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Giovanna Russo-Mancuso Felicia Di Gregorio Enrica Passero Antonella Sciotto Maria Clorinda Mazzarino† Grazia Malaponte† Gino Schilirog 《British journal of haematology》1995,89(2):291-298
Summary. α-interferon (α-IFN) has been used to treat chronic non-A non-B hepatitis in thalassaemic patients with response rates from 45% to 83%. Unfortunately, treatment with α-IFN is associated with side-effects which have a negative effect on the quality of life of the patient. Therefore it would be useful if we could distinguish in advance those patients who would benefit from such therapy from those who would not. In the present study we found that the modification of lymphocyte subsets 20 h after the administration of the first dose of α-IFN revealed that relative numbers of T helper lymphocytes (CD4+ ) increased in three non-responding patients and decreased in five responding patients, whereas those of T suppressor lymphocytes (CD8+ ), and natural killer cells (CD57+ . CD16+ ) decreased in non-responding patients and increased in responding patients. Therefore analysis of the lymphocyte subsets CD4, CD8, CD57 and CD16 before and 20 h after the administration of α-IFN can be used to predict the clinical response to treatment with α-IFN. 相似文献
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Yu-Ling Chang Maura Rossetti David W. Gjertson Liudmilla Rubbi Michael Thompson Dennis J. Montoya Marco Morselli Felicia Ruffin Alexander Hoffmann Matteo Pellegrini Vance G. Fowler Jr Michael R. Yeaman Elaine F. Reed with the MRSA Systems Immunology Group 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(10)
106.
Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance. 总被引:7,自引:1,他引:7
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Antigenic proteins may be absorbed intact. We report here results from in vivo experiments in mice showing that the prior feeding of protein antigen may reduce the subsequent absorption of that antigen without altering its elimination from the circulation. This may be a function of local immunity. We have also shown that the same feeding regime can paradoxically induce a state of systemic tolerance and suggest that the two phenomena contribute to the safe handling of these antigens. 相似文献
107.
The effects of comprehensive home physiotherapy and supervision on patients with ankylosing spondylitis--a randomized controlled trial 总被引:2,自引:0,他引:2
Fifty-three patients with ankylosing spondylitis (AS) were randomly allocated; 26 experimental patients received physiotherapy and disease education, 27 control patients received neither. The primary treatment outcome was change in spinal mobility measured at 4 months by fingertip-to-floor distance. Experimental patients had more improvement in fingertip-to-floor distance (p2 less than 0.004) and in function (p2 less than 0.001) than control patients. Physiotherapy with disease education is effective in the treatment of patients with AS. 相似文献
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Alexis M. Jackson Adrian Munguía-Vega Avian S. Lain Simon A. Stokes Aneese J. Williams Giacomo Bernardi 《Conservation Genetics Resources》2014,6(1):185-187
Leopard grouper (Mycteroperca rosacea) are distributed from Bahía Magdalena, through the Gulf of California and as far south as Jalisco, Mexico. They are listed as Vulnerable on the IUCN Red List due to significant fishing-induced declines over the past decade. Microsatellite loci were isolated by constructing a shotgun genomic library and sequencing using 454 XL + titanium chemistry. We characterized 15 polymorphic loci in 120 samples from three geographic locations. Genotyping yielded 15–60 alleles per locus with observed levels of heterozygosity ranging from 0.575 to 0.975. 相似文献
110.
Vito Leonardo Miniello Maria Felicia Faienza Pietro Scicchitano Francesca Cortese Michele Gesualdo Annapaola Zito Marina Basile Pasquale Recchia Domenico Leogrande Domenico Viola Paola Giordano Marco Matteo Ciccone 《International journal of cardiology》2014