Caffeine in the milk prevents respiratory disorders caused by in utero caffeine exposure in rats

Consequences of postnatal caffeine exposure by the milk on ponto-medullary respiratory disturbances observed following an in utero caffeine exposure were analysed. Ponto-medullary-spinal cord preparations from newborn rats exposed to caffeine during gestation but not after the birth display an increase in respiratory frequency and an exaggeration of the hypoxic respiratory depression compared to not treated preparations. These data suggest that tachypneic and apneic episodes encountered in human newborns whose mother consumed caffeine during pregnancy are due in large part to central effect of caffeine at the ponto-medullary level. Both baseline respiratory frequency increase and emphasis of hypoxic respiratory depression are not encountered if rat dams consumed caffeine during nursing. Our hypothesis is that newborn rats exposed to caffeine during gestation but not after the birth would be in withdrawal situation whereas, when caffeine is present in drinking fluid of lactating dams, it goes down the milk and is able to prevent ponto-medullary respiratory disturbances.     

Erosive polyarthritis in Crohn's disease. Report of a case

Erosive polyarthritis in Crohn's disease is rare and raises diagnostic and pathophysiological problems. A case with destructive lesions of the shoulders and hips is reported in a 43-year-old woman with a 26-year history of Crohn's disease. Ankylosis of the spine and hips, motion range limitation of the shoulders and wrists, and boutonnière deformity of the third finger of the right hand were present. Tests were negative for rheumatoid factor and the HLA-B27 antigen. Plain radiographs showed a triple rail pattern at the spine; synostosis of the hips; and destructive lesions of the shoulders, wrists, tarsal bones, and third proximal interphalangeal joint of the right hand. Glucocorticoid therapy was effective in suppressing the bowel symptom flares but only partially improved the joint symptoms, whose treatment relied mainly on nonsteroidal antiinflammatory agents and rehabilitation therapy. Erosive arthritis in Crohn's disease is frequently monoarticular, with the hip being the most common target. It can complicate a spondylarthropathy or reveal granulomatous synovitis. Polyarticular forms pose difficult diagnostic and therapeutic challenges and add to the disability caused by the bowel disease. The potential role of genetic factors remains to be studied.     

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives

In the course of structure-activity relationship studies, diversely substituted 1-(beta- d-acetylatedglucopyranosyl)isoindigo derivatives were prepared from indolines. New 7'-azaisoindigo analogues were also synthesized by coupling a glycosylated isatine and a 7-azaindolin-2-one derivative. Compounds containing a 7'-azaisoindigo framework have never been described before. To get an insight into the substitution pattern required for the best biological potencies, their antiproliferative activities were evaluated toward a human buccal carcinoma cell line (KB) and two human myeloid leukaemia cell lines (K562, HL60).     

Concurrent validity of SMTEC footswitches system for the measurement of temporal gait parameters

The GAITRite system is a validated portable gait analysis system that allows simple objective gait measurements. The limited length of the active area of the GAITRite system may be a limitation in obtaining reliable measures of stride-to-stride variability. In contrast, the SMTEC footswitches system provides a continuous measurement of temporal step parameters for a long distance and a long period (around 24 h). The aim of the study was to examine the concurrent validity of the SMTEC footswitches system with the GAITRite system for the measurement of temporal steps parameters. Step, stride, swing and stance time were simultaneously recorded using SMTEC and GAITRite systems while walking at normal, slow and fast self-selected walking speed among 13 healthy young adults. The level of agreement between both systems was high as for the stride time with intra-class correlation coefficients (ICC) between 0.95 and 0.99 (P<0.001) and repeatability coefficients (RC) between 1.1% and 1.5% of mean values, whereas the lowest level of agreement was shown at fast self-selected walking speed and for stance time (ICC=0.52 with P<0.001 and RC=4.9%). Furthermore, the measurement of individual footstep data was excellent with an agreement ranging between -0.04 and 0.04 s (Pitman's test of difference in variance: r=-0.009, P=0.772). The present results suggest that the SMTEC footswitches system provides a valid and reliable measurement of temporal gait parameters in healthy young adults.     

Möbius syndrome

M?bius syndrome is a rare congenital disease characterized by facial and abducens nerve palsy. Children are unable to smile, frown, suck, grimace, blink their eyes, and to move their eyes laterally. The aim of this study was to analyze the diagnosis and treatment of this disease. Maxillofacial examination reveals: facial diplegia, retrognathism, palatine and dental malformations. M?bius syndrome is usually associated with multiple cranial nerve involvement, limb or orofacial malformation, and Poland syndrome. Although the pathogenesis of the syndrome is unclear, a number of mechanisms have been suggested including vascular and genetic hypotheses. Symptomatic treatment is used to manage this syndrome. The diagnosis of M?bius syndrome may be difficult in some patients with atypical signs of facial diplegia and other cranial nerve palsies, it requires a multidisciplinary approach.