全文获取类型
收费全文 | 879篇 |
免费 | 46篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 29篇 |
妇产科学 | 23篇 |
基础医学 | 62篇 |
口腔科学 | 33篇 |
临床医学 | 84篇 |
内科学 | 229篇 |
皮肤病学 | 76篇 |
神经病学 | 51篇 |
特种医学 | 26篇 |
外科学 | 154篇 |
综合类 | 12篇 |
预防医学 | 24篇 |
眼科学 | 69篇 |
药学 | 15篇 |
中国医学 | 2篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 4篇 |
2022年 | 21篇 |
2021年 | 20篇 |
2020年 | 15篇 |
2019年 | 22篇 |
2018年 | 28篇 |
2017年 | 17篇 |
2016年 | 32篇 |
2015年 | 46篇 |
2014年 | 42篇 |
2013年 | 49篇 |
2012年 | 55篇 |
2011年 | 81篇 |
2010年 | 46篇 |
2009年 | 25篇 |
2008年 | 41篇 |
2007年 | 62篇 |
2006年 | 63篇 |
2005年 | 54篇 |
2004年 | 47篇 |
2003年 | 27篇 |
2002年 | 33篇 |
2001年 | 13篇 |
2000年 | 16篇 |
1999年 | 9篇 |
1998年 | 7篇 |
1997年 | 11篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 2篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1968年 | 1篇 |
1958年 | 1篇 |
1956年 | 1篇 |
1955年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有928条查询结果,搜索用时 15 毫秒
31.
32.
Sonia Christian Saad Arain Pritesh Patel Irum Khan Gregory S. Calip Vaibhav Agrawal Karen Sweiss Shawn Griffin Kirk Cahill Heiko Konig Aysenur Esen Ardaman Shergill Olatoyosi Odenike Wendy Stock John G. Quigley 《American journal of hematology》2020,95(8):937-943
Relapsed or refractory acute myeloid leukemia (R/R AML) has a poor prognosis and is best treated with salvage chemotherapy as a bridge to allogeneic stem cell transplant (alloSCT). However, the optimal salvage therapy remains unknown. Here we compared two salvage regimens; mitoxantrone, etoposide, and cytarabine (MEC) and mitoxantrone and high-dose Ara-C (Ara-C couplets). We analyzed 155 patients treated at three academic institutions between 1998 and 2017; 87 patients received MEC and 68 received Ara-C couplets. The primary endpoint was overall response (OR). Secondary endpoints included progression-free survival (PFS), overall survival (OS), duration of hospitalization, hematologic and nonhematologic toxicities, and success in proceeding to alloSCT. Baseline characteristics of the cohorts were well matched, though patients receiving Ara-C couplets had more co-morbidities (48.5% vs 33%; P = .07). OR was achieved in 43.7% of MEC and 54.4% of Ara-C couplets patients (P = .10). Ara-C couplets patients also trended towards a longer OS and PFS, more frequently proceeded to alloSCT (31% vs 54.4%; P = .003), and experienced less febrile neutropenia (94% vs 72%; P < .001) and grade 3/4 gastrointestinal toxicities (17.2% vs 2.94%; P = .005). No significant differences in other toxicities or median duration of hospitalization were noted. This is the first multi-institutional study directly comparing these regimens in a racially diverse population of R/R AML patients. Although these regimens have equivalent efficacy in terms of achieving OR, Ara-C couplets use is associated with significant reductions in toxicities, suggesting it should be used more frequently in these patients. 相似文献
33.
Sevim Şahin Ali Cansu Tülay Kamaşak İlker Eyüboğlu Gülnur Esenülkü Ayşenur Ökten 《Child's nervous system》2014,30(12):2139-2142
Background
Infections are an important acquired cause of cerebral arteriopathy. Tuberculous (TB) meningitis leading to infectious cerebral vasculopathy is a rare cause of acute hemiparesis.Case report
A 14-year-old male patient was examined after acute hemiparesis developing within 1 day. Neurological examination revealed total hemiplegia on the left side. Brain MRI findings showed bilateral focal T2-weighted signal hyperintensity in the subcortical and deep white matter regions. There were also areas of restricted diffusion in the right basal ganglia. Although the father had a history of pulmonary TB, the patient had not been given TB prophylaxis because of PPD negativity. At lumbar puncture, opening cerebrospinal fluid (CSF) pressure was 50 cm/H20, CSF protein 66.9 mg/dL, and glucose 54 mg/dL (concurrent blood glucose 93 mg/dL); 170 polymorphonuclear leukocytes per cubic millimeter were present in CSF. Following tests for TB, treatment was started immediately with four anti-TB drugs. TB PCR of CSF and acid-fast bacteria (AFB) staining in gastric aspirate were positive. At clinical follow-up, the patient was able to walk with support at the end of the first month.Conclusion
Various infectious agents have been reported as causes of cerebral vasculopathy. TB, which affects a significant number of patients worldwide, should be kept in mind in terms of cerebral vascular complications. Lumbar puncture is essential in order to diagnose TB meningitis. 相似文献34.
35.
Una D. McCann Zsolt Szabo Melin Vranesic Esen Seckin Gary Wand Anna DuVal Robert F. Dannals George A. Ricaurte 《Molecular imaging and biology》2007,9(3):151-157
Purpose The appetite suppressants fenfluramine and dexfenfluramine were widely prescribed before being withdrawn from the market in
1997. Both drugs are known to have the potential to damage brain serotonin (5-HT) axons and axon terminals in animals, including
nonhuman primates. This study used quantitative positron emission tomography (PET) with [11C] McN5652, a serotonin transporter (SERT) ligand to determine whether humans previously exposed to fenfluramines showed reductions
in SERT binding parameters.
Procedures Subjects previously treated with fenfluramines for weight loss (N = 15) and age-matched controls (N = 17) underwent PET studies with [11C] McN5652. Global and regional distribution volumes (DVs) of [11C] McN5652 were compared in the two subject groups using parametric statistical analyses.
Results Compared to controls, subjects previously exposed to fenfluramines had significant reductions in [11C]McN5652 binding in 14 of 15 regions of interest, more than four years after drug discontinuation.
Conclusions These results are the first to provide direct evidence for fenfluramine-induced 5-HT neurotoxicity in humans. 相似文献
36.
Can Yücel Karabay M.D. Regayip Zehir M.D. Ahmet Güler M.D. Vecih Oduncu M.D. Arzu Kalayci M.D. Soe Moe Aung M.D. Ali Karagoz M.D. Ibrahim Halil Tanboga M.D. Ozkan Candan M.D. Cetin Gecmen M.D. Ayhan Erkol M.D. Ali Metin Esen M.D. Cevat Kirma M.D. 《Echocardiography (Mount Kisco, N.Y.)》2013,30(5):572-581
The aim of this study was to evaluate left atrial deformations using speckle tracking echocardiography for predicting left atrial appendage (LAA) thrombus in patients with suspected cardioembolic stroke who were in normal sinus rhythm. A total of 153 ischemic stroke patients (89 males, 64 females) in sinus rhythm who were suspected of having cardioembolism were included in the study. The patients underwent conventional two‐dimensional (2D) echocardiogram and 2D speckle tracking echocardiogram of the left atrium. Left atrial peak strain (LA‐4C‐RES) and left atrial precontraction strain (LA‐4C‐PUMP) were measured. Patients were divided into 2 groups according to the presence of thrombus in the LAA in transesophageal echocardiography. Both LA‐4C‐RES and LA‐4C‐PUMP values were found to be significantly lower in patients with LAA thrombus (11.8 ± 1.4% vs. 33 ± 12%, P < 0.001 and 5.8 ± 1.3% vs. 14.2 ± 5.3%, P < 0.001, respectively). A good inverse correlation was present between LA‐4C‐RES values and LAA morphologic parameters (with LAA area: r = ?0.70, P < 0.001, with LAA length: r = ?0.60, P < 0.001), and a good positive correlation was present with LAA emptying velocity with pulse Doppler (r = 0.74, P < 0.001). The area under the receiver‐operating characteristic curve of the LA‐4C‐RES was 0.94 (0.90–0.98, P < 0.001), for the LA‐4C‐PUMP, the area was 0.92 (0.87–0.96, P < 0.001) to predict LAA thrombus. Left atrial deformation parameters measured by 2D speckle tracking method was found to predict impaired LAA functions and the presence of LAA thrombus in ischemic stroke patients with suspected cardioembolism, but who are in sinus rhythm. 相似文献
37.
Aylin Babalik Ismail Hakki Ulus Nadi Bakirci Tulin Kuyucu Huseyin Arpag Lale Dagyildizi Esen Capaner 《Antimicrobial agents and chemotherapy》2013,57(11):5740-5742
Plasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49% or 100% (P < 0.01), 66% or 100% (P < 0.05), 30% or 50% (P = 0.198), and 32% or 21% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients. 相似文献
38.
SUMMARY: BACKGROUND: Fibroadenomas are common neoplasms in young women but occur in a wide age range from adolescent females to octogenians. CASE REPORT: A 21-year-old female patient presented with a 10-week history of a mass in her breast. Ultrasound examination demonstrated a 3.5 × 3 cm, well-circumscribed, semisolid mass. An excisional biopsy but no fine needle aspiration was performed. The patient had no history of pregnancy or lactation, or trauma or infection to the area of the lesion. The histopathological examination showed a spontaneously infarcted fibroadenoma. CONCLUSIONS: Spontaneous infarction is an uncommon complication in fibroadenoma of the breast, and there are very few reported cases in the literature. 相似文献
39.
40.
Reliability of procalcitonin as a severity marker in critically ill patients with inflammatory response 总被引:5,自引:0,他引:5
Tugrul S Esen F Celebi S Ozcan PE Akinci O Cakar N Telci L 《Anaesthesia and intensive care》2002,30(6):747-754
Procalcitonin (PCT) is increasingly recognised as an important diagnostic parameter in clinical evaluation of the critically ill. This prospective study was designed to investigate PCT as a diagnostic marker of infection in critically ill patients with sepsis. Eighty-five adult ICU patients were studied. Four groups were defined on the basis of clinical, laboratory and bacteriologic findings as systemic inflammatory response syndrome (SIRS) (n = 10), sepsis (n = 16), severe sepsis (n = 18) and septic shock (n = 41). Data were collected including C-reactive protein (CRP), PCT levels and Sequential Organ Failure Assessment and Acute Physiology and Chronic Health Evaluation II scores on each ICU day. PCT levels were significantly higher in patients with severe sepsis and septic shock (19.25 +/- 43.08 and 37.15 +/- 61.39 ng/ml) than patients with SIRS (0.73 +/- 1.37 ng/ml) (P < 0.05 for each comparison). As compared with SIRS patients, plasma PCT levels were significantly higher in infected patients (21.9 +/- 47.8 ng/ml), regardless of the degree of sepsis (P < 0.001). PCT showed a higher sensitivity (73% versus 35%) and specificity (83% versus 42%) compared to CRP in identifying infection as a cause of the inflammatory response. Best cut-off levels were 1.31 ng/ml for PCT and 13.9 mg/dl for CRP. We suggest that PCT is a more reliable marker than CRP in defining infection as a cause of systemic inflammatory response. 相似文献