Dqβ polymorphism and genetic susceptibility to felty's syndrome

We used an oligonucleotide probe specific for a polymorphic sequence in the HLA-DQβ gene to investigate the role of DQ polymorphism in genetic susceptibility to Felty's syndrome (FS) and rheumatoid arthritis (RA). The sequence of this gene was identified from a complementary DNA library derived from an RA patient's B lymphoblastoid cell line. With this probe, we studied the prevalence of the specific DQβ allele in DR4 positive FS patients, RA patients, and normal control subjects. Significantly more FS patients (17 of 25) showed hybridization with this oligonucleotide probe, compared with the number of DR4 positive non-FS RA patients (7 of 23) and normal controls (7 of 21). The findings indicate that genes linked to the DQ region are important in determining susceptibility to FS.     

帕罗西汀对皮质酮抑制成年大鼠海马细胞增殖的调制作用(英文)

目的慢性糖皮质激素治疗可能导致认知和情感变化,这或许是由于糖皮质激素对海马神经发生及细胞增殖的抑制作用造成。帕罗西汀是一种选择性血清素重摄取抑制剂,临床常用作减轻抑郁症状,近几年来发现它能促进海马神经发生。本研究探讨帕罗西汀与慢性糖皮质激素的相互作用。方法成年大鼠被分成四组,分别给予芝麻油、皮质酮、帕罗西汀或皮质酮和帕罗西汀十四天。溴脱氧尿嘧啶核苷(5-bromo-2-deoxyuridine,BrdU)免疫组化法被用于定量齿状回的细胞增殖。结果皮质酮抑制了海马的细胞增殖,帕罗西汀增加了海马的细胞增殖。同时给药组还显示帕罗西汀能逆转皮质酮的抑制作用。结论本研究结果对防止海马在类固醇治疗以后的损害或许有临床意义。     

Establishing high‐quality reference values for nerve conduction studies: A report from the normative data task force of the American Association Of Neuromuscular & Electrodiagnostic Medicine

Introduction: There are not uniform standards for nerve conduction testing across the United States. The objective of this study is to present a set of methodologically sound criteria to evaluate the literature for the purpose of identifying high‐quality normative nerve conduction studies (NCS) suitable for widespread use. Methods: The Normative Data Task Force (NDTF) was formed to review published studies on methodological issues related to NCS. A set of criteria was then developed to evaluate the literature. These criteria and their rationale are described. Results: We identified 7 key issues that reflect high quality in NCS. For each issue, specific review criteria were developed. Conclusion: Rigorous criteria enable identification of high‐quality studies dealing with nerve conduction reference values. This represents the first step toward the overarching goal of recommending NCS techniques and reference values for electrodiagnostic medicine. Muscle Nerve 54 : 366–370, 2016     

乳腺癌患者癌因性疲乏与抑郁、焦虑情绪的调查

目的 探讨乳腺癌患者中癌因性疲乏与抑郁、焦虑情绪的发生情况及两者相关性。方法 分别采用Piper疲乏评估量表和HAD情绪测定量表,评价200例乳腺癌术后患者的癌因性疲乏与抑郁、焦虑情绪的状况,收集数据并分析。结果 在200例乳腺癌术后患者中,109例（54.5％）乳腺癌患者经历了不同程度的癌因性疲乏,整体疲乏评分为4.38±1.27。行为／严重性维度、情感维度、感觉维度、认知／情绪维度评分分别为3.73±1.67、5.06±1.84、 4.39±1.60和4.38±1.35。在各维度中,评分最高的条目分别为“疲乏对性生活的影响”、 “疲乏令自己不愉快的程度”、“感到身体虚弱”和“感到无记性的程度”。109例癌因性疲乏的患者中合并焦虑情绪者34例（31.2%）,合并抑郁情绪者45例（41.3%）,癌因性疲乏同时合并抑郁、焦虑者27例（24.8%）。存在癌因性疲乏的患者中焦虑、抑郁发病比例明显高于无癌因性疲乏患者（P＜0.001）,存在焦虑、抑郁的患者与不存在焦虑或抑郁情绪的患者在癌因性疲乏各维度评分有显著差异（P＜0.05）。结论 乳腺癌术后患者癌因性疲乏的发生率较高,疲乏水平属轻、中度,焦虑、抑郁情绪与其密切相关,癌因性疲乏的病因、治疗方法有待进一步研究。     

Immunological response to Helicobacter pylori among healthy volunteers in Agbor,Nigeria

ObjectiveTo determine Helicobacter pylori (H. pylori) immunologically.MethodThe seroprevalence of H. pylori infection was determined by ELISA technique in 380 individuals who gave informed consent, comprising 180 males (47.4%) and 200 females (52.6%) in Agbor, Nigeria. 124 (27.4%) of the subjects lived in the rural communities while 276 (72.6%) lived in the urban areas of Agbor. They were aged 1 to over 70 yr [(mean age±SD)=(39±9. 42) yr]. Five milliliter of clotted blood was obtained from each subject for specific HP-IgG antibodies.ResultsAntibodies to H. pylori were detected in serum of 159 males (88.3%) and 182 females (91.0%). This was not statistically significant (P> 0.05). A total of 341 (89.7±21.4%) subjects presented anti-H. pylori antibodies. The prevalence of H. pylori increased with age from 14.8% in age group 1–9 yr to 100% in age group 30-39 yr and 60–69 yr. At above 70 yr, the seroprevalence decreased to 93.3%.ConclusionsThe prevalence of H. pylori in Agbor is very high among adults while comparatively low among children. Since a lot of factors have been attributed to affect the rate of infection, increased standard of living and improved public health measures are encouraged and studies on the development and administration of an effective vaccine is recommended.