Brewer Sandra A. Craig Brian J. Zink 《Academic emergency medicine》1998,5(12):1200-1209
Abstract. Medical and social problems related to alcohol use are frequently seen in the ED. Often, the tempo of emergency medicine practice seems to preclude assessment beyond that required by the acute complaint. However, detection of ED patients with alcohol problems can occur using brief screening tools. This article was developed by members of the SAEM Substance Abuse Task Force, and describes screening tools that have been used successfully to identify atrisk and dependent drinkers. Their brevity, reproducibility, and accuracy vary somewhat, but screening can be realistically performed in the busy ED setting. The early detection of patients with alcohol problems would provide the opportunity for early intervention, and may reduce subsequent morbidity and mortality in this patient population. 相似文献
28.
29.
Howard L Kaufman Seunghee Kim-Schulze Kelledy Manson Gail DeRaffele Josephine Mitcham Kang Seok Seo Dae Won Kim John Marshall 《Journal of translational medicine》2007,5(1):60
Purpose
An open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability and obtain preliminary data on immune response and survival. 相似文献30.
The purposes of this study were to discover the essences of the experience of waiting, to provide new knowledge about what it is like to wait, and to contribute to nursing knowledge. Participants were 12 persons who were family members or friends of persons in an adult critical care unit. The Parse research method was used to answer the research question: What is the structure of the lived experience of waiting? The central finding of this study was this structure: The lived experience of waiting is a vigilant attentiveness surfacing amid an ambiguous turbulent lull as contentment emerges with uplifting engagements. The structure is discussed in relation to nursing knowledge and in relation to how it can inform future research and practice. © 2002 John Wiley & Sons, Res Nurs Health 25:58–67, 2002. 相似文献