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101.
The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P<0.05) decreased skin papilloma development during promotion phase. SD significantly (P<0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P<0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation. 相似文献
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103.
Coccidioidomycosis has been reported in almost every tissue of the human body. The gastrointestinal tract and breast have been uniquely spared from this fungal infection. Despite the exceedingly large number of screening mammographies that are performed every year, to our knowledge subcutaneous breast tissue involvement as the sole presentation or of secondary spread of coccidioidomycosis has not been reported. We describe a patient who showed an unusual manifestation of a coccidioidal breast nodule simulating a neoplasm. The patient had been transiently immunosuppressed by prednisone therapy for presumptive temporal arteritis. 相似文献
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105.
K Fahmy A el-Gazar M Sammour M Nosair A Salem 《International journal of gynaecology and obstetrics》1991,34(2):133-137
Colposcopic examination was done in 189 successive parturients within 6-48 h of delivery for evidence of type, site, and extent of cervical trauma and its relation to various obstetric factors. There was trauma in 66% of cases, as erosion in 79%, as laceration in 56%, as bruising in 30%, and as yellow areas in 17%. In about two-thirds of cases, the diameter of cervical erosion, or the length of laceration did not exceed 5 mm and 81% of lacerations were of first degree. Cervical injury was significantly more frequent in primiparae, in the anterior cervical lip, in occipito-posterior positions, and with premature rupture of membranes. In 117 parturients with cervical injury another colposcopic examination was done 6-8 weeks postpartum. In 8% there was residual cervical damage. 相似文献
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107.
S. M. Rida N. S. Habib E. A. M. Badawey H. T. Y. Fahmy H. A. Ghozlan 《Archiv der Pharmazie》1995,328(4):325-328
2-[(4-Oxo-4,5-dihydrothiazol-2-yl)methyl]-1H-benzimidazole ( 2 ) was prepared through the reaction of 2-cyanomethyl-1H-benzimidazole ( 1 ) with thioglycolic acid. The syntheses of its arylidene 3 and diazo-coupled compounds 5 and the cyclization of the aforementioned thiazolylbenzimidazole to benzimidazolylthiazolo[3,2-a]pyridines 8 were also performed. The prepared compounds were screened for their in-vitro antibacterial, antifungal, anti-HIV, and anticancer activities: they show promising antifungal activity. 相似文献
108.
Spectrophotometric determination of cimetidine in the presence of its acid-induced degradation products 总被引:1,自引:0,他引:1
M M Bedair M A Elsayed M A Korany O T Fahmy 《Journal of pharmaceutical and biomedical analysis》1991,9(4):291-296
Cimetidine has been determined in the presence of its acid-induced degradation products using a second derivative (D2-) spectrophotometric method (method I) or a colorimetric method (method II). The former is based on D2-value measurement at 216 nm, whilst the latter depends on charge-transfer complexation with dichlorophenol-indophenol. The two methods are proved to be stability indicating, since plots of log C% versus time were linear. The application to cimetidine determination in tablets and ampoules gave good results. 相似文献
109.
110.
Investigation of the regenerative potential of necrotic mature teeth following different revascularisation protocols 下载免费PDF全文
Sarah Hossam Fahmy BDS MSc Ehab El Sayed Hassanien BDS MSc PhD Mohamed Mokhtar Nagy BDS MSc PhD Kariem Mostafa El Batouty BDS MSc PhD Mohamed Mekhemar DDS DrMedDent El Hassan Hassanein Jörg Wiltfang DDS DrMedDent Christof Dörfer DDS DrMedDent 《Australian endodontic journal : the journal of the Australian Society of Endodontology Inc》2017,43(2):73-82
This study aimed to assess the revascularisation potential of necrotic mature teeth in a dog model following different protocols. Periapical infection was induced in 54 mature premolars. Teeth were distributed into seven groups: (1) Double‐antibiotic‐paste/Blood clot, (2) Ciprofloxacin/collagen, (3) Double‐antibiotic‐paste/Collagen, (4) Modified Tri‐antibiotic‐paste /collagen, (5) Ciprofloxacin/Gelfoam, (6) Double‐antibiotic‐paste/Gelfoam, and (7) Modified Triantibiotic‐ paste/Gelfoam. Positive and negative controls included infected and healthy teeth, respectively, (n = 12 roots/group). Canals were apically shaped to size 0.6 mm then disinfected for 1 month. Intra‐canal bleeding was induced then scaffolds were applied for another month. Teeth and supporting bone were surgically sampled. Tissues were histologically scored and vimentin immuno‐intensity was estimated. Ciprofloxacin and Double‐antibiotic paste/Collagen resulted in significantly better corono‐apical tissue ingrowths, vascularity, cementum formation and significantly lower inflammatory extents (P < 0.05).These groups also showed significantly higher Vimentin intensities, (P < 0.05). The applied protocols revascularised necrotic mature canals and reduced inflammation particularly in the Ciprofloxacin/collagen and Double‐antibiotic‐paste/collagen groups. 相似文献