全文获取类型
收费全文 | 977篇 |
免费 | 50篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 39篇 |
妇产科学 | 20篇 |
基础医学 | 132篇 |
口腔科学 | 61篇 |
临床医学 | 60篇 |
内科学 | 169篇 |
皮肤病学 | 18篇 |
神经病学 | 148篇 |
特种医学 | 30篇 |
外科学 | 105篇 |
综合类 | 10篇 |
预防医学 | 99篇 |
眼科学 | 18篇 |
药学 | 31篇 |
中国医学 | 7篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 9篇 |
2022年 | 18篇 |
2021年 | 27篇 |
2020年 | 18篇 |
2019年 | 44篇 |
2018年 | 35篇 |
2017年 | 24篇 |
2016年 | 16篇 |
2015年 | 21篇 |
2014年 | 40篇 |
2013年 | 41篇 |
2012年 | 66篇 |
2011年 | 59篇 |
2010年 | 39篇 |
2009年 | 24篇 |
2008年 | 52篇 |
2007年 | 79篇 |
2006年 | 41篇 |
2005年 | 51篇 |
2004年 | 54篇 |
2003年 | 34篇 |
2002年 | 27篇 |
2001年 | 22篇 |
2000年 | 6篇 |
1999年 | 16篇 |
1997年 | 8篇 |
1995年 | 5篇 |
1993年 | 5篇 |
1992年 | 6篇 |
1991年 | 12篇 |
1990年 | 5篇 |
1989年 | 10篇 |
1988年 | 6篇 |
1986年 | 3篇 |
1985年 | 12篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 8篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 3篇 |
1974年 | 7篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1970年 | 5篇 |
1969年 | 3篇 |
1919年 | 5篇 |
排序方式: 共有1029条查询结果,搜索用时 15 毫秒
81.
82.
D.J.F. Rosa R.F. Machado F.A.T. Matias S.D. Cedrim F.L. Noronha D. Gaburri A. Gamonal 《Journal of the European Academy of Dermatology and Venereology》2012,26(3):348-353
Introduction Psoriasis is a disease with proinflammatory state that has been associated with an increased risk of cardiovascular disease. Method This is a cross‐sectional, observational study, with analysis of 98 patients being treated for psoriasis. Several variables were analysed: gender, age, weight, height, Psoriasis Area and Severity Index (PASI), blood pressure, blood glucose, blood lipids, obesity, metabolic syndrome (MS) and Framingham score. Results Ninety‐eight patients were analysed (51 men; 52.0%). Age ranged from 12 years to 98 years. About 67% of the patients had dyslipidaemia, 14.3% had type 2 diabetes mellitus and 59.2% had systemic arterial hypertension. Forty‐four percentage of patients had the MS and 27.6% had a body mass index >30 kg/m2. The Psoriasis Area and Severiy Index were equal or over 10 in 27 patients, 18 of whom had dyslipidaemia (P = 0.929) and 14 of whom had the MS (P = 0.327). Seventy‐four patients were over the age of 40 years and, of these, 56 had dyslipidaemia (P = 0.002) and 41 had the MS (P < 0.001). For 89 patients, whose cardiovascular risk was calculated according to the Framingham criteria, 71.4% at high or moderate risk had a PASI below 10 (P = 0.945) and 100% at high or moderate risk were over the age of 40 years (P = 0.001). Conclusion There was strong evidence that psoriasis patients have an increased cardiovascular risk, chiefly those over the age of 40 years, probably because of the chronic inflammatory state. It seems that the severity of the cutaneous manifestations was not associated with a higher risk in these patients. 相似文献
83.
Evaluation of mast cells in periapical cysts, dentigerous cysts, and keratocystic odontogenic tumors
de Noronha Santos Netto J Pires FR da Fonseca EC Silva LE de Queiroz Chaves Louren?o S 《Journal of oral pathology & medicine》2012,41(8):630-636
J Oral Pathol Med (2012) 41 : 630–636 Background: Several cell types are associated with the development of cystic and tumoral odontogenic lesions. Among inflammatory cells, mast cells can be associated with their pathogenesis. The aim of this study was to analyze mast cells in periapical cysts, dentigerous cysts, and keratocystic odontogenic tumors. Methods: Tissue sections were submitted to toluidine blue staining and immunohistochemistry with antibody anti‐tryptase (clone G3). Mast cells were quantitated using Image‐Pro Plus software to obtain the mean number of mast cells in three regions: epithelial, superficial portion of the fibrous wall and deep portion of the fibrous wall from 20 periapical cysts, 20 dentigerous cysts (six non‐inflamed and 14 inflamed) and 20 keratocystic odontogenic tumors (four non‐inflamed and 16 inflamed). Results: The mean number of mast cells detected per lesion by immunohistochemistry (4.1) was higher than by histochemistry (1.5) (P < 0.0001). Inflamed dentigerous cysts and keratocystic odontogenic tumors showed a higher mean number of mast cells than non‐inflamed lesions in all regions. The deep region from all cysts showed the highest mean number of degranulated mast cells, except for non‐inflamed keratocystic odontogenic tumors analyzed by immunohistochemistry. Conclusions: Immunohistochemical staining detected higher number of mast cells than histochemistry. The higher number of mast cells observed in inflamed lesions could indicate the participation of these cells in the inflammatory response in odontogenic lesions. The prevalence of degranulated mast cells in the deep region suggests intense activity of these cells, possibly related to growth of cystic lesions. 相似文献
84.
F.V. Mariano A.L.F. Noronha R.O. Gondak A.M. de A.M. Altemani O.P. de Almeida L.P. Kowalski 《International journal of oral and maxillofacial surgery》2013,42(6):685-692
Carcinoma ex pleomorphic adenoma (CXPA) is a rare tumour, with different prevalence rates reported among studies. Epidemiological studies of large series of CXPAs in developing countries are scarce. The aim of the present study was to describe Brazilian patients with CXPA; this was a retrospective study of 38 patients. Demographic and clinico-pathological features were evaluated. No preferential gender was found, and the mean age at diagnosis was 57.6 years. The most commonly involved site was the parotid, followed by the submandibular and the minor salivary glands. A prevalence of clinical stages III and IV was observed at diagnosis. The most common histological subtypes were salivary duct carcinoma, adenocarcinoma not otherwise specified, myoepithelial carcinoma, and epithelial–myoepithelial carcinoma. Moreover, by invasive phase, most were frankly invasive carcinoma. Recurrence was observed in seven out of 24 patients with outcome information available, and all were invasive cases. All seven patients died of causes related to the disease. The distributions of cases according to age, gender, tumour location, and clinical stage were similar to those reported in the literature. Frankly invasive cases presented a worse prognosis. More information is needed to further our understanding of the clinico-pathological aspects of CXPA. 相似文献
85.
A 24-year-old woman with non-pituitary dependent Cushing's syndrome was found to have bilateral adrenal myelolipomas at surgery. These benign tumors consist of bone marrow and fat and are uncommon incidental findings that are discovered by computed tomography. Myelolipomas have rarely been associated with Cushing's syndrome, but the cause of the syndrome has not always been defined, because the reports preceded modern diagnostic methods. Careful examination of the adrenal glands from our patient showed a fusion of myelolipoma elements and adrenal cells without distinct adenomas or the typical nodular pattern of adrenal hyperplasia. This report suggests that adrenal myelolipomas and atypical hyperplasia of the zona fasciculata may be anatomically and functionally related. 相似文献
86.
G.R. Iball D. Tolan G.R. Avery L.H. Cope T. Hoare H. Lambie A. Lowe R.J. de Noronha C.L. Roberts M.E. Wilkinson P. Woolfall 《Clinical radiology》2021,76(8):626.e13-626.e21
87.
Vijay M. Patil MBBS MD DM Vanita Noronha MBBS MD DM Amit Joshi MBBS MD DM Anant Ramaswamy MBBS MD DM Sachin Dhumal BHMS Shashikant Juvekar MBBS MD Supreeta Arya MBBS MD Abhishek Mahajan MBBS MD Pankaj Chaturvedi MBBS MS Anil D'Cruz MBBS MS Atanu Bhattacharjee PhD Kumar Prabhash MBBS MD DM 《Head & neck》2017,39(5):886-892
88.
89.
Andréa Noronha Pessoa de Queiroz Paulo F Collett-Solberg Monique Esteves Cardoso Rafaela Cattan Jusan Mario Vaisman Marília Martins Guimar?es 《Growth hormone & IGF research》2007,17(3):254-260
OBJECTIVES: The pathophysiology of the short stature in girls with Turner syndrome (TS) is not well understood. The "IGF-I generation test" is used to assess the sensitivity to growth hormone. We compared the biochemical response to four days of growth hormone of TS and controls. STUDY DESIGN: Pre-pubertal TS were recruited to participate in the study. Their siblings served as controls. IGF-I, IGFBP-3 and ALS were measured before and 5 days after using hGH (0.05mg/kg/day). Student-t test was used to compare the differences in their responses. RESULTS: Eleven TS (mean age of 8.5+/-2.4) and 11 siblings (6 females and 5 males) (mean age of 7.0+/-2.0) participated in the study. The basal serum levels of IGF-I, IGFBP-3 and ALS were normal and not different between groups (p=0.62 for IGF-I, p=0.91 for IGFBP-3 and p=0.51 for ALS). The IGF-I generation test was positive in all controls and in 10/11 TS. The IGFBP-3 generation test was positive in 6/11 controls and 4/11 TS. After hGH the mean IGFBP-3 was lower in TS than in controls (p=0.08). The ALS response to hGH was not uniform between groups. CONCLUSIONS: The IGF-I and ALS generation test results were not different between controls and TS. The IGFBP-3 results were higher in the control group but more than 50% of tested children did not pass. The IGF-I/IGFBP-3 generation tests, as presently done, did not help in the understanding of the short stature in TS. The use of different GH dosages and number of doses need to be investigated. 相似文献
90.
Fabiana Pinheiro da Silva Géssica Maria Moreira Kamilla Zomkowski Marcos Amaral de Noronha Fabiana Flores Sperandio 《Journal of manipulative and physiological therapeutics》2019,42(7):503-513
ObjectiveThe purpose of this systematic review was to investigate the effectiveness of manual therapy (MT) for chronic musculoskeletal pain (CMP) in the upper limbs and thorax of female breast cancer survivors and to investigate the changes in the quality of life and function of these patients.MethodsSystematic searches were performed in the databases MEDLINE/PubMed, Cumulative Index of Nursing and Allied Health/EBSCO, Web of Science, and Physiotherapy Evidence Database, through March 2018, to identify randomized controlled trials investigating whether MT was effective to treat CMP pain in female breast cancer survivors (PROSPERO number CDR42017074175).ResultsThe database searches retrieved 1562 titles, and after screening, 5 papers were included for full analysis. The manual therapy techniques described in the included studies involved myofascial induction, myofascial release, classic massage, ischemic compression of trigger points, and myofascial therapy. A meta-analysis, using a fixed-effects model, found that MT decreased CMP intensity (standardized mean difference: 0.32; 95% CI 0.06-0.57), but no significant difference was observed in quality of life after the MT intervention in comparison with a control condition (standardized mean difference: 0.14; 95% CI 0.17-0.46).ConclusionCurrent evidence suggests that MT is considered effective for treating CMP in the upper limbs and thorax of female breast cancer survivors. 相似文献