全文获取类型
收费全文 | 722篇 |
免费 | 48篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 19篇 |
妇产科学 | 14篇 |
基础医学 | 84篇 |
口腔科学 | 60篇 |
临床医学 | 55篇 |
内科学 | 131篇 |
皮肤病学 | 10篇 |
神经病学 | 35篇 |
特种医学 | 18篇 |
外科学 | 128篇 |
综合类 | 18篇 |
预防医学 | 79篇 |
眼科学 | 30篇 |
药学 | 33篇 |
中国医学 | 13篇 |
肿瘤学 | 32篇 |
出版年
2023年 | 6篇 |
2022年 | 17篇 |
2021年 | 21篇 |
2020年 | 9篇 |
2019年 | 18篇 |
2018年 | 24篇 |
2017年 | 14篇 |
2016年 | 17篇 |
2015年 | 26篇 |
2014年 | 32篇 |
2013年 | 35篇 |
2012年 | 51篇 |
2011年 | 42篇 |
2010年 | 27篇 |
2009年 | 23篇 |
2008年 | 41篇 |
2007年 | 34篇 |
2006年 | 35篇 |
2005年 | 34篇 |
2004年 | 18篇 |
2003年 | 21篇 |
2002年 | 17篇 |
2001年 | 18篇 |
2000年 | 20篇 |
1999年 | 21篇 |
1998年 | 7篇 |
1997年 | 6篇 |
1995年 | 4篇 |
1993年 | 5篇 |
1992年 | 5篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 13篇 |
1987年 | 14篇 |
1986年 | 13篇 |
1985年 | 5篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 3篇 |
1970年 | 2篇 |
1968年 | 3篇 |
排序方式: 共有770条查询结果,搜索用时 15 毫秒
71.
72.
A retrospective clinical and radiologic study was made of 16 children with foot deformities and associated occult spinal abnormalities in a 3-year period. Eleven children had bilateral foot deformities; the deformities were unilateral in five. Midline cutaneous lesions of the back were noted in 13 children; the most common dermal sign was a hairy patch. All children had radiologic features of spinal dysraphism on combined computed tomography (CT) scan and myelogram. Spinal dysraphism was not considered in the initial assessment of four children. Children with foot deformity should therefore have a careful assessment of the spine, including a neurologic evaluation. 相似文献
73.
Twenty-seven children with vascular deficit associated with the displaced posterolateral type of supracondylar fracture were explored surgically. Twenty-two children had median nerve signs. Associated clinical findings were bruising, tethering or puckering of the skin in the antecubital region, and a palpable subcutaneous medial spike of the proximal humeral fragment, indicating that the brachialis muscle was penetrated. Manipulation was avoided in such cases. At exploration, the neurovascular bundle was found trapped anterior to the fracture edge in 18 cases, dislocated behind the fracture edge in five cases, and separated by the spike in four cases. Fasciotomy of the antecubital region was performed, and the neurovascular bundle was released from entrapment. The vessel pulsated after release in 21 cases, vascular procedures were done in four, and the vessel ends were ligated in two completely lacerated vessels. Manipulation should be avoided in displaced posterolateral supracondylar fractures with neurovascular deficit when there is clinical evidence that the brachialis muscle belly has been buttonholed. 相似文献
74.
Naicker S Fabian J Naidoo S Wadee S Paget G Goetsch S 《Seminars in immunopathology》2007,29(4):397-414
Glomerular injury, occurring either as primary glomerular disease or as part of a systemic disease process, is usually a result
of immune-mediated mechanisms. The morphologic reaction pattern has a diverse spectrum of appearance, ranging from normal
by light microscopy in minimal change disease to crescentic forms of glomerulonephritis, with conspicuous disruption of the
normal glomerular morphology. The mechanisms of glomerular immune deposit formation include trapping of circulating antigen–antibody
complexes and the in situ formation of immune complexes within the glomerulus. While the majority of postinfectious immune-complex-mediated
glomerulonephritides are believed to result from the deposition of circulating antigen–antibody complexes, preformed outside
of the kidney and secondarily deposited in the kidney, the notion of forming in situ antigen–antibody complexes to either
planted antigens or to integral structural components of the glomerulus, through “cross-reacting” autoimmune reactions, is
gaining popularity in a variety of forms of glomerulonephritides. Patients with HIV infection may develop a spectrum of renal
pathology, the glomerular manifestations of which include both antigen–antibody complex and nonimmune-complex-mediated pathogenetic
mechanisms. Similarly, patients with Streptococcal infections, Hepatitis B virus, or Hepatitis C virus infection may develop
a spectrum of glomerulonephritides, which are predominantly immune-complex-mediated. Therapy for glomerular diseases due to
HIV, hepatitis B, or C virus infections remains a challenge. 相似文献
75.
This paper examines the complex interconnections between the development of health promotion and multidisciplinary public health, respectively. Health promotion takes a distinctive interdisciplinary and multiprofessional perspective on health. Historically, it has brought together practitioners from varied disciplinary backgrounds, education and training. It therefore brings real advantages to the public health enterprise, where the goal is to bridge organisations, professions and partners to collectively address key determinants of health in the most effective manner. This paper debates the contribution health promotion has made to the development of multidisciplinary public health over the past 30 years and explores the principles, values, professional bases and practices of both. It is argued that health promotion's contribution to the development of 'the new public health' was critical, while its status and role within multidisciplinary public health remain problematic and unresolved. The nature of these dilemmas is discussed, reflecting on missed opportunities and possible resolutions. 相似文献
76.
Food insecurity partially mediates associations between social disadvantage and body composition among older adults in india: Results from the study on global AGEing and adult health (SAGE) 下载免费PDF全文
77.
Namrita Lall Navneet Kishore Saeideh Momtaz Ahmed Hussein Sanushka Naidoo Mabatho Nqephe Bridget Crampton 《Phytotherapy research : PTR》2015,29(11):1729-1736
Skin hyper‐pigmentation is a condition initiated by the overproduction of melanin existing in the melanocytes. Melanin pigment is responsible for the colour of skin in humans. It is formed through a series of oxidative reactions involving the amino acid tyrosine in the presence of the key enzyme tyrosinase. In continuation with our efforts to identify tyrosinase inhibitors from plants sources, the methanol extract from leaf, bark and fruit of Ceratonia siliqua were screened for tyrosinase inhibition and diphenolase activity. The bark extract exhibited significant inhibition on mushroom tyrosinase using L‐tyrosine as a substrate and showed diphenolase activity. The extract further significantly lowered tyrosinase mRNA levels in B16‐F10 mouse melanocytes. Bioassay‐guided fractionation led to the isolation of six compounds. Compounds (?)‐epicatechin‐3‐O‐gallate, 1,2,3,6‐tetra‐O‐galloyl‐ß‐D‐glucose and gallocatechin‐3‐O‐gallate showed tyrosinase inhibitions with the IC50 values of 27.52, 83.30 and 28.30 µg/mL, respectively. These compounds also exhibited L‐DOPA activities with IC50 values of >200, 150 and 200 µg/mL, respectively. A clinical study was conducted using 20 volunteers in a patch testing trial for irritancy potential and skin depigmentation. The clinical results showed the sample to be non‐irritant with irritancy potential of ?34.21 and depigmentation trial showed an improvement in the even skin tone of UV induced pigmentation at 3% after 28 days of application. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
78.
Background: In severe mitral regurgitation, a subset of patients who are asymptomatic may develop left ventricular decompensation before changes in echocardiographic parameters become evident. Since N-terminal brain natriuretic peptide (NT-proBNP) is used to detect early heart failure, we hypothesised that NT-proBNP would be activated in patients with mitral regurgitation. Methods: Patients submitted to surgery were prospectively evaluated over eight months in the Department of Cardiology at Inkosi Albert Luthuli Central Hospital. Control patients with severe mitral regurgitation were obtained from the outpatient clinic. In order to define their value in identifying left ventricular decompensation, NT-proBNP levels and tissue Doppler imaging (TDI) indices were simultaneously measured and compared with conventional echocardiographic indices at baseline and this was repeated at one week and at six weeks after valve replacement. Results: Mean NT-proBNP levels were markedly elevated pre-operatively in all surgical cases compared to controls (p = 0.0001). The diastolic E-mitral/E-annulus ratio, measured using TDI, was higher in the study group, indicating higher left ventricular filling pressure present in the study group. NT-proBNP levels increased further at one week after surgery and subsided at the six-week follow-up visit to levels similar to the control group. The TDI diastolic ratio also decreased at one week, and increased slightly again at the six-week follow up. These changes were accompanied by significant reduction in left atrium and left ventricular chamber dimensions with an increase in the ejection fraction from one to six weeks. Conclusion: Marked differences in mean NT-proBNP levels and TDI ratios between the study and control groups suggest that using TDI and NT-proBNP assays may detect covert left ventricular decompensation. 相似文献
79.
80.
TR Fricke BA Holden DA Wilson G Schlenther KS Naidoo S Resnikoff KD Frick 《Bulletin of the World Health Organization》2012,90(10):728-738