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51.
Although renal abnormalities have been described in children with Alagille's syndrome, cystic kidney disease has not often been documented, and then usually only at necropsy. Three children with Alagille's syndrome are described, in two of whom a unilateral multicystic dysplastic kidney was detected by prenatal ultrasound; in the other, a solitary cortical cyst was found later in childhood. All have normal renal function, growth, and liver synthetic function but continue to have clinical and biochemical signs of cholestasis. These cases show that unilateral cystic kidney disease with or without renal dysplasia may be associated with Alagille's syndrome, that the clinical course is not necessarily unfavourable, and that Alagille's syndrome should be included in the differential diagnosis of cystic kidney disorders associated with cholestatic liver disease. Patients with Alagille's syndrome should be evaluated by renal ultrasound. 相似文献
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Pottecher B Herbrecht R Blanc-Vincent MP Bussy Malgrange V Escande MC Fuhrmann C Crokaert F Gory-Delabaere G Senet JM Lesimple T Raveneau J Béal J Biron P Viot M 《Bulletin du cancer》2000,87(7-8):557-591
CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of the French Cancer Centres (FNCLCC), the 20 French Cancer Centres and specialists from French Public Universities, General Hospitals and Private Clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and outcome for cancer patients. The methodology is based on literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. OBJECTIVES: To develop clinical practice guidelines according to the definitions of the Standards, Options and Recommendations project for the prevention and the surveillance of cross infection in oncology. METHODS: Data were identified by searching Medline and the personal reference lists of members of the expert groups. Once the guidelines were defined, the document was submitted for review to 106 independent reviewers, and to the medical committees of the 20 French Cancer Centres. RESULTS: 1) Criteria of infection status and nosocomiality defined by the Centers for Infectious Diseases (CDC) and Prevention and the Superior Council of Public Hygiene (CSHPF) are not adapted and have to be redefined in oncology. 2) The epidemiology of nosocomial infections in oncology is not well known but their incidence seems to be higher. Numerous risk factors of cross infections coexist in cancer patients, among which the duration and depth of neutropenia. 3) Surveillance and prevention of cross infection are compulsory and were taken into account in the accreditation of hospitals. Obligation is expressed in terms of means and results. 4) The objectives of the cross infection surveillance are to detect major problems and critic situations, to guide probabilistic antibiotic therapy and to assess the effectiveness of the infections control. The surveillance means consist in prevalence and incidence survey, punctually and continuously conducted. 5) The three specific behaviors to be adopted to prevent cross infections are to control: all the patients, infected patients carrying multiresistant bacteria, immunodepressed patients. 6) Standards of care have to be applied to a/l patients with cancer. 7) It is necessary to add particular septic cares for the patients infected with micro-organisms indicated on reference lists or carrying multiresistant bacteria. 8) The only objective of the protective isolation of immunodepressed cancer patients is to reduce the cross infection. There is no standard behavior for the indications and the modalities of protective isolation. The prevention behaviors to be taken are defined by expert agreements. 相似文献
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Metatarsalgia is explained as localized or more diffuse tenderness beneath the metatarsal heads. The pain may be attributed to various etiologies. Pathological changes affecting the positional relationship of the metatarsals in the sagittal plane can cause increased pressure and friction forces during weight bearing. Since the length of the metatarsals displays a wide range of disparity only a few pathological settings, i.e., brachymetatarsia, require surgical correction. Beside those disorders of positional relationship, metatarsalgia may be due to lesser toe deformities, osteonecrosis of a lesser metatarsal head (Koehler's disease), and neurological disorders (Morton's neuroma).Apart from the etiology increased load, which is transferred to the central metatarsals, can be treated successfully with orthotic devices. If conservative measures fail, surgical treatment can be indicated. Prior to any operative therapy it is mandatory to perform a detailed analysis of the underlying pathology to avoid persistent pain or recurrence of the deformity. 相似文献
60.
G. Ruhenstroth-Bauer G. F. Fuhrmann Elke Bey und E. Hertel 《Journal of molecular medicine (Berlin, Germany)》1966,44(1):39-41
Zusammenfassung 1. Bei der täglichen Fütterung von jungen Ratten mit etwa 600 µg Diäthylnitrosamin treten nach etwa 120–140 Tagen die ersten mikroskopisch und makroskopisch nachweisbaren stecknadelkopfgroßen Tumoren auf. Vorher sind im gesamten Leberparenchym degenerative Veränderungen nachweisbar.2. Zellelektrophoretisch findet man etwa vom 100. Tag nach Fütterungsbeginn an beiallen Leberzellen eine Erhöhung der negativen Überschußladung der Membran. Dieser Anstieg geht dem Auftreten der histologisch nachweisbaren Tumoren um 2–4 Wochen voraus und erfolgt allmählich; die Kurve bleibt dann auf dem erreichten Niveau stehen.
Summary 1. The daily feeding of young rats with about 600 µg diethylnitrosamine effects the appearance of microscopically and macroscopically visible tumors after 120 to 140 days. Prior to that time there appears to be only degenerative changes.2. By cell-electrophoresis one observes an increase of the negative membrane charge inall the liver cells from about the 100th day after the commencement of feeding. This increase begins 2–4 weeks earlier than the appearance of the tumors and takes place gradually.相似文献