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991.
Tong Xu Hong-Tao Li Jenny Wei Meng Li Tien-Chan Hsieh Yi-Tsung Lu Ranjani Lakshminarasimhan Rong Xu Emmanuelle Hodara Gareth Morrison Hemant Gujar Suhn Kyong Rhie Kimberly Siegmund Gangning Liang Amir Goldkorn 《International journal of cancer. Journal international du cancer》2020,146(11):3065-3076
Highly tumorigenic, drug-resistant cancer stem-like cells drive cancer progression. These aggressive cells can arise repeatedly from bulk tumor cells independently of mutational events, suggesting an epigenetic mechanism. To test this possibility, we studied bladder cancer cells as they cyclically shifted to and from a cancer stem-like phenotype, and we discovered that these two states exhibit distinct DNA methylation and chromatin accessibility. Most differential chromatin accessibility was independent of methylation and affected the expression of driver genes such as E2F3, a cell cycle regulator associated with aggressive bladder cancer. Cancer stem-like cells exhibited increased E2F3 promoter accessibility and increased E2F3 expression that drove cell migration, invasiveness and drug resistance. Epigenetic interference using a DNA methylation inhibitor blocked the transition to a cancer stem-like state and reduced E2F3 expression. Our findings indicate that epigenetic plasticity plays a key role in the transition to and from an aggressive, drug-resistant phenotype. 相似文献
992.
Zech NH Lejeune B Puissant F Vanderzwalmen S Zech H Vanderzwalmen P 《Fertility and sterility》2007,88(1):244-246
To determine the best day for the selection and transfer of a single embryo, a prospective, randomized study was undertaken that compared the ongoing pregnancy rate (PR) after single embryo transfer (SET) on day 3 with that after single blastocyst transfer (SBT) on day 5. Our results show an overall significantly higher PR after SBT (32.8%) compared with SET (23.2%), and a PR of 40.8% after SBT versus 25.6% after excellent-quality embryos became available. 相似文献
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de Ponfilly Gauthier Péan Lourtet-Hascoet Julie Porcheret Huong Cambau Emmanuelle Le Monnier Alban Jacquier Hervé Vasse Marc Farfour Eric 《European journal of clinical microbiology & infectious diseases》2021,40(10):2087-2093
European Journal of Clinical Microbiology & Infectious Diseases - Patients with viral respiratory infections often present symptoms compatible with bloodstream infections. Consequently, the... 相似文献
996.
Michael Stürzl Cornelia Blasig Anneliese Schreier Frank Neipel Christine Hohenadl Emmanuelle Cornali Gudrun Ascherl Stefan Esser Norbert H. Brockmeyer Marianne Ekman Ephata E. Kaaya Erwin Tschachler Peter Biberfeld 《International journal of cancer. Journal international du cancer》1997,72(1):68-71
Analysis by polymerase chain reaction (PCR) and serological studies have demonstrated a close association between the novel human herpes virus, Kaposi's sarcoma-associated herpes virus (KSHV) or human herpes virus-8 (HHV-8) and the development of Kaposi's sarcoma (KS). To clarify the role of HHV-8 in KS pathogenesis, we investigated at the cellular level by in situ hybridization the expression of a recently described 0.7-kb HHV-8-encoded mRNA (T0.7 mRNA) in KS tissues of different epidemiological origin (AIDS-KS, African endemic KS and classical KS). The T0.7 mRNA likely encodes a small membrane protein, supposedly expressed in latently HHV-8-infected cells. Indeed, we detected T0.7 mRNA in virtually all cells of the cell line BCBL-1 established from a body cavity-based lymphoma (BCBL) and latently infected with HHV-8. In all KS biopsies examined, independent of their epidemiological type, the late-stage (nodular) KS tissues showed a high level of T0.7 mRNA expression in typical KS spindle cells but also in endothelial cells lining blood vessels, indicating latent HHV-8 infection of these cells. The presence of T0.7-expressing cells was restricted to KS tumor tissue and therefore appears to indicate an important role of latent HHV-8 infection in KS pathogenesis. Int. J. Cancer 72:68–71, 1997. © 1997 Wiley-Liss Inc. 相似文献
997.
Bodil Edman Ahlbom Peter Goetz Julie R. Korenberg Ulf Pettersson Eva Seemanova Claes Wadelius Lore Zech Gran Annern 《American journal of medical genetics. Part A》1996,63(4):566-572
Down syndrome (DS) is caused in most cases by the presence of an extra chromosome 21. It has been shown that the DS phenotype is produced by duplication of only a small part of the long arm of chromosome 21, the 21q22 region, including and distal to locus D21S55. We present molecular investigations on a woman with clinically typical DS but apparently normal chromosomes. Her parents were consanguineous and she had a sister with a DS phenotype, who died at the age of 15 days. Repeated cytogenetic investigations (G-banding and high resolution banding) on the patient and her parents showed apparently normal chromosomes. Autoradiographs of quantitative Southern blots of DNAs from the patient, her parents, trisomy 21 patients, and normal controls were analyzed after hybridization with unique DNA sequences regionally mapped on chromosome 21. Sequences D21S59, D21S1, D21S11, D21S8, D21S17, D21S55, ERG, D21S15, D21S112, and COL6A1 were all found in two copies. Fluorescent in situ hybridization with a chromosome 21-specific genomic library showed no abnormalities and only two copies of chromosome 21 were detected. Nineteen markers from the critical region studied with polymerase chain reaction amplification of di- and tetranucleotide repeats did not indicate any partial trisomy 21. From this study we conclude that the patient does not have any partial submicroscopic trisomy for any segment of chromosome 21. It seems reasonable to assume that she suffers from an autosomal recessive disorder which is phenotypically indistinguishable from DS. © 1996 Wiley-Liss, Inc. 相似文献
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Farber lipogranulomatosis with predominant joint involvement mimicking juvenile idiopathic arthritis
Mikhail M. Kostik Irina A. Chikova Vladislav V. Avramenko Laly I. Vasyakina Emmanuelle Le Trionnaire Vyacheslav G. Chasnyk Thierry Levade 《Journal of inherited metabolic disease》2013,36(6):1079-1080
The case of a 10-year-old boy with Farber lipogranulomatosis with predominant joint involvement, subacute, laryngeal and tongue granulomas, microcytic anemia, elevated ESR and CRP, is presented. The boy had no signs of CNS and internal organ involvement. The disease manifested at 6 months; at 11 months the boy had widespread granulomatous polyarthritis with contractures, and juvenile idiopathic arthritis (JIA) was suggested. All antirheumatic therapies failed. Immunologic assessment revealed elevated serum interleukin-1β, increased T-helper, NK and CD25-positive cells, and circulating immune complexes. Our case with predominant rheumatologic manifestations illustrates a differential diagnosis of JIA. 相似文献