全文获取类型
收费全文 | 822篇 |
免费 | 45篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 28篇 |
妇产科学 | 12篇 |
基础医学 | 115篇 |
口腔科学 | 12篇 |
临床医学 | 84篇 |
内科学 | 151篇 |
皮肤病学 | 23篇 |
神经病学 | 34篇 |
特种医学 | 171篇 |
外科学 | 31篇 |
综合类 | 8篇 |
预防医学 | 144篇 |
药学 | 17篇 |
中国医学 | 3篇 |
肿瘤学 | 38篇 |
出版年
2022年 | 5篇 |
2021年 | 7篇 |
2020年 | 4篇 |
2019年 | 8篇 |
2016年 | 12篇 |
2015年 | 7篇 |
2014年 | 12篇 |
2013年 | 33篇 |
2012年 | 28篇 |
2011年 | 25篇 |
2010年 | 16篇 |
2009年 | 24篇 |
2008年 | 29篇 |
2007年 | 57篇 |
2006年 | 29篇 |
2005年 | 25篇 |
2004年 | 31篇 |
2003年 | 18篇 |
2002年 | 20篇 |
2001年 | 13篇 |
2000年 | 21篇 |
1999年 | 19篇 |
1998年 | 18篇 |
1997年 | 29篇 |
1996年 | 30篇 |
1995年 | 21篇 |
1994年 | 21篇 |
1993年 | 17篇 |
1992年 | 12篇 |
1991年 | 18篇 |
1990年 | 18篇 |
1989年 | 36篇 |
1988年 | 18篇 |
1987年 | 28篇 |
1986年 | 26篇 |
1985年 | 31篇 |
1984年 | 21篇 |
1983年 | 10篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 9篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1976年 | 3篇 |
1975年 | 9篇 |
1974年 | 4篇 |
1970年 | 5篇 |
1967年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有879条查询结果,搜索用时 15 毫秒
101.
Susanne S. Pedersen Johan Denollet Ruud A. M. Erdman Patrick W. Serruys Ron T. van Domburg 《Journal of behavioral medicine》2009,32(3):294-301
We examined the impact of co-occurring diabetes and hopelessness on 3-year prognosis in percutaneous coronary intervention
patients. Consecutive patients (n = 534) treated with the paclitaxel-eluting stent completed a set of questionnaires at baseline and were followed up for 3-year
adverse clinical events. The incidence of 3-year death/non-fatal myocardial infarction was 3.5% in patients with no risk factors
(neither hopelessness nor diabetes), 8.2% in patients with diabetes, 11.2% in patients with high hopelessness, and 15.9% in
patients with both factors (p = 0.001). Patients with hopelessness (HR: 3.28; 95% CI: 1.49–7.23) and co-occurring diabetes and hopelessness (HR: 4.89;
95% CI: 1.86–12.85) were at increased risk of 3-year adverse clinical events compared to patients with no risk factors, whereas
patients with diabetes were at a clinically relevant but not statistically significant risk (HR: 2.40; 95% CI: 0.82–7.01).
These results remained, adjusting for baseline characteristics and depressive symptoms. These findings testify to the importance
of identifying patients with co-occurring risk factors, as they likely require special management in clinical practice in
addition to standard medical treatment. 相似文献
102.
103.
104.
Canene-Adams K Lindshield BL Wang S Jeffery EH Clinton SK Erdman JW 《Cancer research》2007,67(2):836-843
The consumption of diets containing 5 to 10 servings of fruits and vegetables daily is the foundation of public health recommendations for cancer prevention, yet this concept has not been tested in experimental models of prostate cancer. We evaluated combinations of tomato and broccoli in the Dunning R3327-H prostate adenocarcinoma model. Male Copenhagen rats (n=206) were fed diets containing 10% tomato, 10% broccoli, 5% tomato plus 5% broccoli (5:5 combination), 10% tomato plus 10% broccoli (10:10 combination) powders, or lycopene (23 or 224 nmol/g diet) for approximately 22 weeks starting 1 month prior to receiving s.c. tumor implants. We compared the effects of diet to surgical castration (2 weeks before termination) or finasteride (5 mg/kg body weight orally, 6 d/wk). Castration reduced prostate weights, tumor areas, and tumor weight (62%, P<0.001), whereas finasteride reduced prostate weights (P<0.0001), but had no effect on tumor area or weight. Lycopene at 23 or 224 nmol/g of the diet insignificantly reduced tumor weights by 7% or 18%, respectively, whereas tomato reduced tumor weight by 34% (P<0.05). Broccoli decreased tumor weights by 42% (P<0.01) whereas the 10:10 combination caused a 52% decrease (P<0.001). Tumor growth reductions were associated with reduced proliferation and increased apoptosis, as quantified by proliferating cell nuclear antigen immunohistochemistry and the ApopTag assay. The combination of tomato and broccoli was more effective at slowing tumor growth than either tomato or broccoli alone and supports the public health recommendations to increase the intake of a variety of plant components. 相似文献
105.
DD Cohen C Voss MJD Taylor DM Stasinopoulos A Delextrat GRH Sandercock 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(7):1065-1072
Aims: The aims of this study were to evaluate patterns of handgrip (HG) strength in relation to gender and age in English schoolchildren and to compare this with existing data and produce reference data for this population. Methods: The HG of 7147 English schoolchildren (3773 boys and 3374 girls) aged 10–15.9 years was measured using a portable Takei handgrip dynamometer (Takei Scientific Instruments Co. Ltd, Tokyo, Japan). Centile data were produced using the Generalized Additive Models for Location, Scale and Shape. Z‐scores were generated using existing data for European children. Age and gender interactions were analysed using analysis of covariance. Results: In boys and girls, significant increases in HG were found between every age‐group (p < 0.001). Boys were significantly stronger than girls at every age (p < 0.001) and the boys’ age‐related increase was significantly greater than the girls’ (p < 0.001). Conclusion: This study provides reference data for handgrip strength in English schoolchildren. Handgrip strength in English children is broadly similar to existing European data, after adjusting for mass and stature. These data could be used for clinical or athletic screening of low and high strength in this population. 相似文献
106.
Blueberries are rich in health-promoting polyphenolic compounds including proanthocyanidins. The purpose of this study was to determine if proanthocyanidin-rich fractions from both wild and cultivated blueberry fruit have the same inhibitory effects on the proliferation of LNCaP, an androgen-sensitive prostate cancer cell line, and DU145, a more aggressive androgen insensitive prostate cancer cell line. When 20 μg/ml of a wild blueberry proanthocyanidin fraction (fraction 5) was added to LNCaP media, growth was inhibited to 11% of control with an IC50 of 13.3 μg/ml. Two similar proanthocyanidin-rich fractions from cultivated blueberries (fractions 4 and 5) at the same concentration inhibited LNCaP growth to 57 and 26% of control with an IC50 of 22.7 and 5.8 μg/ml, respectively. In DU145 cells, the only fraction that significantly reduced growth compared to control was fraction 4 from cultivated blueberries with an IC50 value of 74.4 μg/ml, indicating only minor inhibitory activity. Differences in cell growth inhibition of LNCaP and DU145 cell lines by blueberry fractions rich in proanthocyanidins indicate that blueberry proanthocyanidins have an effect primarily on androgen-dependant growth of prostate cancer cells. Possible molecular mechanisms for growth inhibition are reviewed. 相似文献
107.
S H Erdman M H Hart J H Park J A Vanderhoof 《Journal of pediatric gastroenterology and nutrition》1991,13(4):360-366
The in vivo absorption of 3-O-methyl-D-glucose (3MG) as a marker of intestinal function has not been studied in an animal model. We evaluated the use of 3MG as a marker of intestinal absorption when given enterally to rats recovering from small bowel mucosal injury induced by methotrexate (MTX). Radiolabeled 3MG was administered into the duodenum of control (CON) and MTX-treated rats and blood samples were obtained at specified intervals. Mucosal permeability was also assessed using radiolabeled mannitol and polyethylene glycol 900 (PEG). Concentration time points were plotted, and area under the curve was calculated as an approximation of absorbed dose. Mucosal weight, maltase activity, and protein content were determined on mucosal scrapings. During the acute phase (day 5), 3MG absorption and maltase-specific activity were significantly decreased in the MTX group when compared to the CON group (p less than 0.001). The MTX group showed a trend toward greater permeability to mannitol when compared to the CON group; however, this was not statistically significant. Mucosal permeability to PEG was similar in both groups. During a later stage in the recovery process (day 12), the area under the curve calculations for 3MG absorption were the same for both CON and MTX animals, with maltase activity in the MTX group recovering to control values. Changes in 3MG absorption paralleled total maltase activities following severe injury. These results suggest that the combined active and passive transport of 3MG in vivo could be of use as a marker of intestinal absorption in states where the small intestine has sustained major damage resulting in compromised absorption as well as brush border digestion. 相似文献
108.
109.
Injury surveillance in agriculture 总被引:1,自引:0,他引:1
110.