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131.
Thomas Wirth MD MSc Louise Laure Mariani MD PhD Gaber Bergant MD Michel Baulac MD PhD Marie-Odile Habert MD Nathalie Drouot MSc Emmanuelle Ollivier MSc Alenka Hodžić PhD Gorazd Rudolf MD Patrick Nitschke MSc Gabrielle Rudolf PhD Jamel Chelly MD PhD Christine Tranchant MD PhD Mathieu Anheim MD PhD Emmanuel Roze MD PhD 《Movement disorders》2020,35(5):880-885
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J L La? J P Jouet J B Savary P Fenaux F Bauters M Deminatti 《Cancer Genetics and Cytogenetics》1987,25(1):103-107
A case of chronic myelogenous leukemia in an elderly man with a new translocation, t(8;11)(q24;q13), associated with a Philadelphia t(9;22) translocation is described. The clinical and hematologic aspects of the disease did not seem to differ from those of the usual cases of chronic myelogenous leukemia except for a basophilic blast crisis. 相似文献
136.
Three cases of translocation (8;16)(p11;p13) observed in acute myelomonocytic leukemia: a new specific subgroup? 总被引:1,自引:0,他引:1
J L La? M Zandecki J P Jouet J B Savary A Lambiliotte F Bauters A Cosson M Deminatti 《Cancer Genetics and Cytogenetics》1987,27(1):101-109
In three cases of acute nonlymphocytic leukemia we observed a translocation (8;16)(p11;p13); in one case it was the sole karyotypic change and in the other two cases it was associated with other structural anomalies. All three cases were nonhyperleukocytic myelomonocytic leukemias with erythrophagocytosis by some blast cells and cytochemistry results consistent with leukemic proliferation of a common monocytic-granulocytic precursor. The importance of this translocation is discussed, and the implication of band 16p13 in myelomonocytic leukemia is stressed. 相似文献
137.
Airborne allergic contact dermatitis caused by isothiazolinones in water‐based paints: a retrospective study of 44 cases
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Emmanuelle Amsler Olivier Aerts Nadia Raison‐Peyron Michèle Debons Brigitte Milpied Fran?oise Giordano‐Labadie Julie Waton Marie C. Ferrier‐Le Bou?dec Isabelle Lartigau Catherine Pecquet Haudrey Assier Martine Avenel‐Audran Claire Bernier Florence Castelain Evelyne Collet Marie‐No?lle Crépy Nathalie Genillier Pascal Girardin Pauline Pralong Florence Tetart Dominique Vital‐Durand Angele Soria Annick Barbaud 《Contact dermatitis》2017,77(3):163-170
138.
Gomes PB Noronha EC de Melo CT Bezerra JN Neto MA Lino CS Vasconcelos SM Viana GS de Sousa FC 《Journal of ethnopharmacology》2008,120(2):209-214
Ethnopharmacological relevance
Petiveria alliacea L. (tipi) a shrub from Phytolaccaceae family is popularly used in folk medicine for treating a wide variety of disorders in South and Central America.Aim of the study
To investigate the neuropharmacological properties on experimental animals.Materials and methods
The acetate (FA), hexanic (FH), hydroalcoholic (FHA) and precipitated hydroalcoholic (FHAppt) fractions from the root of tipi were studied to investigate its pharmacological properties in the classical behavioral models (open-field, elevated plus maze-EPM, rotarod, barbiturate-induced sleeping time, forced swimming and pentylenetetrazole (PTZ)-induced convulsions tests) using mice. These fractions were administered intraperitoneally and orally to female mice at single doses of 100 and 200 mg/kg.Results
All these fractions decreased the locomotor activity, rearing and grooming in the open-field test, suggesting a possible central depressant action. No significant effect was evident on motor coordination of the animals in the rotarod test. On EPM, all the fractions of tipi presented a significant reduction on the time of permanence in the open arms, indicating an absence of anxiolytic-like effect. In addition, the fractions increased the immobility time in the forced swimming test and potentiated pentobarbital-induced sleeping time in mice, confirmed a probable sedative and central depressant effect. Furthermore, the fractions increased the latency to the first convulsion and the lethal time of the PTZ-induced convulsions test in the animals, confirmed its popular use as anticonvulsant.Conclusion
Our results suggest that the fractions of P. alliacea L. contains biologically active substance(s) that might be acting in the CNS and have significant depressant and anticonvulsant potentials, supporting folk medicine use of this plant. 相似文献139.
Duboc H Rainteau D Rajca S Humbert L Farabos D Maubert M Grondin V Jouet P Bouhassira D Seksik P Sokol H Coffin B Sabaté JM 《Neurogastroenterology and motility》2012,24(6):513-20, e246-7
Background Irritable bowel syndrome (IBS) is a multifactorial disease for which a dysbiosis of the gut microbiota has been described. Bile acids (BA) could play a role as they are endogenous laxatives and are metabolized by gut microbiota. We compared fecal BA profiles and microbiota in healthy subjects (HS) and patients with diarrhea‐predominant IBS (IBS‐D), and we searched for an association with symptoms. Methods Clinical features and stool samples were collected in IBS‐D patients and HS. Fecal BA profiles were generated using HPLC coupled to tandem mass spectrometry. The fecal microbiota composition was assessed by q‐PCR targeting dominant bacterial groups and species implicated in BA transformation. Key Results Fourteen IBS‐D patients and 18 HS were included. The two groups were comparable in terms of age and sex. The percentage of fecal primary BA was significantly higher in IBS‐D patients than in HS, and it was significantly correlated with stool consistency and frequency. Fecal counts of all bacteria, lactobacillus, coccoides, leptum and Faecalibacterium prausnitzii were similar. There was a significant increase of Escherichia coli and a significant decrease of leptum and bifidobacterium in IBS‐D patients. Conclusions & Inferences We report an increase of primary BA in the feces of IBS‐D patients compared to HS, correlated with stool consistency and frequency. A dysbiosis of different bacterial groups was detected, some of them involved in BA transformation. As the gut microbiota is the exclusive pathway to transform primary into secondary BA, this suggests a functional consequence of dysbiosis, leading to lower BA transformation. 相似文献