全文获取类型
收费全文 | 993篇 |
免费 | 49篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 43篇 |
妇产科学 | 5篇 |
基础医学 | 80篇 |
口腔科学 | 6篇 |
临床医学 | 77篇 |
内科学 | 242篇 |
皮肤病学 | 32篇 |
神经病学 | 56篇 |
特种医学 | 53篇 |
外国民族医学 | 10篇 |
外科学 | 194篇 |
综合类 | 6篇 |
预防医学 | 129篇 |
眼科学 | 2篇 |
药学 | 29篇 |
肿瘤学 | 73篇 |
出版年
2023年 | 7篇 |
2022年 | 14篇 |
2021年 | 33篇 |
2020年 | 16篇 |
2019年 | 33篇 |
2018年 | 46篇 |
2017年 | 21篇 |
2016年 | 31篇 |
2015年 | 23篇 |
2014年 | 31篇 |
2013年 | 60篇 |
2012年 | 74篇 |
2011年 | 85篇 |
2010年 | 44篇 |
2009年 | 47篇 |
2008年 | 64篇 |
2007年 | 56篇 |
2006年 | 66篇 |
2005年 | 49篇 |
2004年 | 36篇 |
2003年 | 32篇 |
2002年 | 41篇 |
2001年 | 13篇 |
2000年 | 5篇 |
1999年 | 13篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 8篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1983年 | 5篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 4篇 |
1969年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有1043条查询结果,搜索用时 15 毫秒
31.
Maria Villar Loreto Santa-Marina Mario Murcia Pilar Amiano Silvia Gimeno Ferran Ballester Jordi Julvez Dora Romaguera Ana Fernández-Somoano Adonina Tardón Jesús Ibarluzea 《Maternal and child health journal》2018,22(5):725-734
Objective The aim of the study was to identify factors associated with non-initiation and cessation of predominant breastfeeding (PBF) in a mother–child cohort from Spain. Materials and Methods The analysis included 2195 mother-infant from birth to 14 months post- delivery recruited between 2004 and 2008. Maternal characteristics were collected during the pregnancy. Lactation data were obtained at 6 and 14 months after delivery. PBF was defined as intake of breast milk plus liquids like juices or water. The PBF cessation was calculated using the date that women started PBF and the date that she reported to start giving infant formula and/or food. The relationship between maternal variables and PBF initiation and cessation was modeled using logistic and Cox proportional hazards regression analysis. Results The prevalence of PBF at hospital discharge was 85.3, 53.4% at 3 months, 46.1% at 4 months and 7.2% at 6 month. Only two women continued PBF at 12 months and none at 14 months. The initiating of PBF was associated with higher levels of maternal education, being a first-time mother and worked in a non-manual occupation. Higher level of physical activity, not smoking and having a healthy BMI, were also positively associated with PBF initiation. PBF cessation was higher in young, obese women, who had had complications during the pregnancy, and who had lower levels of education and smoked. The employment status of women, in week 32 of pregnancy and also in month 14 post-delivery, determined likelihood of PBF cessation. Conclusions Healthier habits and education positively influenced PBF initiation and duration. Decrease in PBF duration rates in Spain can be interpreted in part as a consequence of women returning to work. 相似文献
32.
33.
Marc Argente Elisenda Miró Carmina Martí Ana Vilamala Carles Alonso-Tarrés Frederic Ballester Ana Calderón Carmen Gallés Asunción Gasós Beatriz Mirelis Montserrat Morta Montserrat Olsina Goretti Sauca Montserrat Sierra Alba Rivera Ferran Navarro 《Enfermedades infecciosas y microbiología clínica》2019,37(2):82-88
34.
Elia Díez Ferran Daban Maribel Pasarín Lucía Artazcoz Carmen Fuertes M. José López Núria Calzada 《Gaceta sanitaria / S.E.S.P.A.S》2014
Objective
Social isolation impairs health. An intervention to reduce isolation due to architectural barriers in elderly persons was carried out in Barcelona (Spain). This study aimed to evaluate its effects on health.Methods
We conducted a quasi-experimental before-after study. Isolated older people were identified in three deprived urban areas from 2009 to 2011. Participants had twice-weekly outings with volunteers in a stair-climbing power wheelchair. User satisfaction was evaluated and perceived health status, quality of life, and mental health before and after four outings were compared with McNemar tests.Results
There were 74 participants (median age: 83 years; IQR: 78-89). Perceived health improved by 21%, mental health by 24%, and psychological distress was reduced by 16%. Most participants (98%) were satisfied.Conclusion
The intervention improved perceived health and mental health. Elderly people with impaired mobility should not live in buildings with architectural barriers and, if this cannot be avoided, similar programs should be implemented. 相似文献35.
Beatriz G. Armendáriz Maria del Mar Masdeu Eduardo Soriano Jesús M. Ureña Ferran Burgaya 《The European journal of neuroscience》2014,40(11):3573-3590
Although it was originally characterized as a constituent of focal adhesions in fibroblasts, focal adhesion kinase (FAK) is now considered to be not only a mediator of adhesion processes but also a crucial regulator of guidance and a modulator of gene expression. FAK is the main transducer of the integrin signaling required to stabilize the actin cytoskeleton. However, additional activities have been described over the years. In the brain, FAK deserves particular attention as it is found in various alternatively spliced forms – these distributed in multiple subcellular compartments or bound to multiple partners. Moreover, its signaling involves not only phosphorylation but also ubiquitination and proteolysis. Several experimental cell models demonstrate that FAK increases or decreases migration, participates in differentiation and contributes to plasticity events. In addition, this kinase is linked to cell survival in cancer and apoptosis. This review focuses on the diversity of events involving brain‐located forms of FAK. 相似文献
36.
Ferran Poveda Debora Gil Enric Martí Albert Andaluz Manel Ballester Francesc Carreras 《Revista espa?ola de cardiología》2013,66(10):782-790
Introduction and objectives
Deeper understanding of the myocardial structure linking the morphology and function of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Several conceptual models of myocardial fiber organization have been proposed but the lack of an automatic and objective methodology prevented an agreement. We sought to deepen this knowledge through advanced computer graphical representations of the myocardial fiber architecture by diffusion tensor magnetic resonance imaging.Methods
We performed automatic tractography reconstruction of unsegmented diffusion tensor magnetic resonance imaging datasets of canine heart from the public database of the Johns Hopkins University. Full-scale tractographies have been built with 200 seeds and are composed by streamlines computed on the vector field of primary eigenvectors at the diffusion tensor volumes. We also introduced a novel multiscale visualization technique in order to obtain a simplified tractography. This methodology retains the main geometric features of the fiber tracts, making it easier to decipher the main properties of the architectural organization of the heart.Results
Output analysis of our tractographic representations showed exact correlation with low-level details of myocardial architecture, but also with the more abstract conceptualization of a continuous helical ventricular myocardial fiber array.Conclusions
Objective analysis of myocardial architecture by an automated method, including the entire myocardium and using several 3-dimensional levels of complexity, reveals a continuous helical myocardial fiber arrangement of both right and left ventricles, supporting the anatomical model of the helical ventricular myocardial band described by F. Torrent-Guasp. 相似文献37.
Esther Sapiña-Beltrán Gerard Torres Montserrat Martínez-Alonso Manuel Sánchez-de-la-Torre Maria Franch Carmen Bravo Juan F. Masa Miquel Felez Ana Maria Fortuna-Gutierrez Jorge Abad Francisco García-Río Luciano F. Drager Ronald Lee Chi-Hang Miguel Ángel Martínez-García Ferran Barbé Mireia Dalmases 《Archivos de bronconeumologia》2018,54(10):518-523
Introduction
Patients with resistant hypertension (RH) have a high risk of developing cardiovascular events; therefore, new therapeutic approaches to better control blood pressure may be useful in improving cardiovascular outcomes. The prevalence of obstructive sleep apnea (OSA) is very high among patients with RH. Continuous positive airway pressure (CPAP) has been shown to be an effective treatment for reducing blood pressure in patients with RH. Nevertheless, the long-term effect of CPAP treatment on cardiovascular outcomes has not been explored.The main objective of the SARAH study is to assess the impact of OSA and its treatment on cardiovascular outcomes (morbidity and mortality) in patients with RH.Methods
This study is a multi-center, prospective, observational cohort study. A total of 1371 patients with RH will be enrolled in the study and followed once a year for five years. At inclusion, ambulatory blood pressure monitoring (ABPM) and a sleep study will be performed in all subjects. Socio-demographic, clinical and cardiovascular variables will be collected at baseline and follow-up. Subsequently, subjects with OSA will be managed according to local standard practice. Based on the OSA diagnosis and its treatment, three cohorts of subjects with RH will be defined: non-OSA, treated OSA and non-treated OSA.Conclusions
This study will contribute to elucidating the long-term impact of OSA treatments on blood pressure control and cardiovascular outcomes in patients with RH. These results will contribute to improve the cardiovascular prognosis of patients with RH. 相似文献38.
39.
Ferran Pons David J. Lewkowicz Salvador Soto-Faraco Núria Sebastián-Gallés 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(26):10598-10602
The conventional view is that perceptual/cognitive development is an incremental process of acquisition. Several striking findings have revealed, however, that the sensitivity to non-native languages, faces, vocalizations, and music that is present early in life declines as infants acquire experience with native perceptual inputs. In the language domain, the decline in sensitivity is reflected in a process of perceptual narrowing that is thought to play a critical role during the acquisition of a native-language phonological system. Here, we provide evidence that such a decline also occurs in infant response to multisensory speech. We found that infant intersensory response to a non-native phonetic contrast narrows between 6 and 11 months of age, suggesting that the perceptual system becomes increasingly more tuned to key native-language audiovisual correspondences. Our findings lend support to the notion that perceptual narrowing is a domain-general as well as a pan-sensory developmental process. 相似文献
40.