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271.
272.
Duplications of the entire colon are very rare. An 18-month-old boy presented with symptoms of chronic constipation and was noted with a complete colonic duplication. The presentation and management are discussed. 相似文献
273.
274.
Hanspeter Huber Guillaume André Francine Rumeau Pierre Journeau Thierry Haumont Pierre Lascombes 《Journal of children's orthopaedics》2012,6(2):119-123
Purpose
Distal femoral fractures are quite common in nonambulating patients with myopathies, as they present marked osteoporosis. The deterioration of preexisting knee flexion contracture is a known problem, as these fractures are usually angulated posteriorly. The goals of treatment are to reduce immobilization and bed rest to a minimum, prevent function loss, and prevent refracture. The aim of our work was to investigate if these goals can be achieved by an operative treatment with closed reduction and flexible intramedullary nailing (FIN). 相似文献275.
276.
Absence of Lamellar Bodies with Accumulation of Dense Bodies Characterizes a Novel Form of Congenital Surfactant Defect 总被引:1,自引:0,他引:1
A. Francine Tryka Susan E. Wert Jon E. Mazursky Robert W. Arrington Lawrence M. Nogee 《Pediatric and developmental pathology》2000,3(4):335-345
Two female sibling full-term newborns developed respiratory distress shortly after birth, which progressed to respiratory
failure. Tracheal lavage demonstrated presence of surfactant protein A (SP-A), but little surfactant protein B (SP-B), without
aberrant surfactant protein C (SP-C). On a lung biopsy performed in both infants, prominent type II pneumocyte hyperplasia
was evident. Through ultrastructural examination an absence of normally formed lamellar bodies was determined, with numerous
irregular electron dense bodies within the type II pneumocytes. These electron dense bodies could also be identified in the
alveolar spaces and alveolar macrophages. No alveolar tubular myelin was present. Abnormally high immunoreactivity for surfactant
proteins SP-A, proSP-B, SP-B, and proSP-C was demonstrated by light microscopy. Presence of incompletely processed immunopositive
proSP-B, but not proSP-C was observed in the alveolar lumina. No mutations in either the SP-B or SP-C gene were identified
by sequence analysis of amplified cDNA. We conclude that these siblings exhibit an inherited surfactant deficiency characterized
by abnormal accumulations of surfactant proteins within the pneumocytes. This abnormal accumulation may be due to a primary
secretory defect, a defect in surfactant phospholipids, or an abnormal interaction between the phospholipids and surfactant
proteins.
Received November 17, 1998; accepted August 19, 1999. 相似文献
277.
278.
Leishmania infantum: Lack of Parasite Resistance to Amphotericin B in a Clinically Resistant Visceral Leishmaniasis
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Remy Durand Muriel Paul Francine Pratlong Daniele Rivollet Marie-Laure Dubreuil-Lemaire Rene Houin Alain Astier Michele Deniau 《Antimicrobial agents and chemotherapy》1998,42(8):2141-2143
Amphotericin B (AmB) has been used as a second-line treatment of visceral leishmaniasis, particularly in human immunodeficiency virus-positive patients. AmB median effective doses (ED50s) were determined on an isolate obtained before any treatment and on a second isolate obtained 4 years later from the same AmB-treated patient. ED50s were similar (0.059 and 0.067 mg/kg of body weight, respectively), demonstrating the first evidence of AmB ED50 stability of Leishmania infantum after a long-term drug exposure. An isoenzymatic study was performed in order to verify that the second isolate originated from the same parasite as the first isolate. The present case report showed that treatment failure was not due to parasite resistance in spite of a prolonged exposure to the drug. 相似文献
279.
Maria Teresa Hernandez Hannelore C Sauerwein Isabelle Jambaqué Elaine De Guise Francine Lussier Anne Lortie Olivier Dulac Maryse Lassonde 《Neuropsychologia》2002,40(4):384-400
Frontal lobe dysfunction in adults has been associated with impairments of planning abilities, working memory, impulse control, attention and certain aspects of motor coordination. However, very few studies have attempted to assess these functions in children suffering from frontal lobe epilepsy. The aim of the present study was to determine whether some or all of the components of the frontal lobe syndrome are present in children with this disorder. For this purpose, a neuropsychological test battery was administered to 32 unresected epileptic children, aged 8-16 years: 16 with frontal lobe epilepsy (FLE), eight with temporal lobe epilepsy (TLE) and eight with generalized epilepsy whose principal manifestations were typical absences (GEA). The performances of the three epileptic groups were further compared to normative data derived from 200 French-speaking, healthy children aged 7-16 years, except for standardized tests for which the norms provided in the manual were used. The three epilepsy groups did not differ with respect to conceptual shift and recency memory. However, the FLE children showed deficits in planning and impulse control. Furthermore, they had significantly more coordination problems and exhibited greater rigidity than the other epilepsy groups on the motor tests. These problems were more marked in younger FLE children (8-12 years). The latter were also more impaired on verbal fluency measures. No differences were observed with respect to gender, localization of the epileptic abnormality (unilateral versus bilateral) or medication (monotherapy versus polytherapy). The findings reveal similarities between the neuropsychological profiles of FLE children and adults with frontal lobe lesions. 相似文献
280.
Chantal Proulx Pierre Chartrand Valérie Roy Mindy Goldman Francine Décary Aline Rinfret 《Vox sanguinis》1997,72(1):52-60
Background and objectives: Certain clinical conditions are related to the presence of platelet-specific alloantibodies in the patient's serum. We studied the molecular diversity of HPA-1a antibodies to analyze some peculiarities of this antibody response. Materials and methods: Human antibody Fab fragments that bind to the platelet alloantigen HPA-1a on glycoprotein IIb–IIIa (GPIIbIIIa) were generated by using a recombinant phage display system. We established an immunoglobulin G1, kappa combinatorial library from the peripheral blood lymphocytes of a person undergoing a severe posttransfusion purpura. Results: Characterization of Fab clones selected from the fifth round of antigen-specific panning of this library demonstrates a highly specific reactivity to the HPA-1a alloantigen. The nucleotide sequence analysis of representative HPA-1a-specific clones reveals at least 3 distinct VL and 3VH gene segments that present an extensive degree of mutation as demonstrated by comparison of gene usage and homologies to the nearest germline genes. Conclusions: These human HPA-1a-specific Fab reagents should allow us to better understand the molecular mechanism involved in HPA-1a alloimmunization. 相似文献