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排序方式: 共有2965条查询结果,搜索用时 15 毫秒
131.
Thomas Wirth MD MSc Louise Laure Mariani MD PhD Gaber Bergant MD Michel Baulac MD PhD Marie-Odile Habert MD Nathalie Drouot MSc Emmanuelle Ollivier MSc Alenka Hodžić PhD Gorazd Rudolf MD Patrick Nitschke MSc Gabrielle Rudolf PhD Jamel Chelly MD PhD Christine Tranchant MD PhD Mathieu Anheim MD PhD Emmanuel Roze MD PhD 《Movement disorders》2020,35(5):880-885
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Duboc H Rainteau D Rajca S Humbert L Farabos D Maubert M Grondin V Jouet P Bouhassira D Seksik P Sokol H Coffin B Sabaté JM 《Neurogastroenterology and motility》2012,24(6):513-20, e246-7
Background Irritable bowel syndrome (IBS) is a multifactorial disease for which a dysbiosis of the gut microbiota has been described. Bile acids (BA) could play a role as they are endogenous laxatives and are metabolized by gut microbiota. We compared fecal BA profiles and microbiota in healthy subjects (HS) and patients with diarrhea‐predominant IBS (IBS‐D), and we searched for an association with symptoms. Methods Clinical features and stool samples were collected in IBS‐D patients and HS. Fecal BA profiles were generated using HPLC coupled to tandem mass spectrometry. The fecal microbiota composition was assessed by q‐PCR targeting dominant bacterial groups and species implicated in BA transformation. Key Results Fourteen IBS‐D patients and 18 HS were included. The two groups were comparable in terms of age and sex. The percentage of fecal primary BA was significantly higher in IBS‐D patients than in HS, and it was significantly correlated with stool consistency and frequency. Fecal counts of all bacteria, lactobacillus, coccoides, leptum and Faecalibacterium prausnitzii were similar. There was a significant increase of Escherichia coli and a significant decrease of leptum and bifidobacterium in IBS‐D patients. Conclusions & Inferences We report an increase of primary BA in the feces of IBS‐D patients compared to HS, correlated with stool consistency and frequency. A dysbiosis of different bacterial groups was detected, some of them involved in BA transformation. As the gut microbiota is the exclusive pathway to transform primary into secondary BA, this suggests a functional consequence of dysbiosis, leading to lower BA transformation. 相似文献
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J L La? J P Jouet J B Savary P Fenaux F Bauters M Deminatti 《Cancer Genetics and Cytogenetics》1987,25(1):103-107
A case of chronic myelogenous leukemia in an elderly man with a new translocation, t(8;11)(q24;q13), associated with a Philadelphia t(9;22) translocation is described. The clinical and hematologic aspects of the disease did not seem to differ from those of the usual cases of chronic myelogenous leukemia except for a basophilic blast crisis. 相似文献
138.
Three cases of translocation (8;16)(p11;p13) observed in acute myelomonocytic leukemia: a new specific subgroup? 总被引:1,自引:0,他引:1
J L La? M Zandecki J P Jouet J B Savary A Lambiliotte F Bauters A Cosson M Deminatti 《Cancer Genetics and Cytogenetics》1987,27(1):101-109
In three cases of acute nonlymphocytic leukemia we observed a translocation (8;16)(p11;p13); in one case it was the sole karyotypic change and in the other two cases it was associated with other structural anomalies. All three cases were nonhyperleukocytic myelomonocytic leukemias with erythrophagocytosis by some blast cells and cytochemistry results consistent with leukemic proliferation of a common monocytic-granulocytic precursor. The importance of this translocation is discussed, and the implication of band 16p13 in myelomonocytic leukemia is stressed. 相似文献
139.
Airborne allergic contact dermatitis caused by isothiazolinones in water‐based paints: a retrospective study of 44 cases
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Emmanuelle Amsler Olivier Aerts Nadia Raison‐Peyron Michèle Debons Brigitte Milpied Fran?oise Giordano‐Labadie Julie Waton Marie C. Ferrier‐Le Bou?dec Isabelle Lartigau Catherine Pecquet Haudrey Assier Martine Avenel‐Audran Claire Bernier Florence Castelain Evelyne Collet Marie‐No?lle Crépy Nathalie Genillier Pascal Girardin Pauline Pralong Florence Tetart Dominique Vital‐Durand Angele Soria Annick Barbaud 《Contact dermatitis》2017,77(3):163-170
140.
Pierre Bordigoni Hélène Esperou Gérard Souillet JosÉ Pico Gérard Michel Brigitte Lacour Josy Reiffers Alain Sadoun Pierre Rohrlich Jean-Pierre Jouet Noël Milpied Patrick Lutz Emmanuel Plouvier Guy Cornu Jean-Pierre Vannier Virginie Gandemer HervÉ Rubie Nicole Gratecos Guy Leverger Jean-Louis Stephan Patrice Boutard & Jean-Paul Vernant 《British journal of haematology》1998,102(3):656-665
We investigated the use of a new conditioning regimen followed by allogeneic bone marrow transplantation (BMT) for treating children with acute lymphoblastic leukaemia (ALL) after relapse within 6 months of the completion of therapy. One hundred and sixteen children with acute lymphoblastic leukaemia in second or subsequent complete remission (CR) underwent allogeneic bone marrow transplantation from HLA-identical siblings after a preparative regimen comprising total body irradiation (TBI), high-dose cytosine arabinoside and melphalan (TAM regimen). The Kaplan-Meier product-limit estimate (mean ± SE) of disease-free survival (DFS) at 7 years was 59.5 ± 9% (95% confidence interval). The estimated chance of relapse was 22.5 ± 15% with a median follow-up of 88.5 months (range 51–132). 26 patients (22.4%) died with no evidence of recurrent leukaemia, mainly from interstitial pneumonitis, veno-occlusive disease or acute graft-versus-host disease (GVHD). Three factors significantly affected DFS: acute GVHD, site of relapse and, for children in second remission after a marrow relapse, the disease status at the time of transplantation. The DFS were 59.02 ± 12.6%, 37.5 ± 19.8% and 77.4 ± 15% among patients in CR2 after a marrow relapse, in CR3 or in untreated partial marrow relapse, and in CR2 after an isolated CNS relapse, respectively. The lowest DFS was seen in children with acute GVHD grades 3–4. Two significant factors were associated with relapse: the marrow status at the time of transplantation and chronic GVHD. The relapse rate was lower among children in CR2 or with chronic GVHD. We conclude that transplantation after the TAM regimen is an effective therapy for this population with acceptable toxicity, particularly for children in second remission after a very early marrow relapse, or those with early isolated CNS involvement. 相似文献