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排序方式: 共有1034条查询结果,搜索用时 16 毫秒
991.
Teyton L Apostolopoulos V Cantu C Celia H Mallet-Désigné V Stefanko R Stramann T Wallace M 《Immunologic research》2000,21(2-3):325-330
The engagement of the T cell receptor (TCR) to its ligand, the major histocompatibility complex (MHC)-peptide complex, leads
to T cell activation. The molecular mechanisms leading to this activation are still unknown. Dimerization or substantial conformational
changes following TCR ligation have not been observed by classical biochemical methods or by X-ray crystallography of the
TCR/MHC complex. However, most of these experiments have used reductionist approaches in which only MHC and TCR molecules
were taken into account. In fact, the TCR is only one of many molecules forming the TCR complex (TCRC), and the interplay
among the components of this larger complex have not been studied in depth. The reconstitution of a complete TCRC using recombinant
molecules is our goal and will be the first step to new structural and functional studies. 相似文献
992.
Jake G. Natalini Joshua M. Diamond Mary K. Porteous David J. Lederer Keith M. Wille Ann B. Weinacker Jonathan B. Orens Pali D. Shah Vibha N. Lama John F. McDyer Laurie D. Snyder Chadi A. Hage Jonathan P. Singer Lorraine B. Ware Edward Cantu Michelle Oyster Laurel Kalman Jason D. Christie Elana J. Bernstein 《The Journal of heart and lung transplantation》2021,40(5):351-358
993.
Mariana Herrera Lilien Chertkoff Ethel Palavecino Alicia Mota Maria del Carmen Guala Leonardo Fainboim M.Leonardo Satz 《Human immunology》1989,26(4):272-280
In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be significantly increased among North Americans celiac disease patients of the DR3,DQw2 haplotype was found with similar frequency in Latin-American control and celiac disease individuals. A DPA/BglII 3.7-kb fragment previously shown to be increased among British celiac disease patients was also present with similar frequency among Latin-American control and celiac disease individuals. These results show that the frequency of the HLA-DP region-derived restriction fragment length polymorphisms linked to celiac disease differs between Caucasian populations of different ethnic backgrounds (Anglo-Saxon and Latin-American). On the other hand, DNA samples from 13 patients and 14 controls bearing the DR5/DR7 phenotype (which is significantly associated with celiac disease in Latin populations) were investigated for the presence of particular restriction fragment length polymorphisms disproportionally present in celiac disease individuals. No significant differences were found between controls and patients when the DNA was analyzed with 10 different restriction enzymes and probes for DRB, DQA, DQB, and DPB HLA class II sequences. 相似文献
994.
Role of hsp60 during Autoimmune and Bacterial Inflammation 总被引:9,自引:0,他引:9
995.
Forslund O Antonsson A Higgins G Ly H Delius H Hunziker A de Villiers EM 《Virology》2003,312(2):255-260
From a basal cell carcinoma (BCC) the complete genome of candidate human papillomavirus (HPV) type 92 was characterized. Phylogenetically, the candidate HPV 92 was relatively distantly related to other cutaneous HPV types within the B1 group. By quantitative real time PCR, 94 viral copies were present per cell in the BCC and another BCC contained 1 viral copy per cell. Lower copy numbers were found in two solar keratoses (1 copy per 33 cells and 1 copy per 60 cells) and two squamous cell carcinomas (1 copy per 436 cells and 1 copy per 1143 cells). The high viral load of HPV 92 in two BCCs differs from the low amount of HPV DNA reported from nonmelanoma skin cancers. 相似文献
996.
Sir-Petermann T Hitchsfeld C Maliqueo M Codner E Echiburú B Gazitúa R Recabarren S Cassorla F 《Human reproduction (Oxford, England)》2005,20(8):2122-2126
BACKGROUND: A relationship between reduced fetal growth and the polycystic ovary syndrome (PCOS) has been proposed in girls with PCOS. However, the birth weight in the offspring of PCOS mothers has not been systematically investigated. The aim of this study was to establish the birth weight of newborns of mothers with PCOS and to compare it with a control group of newborns of normal women matched by age and weight at the beginning of pregnancy. METHODS: The birth weight of 47 infants born from singleton pregnancies in women with well-documented PCOS was compared with 180 infants born from singleton pregnancies in healthy controls. RESULTS: The prevalence of small for gestational age (SGA) infants was significantly higher in the PCOS group compared to the control group (12. 8% versus 2.8%, respectively, P<0.02). Moreover, SGA infants born to PCOS mothers were smaller than those born to control mothers (P<0.05). The prevalence of large for gestational age infants (LGA) was similar in both groups, but birth length of LGA newborns was greater in PCOS women than controls (P<0.05). CONCLUSIONS: PCOS mothers showed a significantly higher prevalence of SGA newborns which cannot be completely attributed to pregnancy complications, and seems to be more related to the PCOS condition of the mother. 相似文献
997.
998.
999.
Alberto Daniel Guerra David Antonio Cantu Joseph T. Vecchi Warren E. Rose Peiman Hematti Weiyuan John Kao 《The AAPS journal》2015,17(3):620-630
Mesenchymal stromal/stem cells (MSCs) have demonstrated favorable wound healing properties in addition to their differentiation capacity. MSCs encapsulated in biomaterials such as gelatin and polyethylene glycol (PEG) composite hydrogels have displayed an immunophenotype change that leads to the release of cytokines and growth factors to accelerate wound healing. However, therapeutic potential of implanted MSC-loaded hydrogels may be limited by non-specific protein adsorption that facilitates adhesion of bacterial pathogens such as planktonic Staphylococcus aureus (SA) to the surface with subsequent biofilm formation resistant to immune cell recognition and antibiotic activity. In this study, we demonstrate that blood-derived primary leukocytes and bone marrow-derived MSCs cannot inhibit colony-forming abilities of planktonic or biofilm-associated SA. However, we show that hydrogels loaded with MSCs and minocycline significantly inhibit colony-forming abilities of planktonic SA while maintaining MSC viability and multipotency. Our results suggest that minocycline and MSC-loaded hydrogels may decrease the bioburden of SA at implant sites in wounds, and may improve the wound healing capabilities of MSC-loaded hydrogels.
Electronic supplementary material
The online version of this article (doi:10.1208/s12248-015-9728-6) contains supplementary material, which is available to authorized users.KEY WORDS: hydrogel, leukocytes, mesenchymal stromal/stem cells, minocycline, Staphylococcus aureus 相似文献1000.
Cristina Fugazza Gloria Barbarani Sudharshan Elangovan Maria Giuseppina Marini Serena Giolitto Isaura Font-Monclus Maria Franca Marongiu Laura Manunza John Strouboulis Claudio Cantu Fabio Gasparri Silvia M.L. Barabino Yukio Nakamura Sergio Ottolenghi Paolo Moi Antonella Ellena Ronchi 《Haematologica》2021,106(2):474