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991.
992.
Federica Cipriani Mohammad Alzoubi David Fuks Francesca Ratti Takayuki Kawai Giammauro Berardi Leonid Barkhatov Panagiotis Lainas Marcel Van der Poel Morad Faoury Marc G. Besselink Mathieu DHondt Ibrahim Dagher Bjorn Edwin Roberto Ivan Troisi Olivier Scatton Brice Gayet Luca Aldrighetti Mohammad Abu Hilal 《Journal of hepato-biliary-pancreatic sciences》2020,27(1):3-15
993.
994.
Yoshito Tomimaru Nariaki Fukuchi Shigekazu Yokoyama Takuji Mori Masahiro Tanemura Kenji Sakai Yutaka Takeda Masanori Tsujie Terumasa Yamada Atsushi Miyamoto Yasuji Hashimoto Hisanori Hatano Junzo Shimizu Keishi Sugimoto Masaki Kashiwazaki Shogo Kobayashi Yuichiro Doki Hidetoshi Eguchi 《Journal of hepato-biliary-pancreatic sciences》2020,27(8):451-460
995.
Marco Fiore Sveva Di Franco Aniello Alfieri Maria Beatrice Passavanti Maria Caterina Pace Stephen Petrou Francesca Martora Sebastiano Leone 《World journal of hepatology》2020,12(12):1136-1147
Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gram-negative bacteria. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as organisms causing spontaneous bacterial peritonitis. Infections caused by CRE have shown a higher mortality rate than those caused by bacteria sensitive to carbapenem antibiotics. Current antibiotic guidelines for the treatment of spontaneous bacterial peritonitis are insufficient, and rapid de-escalation of empiric antibiotic treatment is not widely recognized. This review summarizes the molecular characteristics, epidemiology and possible treatment of spontaneous bacterial peritonitis caused by CRE. 相似文献
996.
Mutsumi Araki Misaho Kitayoshi Yan Dong Miku Hirane Shuhei Ozaki Shiori Mori 《Growth factors (Chur, Switzerland)》2014,32(3-4):117-122
AbstractLysophosphatidic acid (LPA) is a bioactive lipid that interacts with G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). Here, we investigated the effects of LPA signaling via LPA5 on cellular functions of sarcoma cells by generating Lpar5 overexpressing and Lpar5 knockdown cells from rat osteosarcoma and malignant fibrous histiocytoma cells, respectively. The cell motility activity of Lpar5 overexpressing cells was significantly lower, while Lpar5 knockdown cells showed high cell motility, compared with respective controls. Gelatin zymography showed that LPA5 suppressed the activation of matrix metalloproteinase-2. LPA5 also inhibited the cell motility activity of endothelial cells, correlating with the expression levels of vascular endothelial growth factor genes. These results suggest that LPA signaling via LPA5 negatively regulates the cellular functions of rat sarcoma cells. 相似文献
997.
Andreas Lazaros Chryssafidis Germán Cantón Francesca Chianini Elisabeth A. Innes Ed Hoffmann Madureira Solange Maria Gennari 《Parasitology research》2014,113(4):1521-1528
Neospora caninum is a protozoan parasite known as an important cause of bovine abortion worldwide. Little is currently known about how different strains of N. caninum vary in their pathogenicity. In this study, we compared a Brazilian strain, Nc-Bahia, with the first isolate of this coccidian, Nc-1. Eight cows and seven buffaloes were submitted to fixed-time artificial insemination protocols for a better control of pregnancy. Group 1 was inoculated with Nc-Bahia (n?=?8; five cows and three buffaloes), and Group 2 was inoculated with Nc-1 (n?=?5; two cows and three buffaloes). One nonpregnant female of each species was left uninfected as sentinel controls for potential environmental infection. All inoculated animals received 5?×?108 tachyzoites of N. caninum, by intravenous route, on the 70th day of gestation. Uninfected animals remained seronegative throughout the experiment, indicating no exogenous infection, whereas all inoculated animals became seropositive to N. caninum. In Group 1, abortion was found in only one cow on 42 days postinfection (dpi; frequency of abortion?=?12.5 %), whilst all animals from Group 2 aborted on 35 dpi (frequency of abortion?=?100 %). Parasite DNA was detected by seminested PCR in maternal, foetal and placental tissues, confirming vertical transmission in Groups 1 and 2, although histological lesions had different frequencies and degrees of severity between the groups. There was evidence of lower pathogenicity of Nc-Bahia compared to Nc-1 when used in experimental infection, as it caused fewer abortions, as well as less frequent and milder histological lesions. This was the first time Nc-Bahia has been used for experimental infection. 相似文献
998.
Lnk prevents inflammatory CD8+ T‐cell proliferation and contributes to intestinal homeostasis 下载免费PDF全文
Hiroko Katayama Taizo Mori Yoichi Seki Masaki Anraku Masanori Iseki Masashi Ikutani Yukiko Iwasaki Nobuaki Yoshida Kiyoshi Takatsu Satoshi Takaki 《European journal of immunology》2014,44(6):1622-1632
The intracellular adaptor Lnk (also known as SH2B3) regulates cytokine signals that control lymphohematopoiesis, and Lnk?/? mice have expanded B‐cell, megakaryocyte, and hematopoietic stem‐cell populations. Moreover, mutations in the LNK gene are found in patients with myeloproliferative disease, whereas LNK polymorphisms have recently been associated with inflammatory and autoimmune diseases, including celiac disease. Here, we describe a previously unrecognized function of Lnk in the control of inflammatory CD8+ T‐cell proliferation and in intestinal homeostasis. Mature T cells from newly generated Lnk–Venus reporter mice had low but substantial expression of Lnk, whereas Lnk expression was downregulated during homeostatic T‐cell proliferation under lymphopenic conditions. The numbers of CD44hiIFN‐γ+CD8+ effector or memory T cells were found to be increased in Lnk?/? mice, which also exhibited shortening of villi in the small intestine. Lnk?/? CD8+ T cells survived longer in response to stimulation with IL‐15 and proliferated even in nonlymphopenic hosts. Transfer of Lnk?/? CD8+ T cells together with WT CD4+ T cells into Rag2‐deficient mice recapitulated a sign of villous abnormality. Our results reveal a link between Lnk and immune cell‐mediated intestinal tissue destruction. 相似文献
999.
1000.
Keiji Suzuki Noriyuki Sakata Katsuya Hiraishi Ichiro Mori Masamitsu Takatama 《ACTA HISTOCHEMICA ET CYTOCHEMICA》2014,47(5):211-217
Hypertensive rat arteries exhibited severe medial smooth muscle cell injury and necrosis. Electron microscopic observations showed the smooth muscle cells of these arteries exhibited characteristics of focal cytoplasmic necrosis forming new cytodemarcating membrane between the healthy cytoplasm and necrotic cytoplasm. When the focal necrotic cytoplasm disappeared from the injured smooth muscle cells, it left it with a moth-eaten leaf-like appearance (moth-eaten necrosis). At an advanced stage of injury, smooth muscle cells changed to islet-like cell bodies with newly formed basement membranes around them, and further islet-like cell bodies and cell debris disappeared leaving lamellar and reticular basement membranes.In hypertensive rats injected with nitroblue tetrazolium (NBT), formazan deposits were observed in the medial cells and nitrotyrosine, a biomarker of peroxynitrite, were immunohistochemically observed in the arterial media. Nick-end positive extranuclear small granular bodies, which might have derived from focal necrotic cytoplasm and nucleus, were detected in the arterial media using DNA nick-end labeling method. Based on electron microscopical and histochemical findings, we conjectured that the focal cytoplasmic necrosis of the smooth muscle cells in the arterial media depended on injury arising from mitochondria-derived oxidants. 相似文献