全文获取类型
收费全文 | 1196篇 |
免费 | 76篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 26篇 |
妇产科学 | 17篇 |
基础医学 | 164篇 |
口腔科学 | 19篇 |
临床医学 | 224篇 |
内科学 | 166篇 |
皮肤病学 | 11篇 |
神经病学 | 79篇 |
特种医学 | 29篇 |
外科学 | 104篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 158篇 |
眼科学 | 9篇 |
药学 | 101篇 |
中国医学 | 2篇 |
肿瘤学 | 153篇 |
出版年
2024年 | 4篇 |
2023年 | 14篇 |
2022年 | 32篇 |
2021年 | 49篇 |
2020年 | 35篇 |
2019年 | 49篇 |
2018年 | 37篇 |
2017年 | 30篇 |
2016年 | 33篇 |
2015年 | 27篇 |
2014年 | 51篇 |
2013年 | 70篇 |
2012年 | 91篇 |
2011年 | 90篇 |
2010年 | 52篇 |
2009年 | 61篇 |
2008年 | 74篇 |
2007年 | 74篇 |
2006年 | 65篇 |
2005年 | 58篇 |
2004年 | 45篇 |
2003年 | 31篇 |
2002年 | 31篇 |
2001年 | 11篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1990年 | 9篇 |
1989年 | 10篇 |
1988年 | 7篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1985年 | 15篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1971年 | 2篇 |
排序方式: 共有1272条查询结果,搜索用时 13 毫秒
31.
32.
33.
Elin Nilsson Constantin Bodolea Torsten Gordh Anders Larsson 《Neurological sciences》2013,34(4):445-448
Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893–17,636 pg/mL for cathepsin B and 2,681–11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (r s = 0.38, p = 0.00002) and cathepsin S (r s = 0.35, p = 0.0001) in CSF. 相似文献
34.
Margaret L. Crivello MD Karen Ruth MS Elin R. Sigurdson MD PhD Brian L. Egleston PhD Kathryn Evers MD Yu-Ning Wong MD Marcia Boraas MD Richard J. Bleicher MD 《Annals of surgical oncology》2013,20(1):102-110
Background
Guidelines for breast cancer staging exist, but adherence remains unknown. This study evaluates patterns of imaging in early stage breast cancer usually reserved for advanced disease.Methods
Surveillance Epidemiology, and End Results data linked to Medicare claims from 1992–2005 were reviewed for stage I/II breast cancer patients. Claims were searched for preoperative performance of computed tomography (CT), positron emission tomography (PET), bone scans, and brain magnetic resonance imaging (MRI) (“advanced imaging”).Results
There were 67,874 stage I/II breast cancer patients; 18.8 % (n = 12,740) had preoperative advanced imaging. The proportion of patients having CT scans, PET scans, and brain MRI increased from 5.7 % to 12.4 % (P < 0.0001), 0.8 % to 3.4 % (P < 0.0001) and 0.2 % to 1.1 % (P = 0.008), respectively, from 1992 to 2005. Bone scans declined from 20.1 % to 10.7 % (P < 0.0001). “Breast cancer” (174.x) was the only diagnosis code associated with 62.1 % of PET scans, 37.7 % of bone scans, 24.2 % of CT, and 5.1 % of brain MRI. One or more symptoms or metastatic site was suggested for 19.6 % of bone scans, 13.0 % of CT, 13.0 % of PET, and 6.2 % of brain MRI. Factors associated (P < 0.05) with use of all modalities were urban setting, breast MRI and ultrasound. Breast MRI was the strongest predictor (P < 0.0001) of bone scan (odds ratio [OR] 1.63, 95 % confidence interval [CI] 1.44–1.86), Brain MRI (OR 1.74, 95 % CI 1.15–2.63), CT (OR 2.42, 95 % CI 2.12–2.76), and PET (OR 5.71, 95 % CI 4.52–7.22).Conclusions
Aside from bone scans, performance of advanced imaging is increasing in early stage Medicare breast cancer patients, with limited rationale provided by coded diagnoses. In light of existing guidelines and increasing scrutiny about health care costs, greater reinforcement of current indications is warranted. 相似文献35.
Elin M. Svensson Mats O. Karlsson 《Journal of pharmacokinetics and pharmacodynamics》2014,41(2):153-158
The objective of this work was to facilitate the development of nonlinear mixed effects models by establishing a diagnostic method for evaluation of stochastic model components. The random effects investigated were between subject, between occasion and residual variability. The method was based on a first-order conditional estimates linear approximation and evaluated on three real datasets with previously developed population pharmacokinetic models. The results were assessed based on the agreement in difference in objective function value between a basic model and extended models for the standard nonlinear and linearized approach respectively. The linearization was found to accurately identify significant extensions of the model’s stochastic components with notably decreased runtimes as compared to the standard nonlinear analysis. The observed gain in runtimes varied between four to more than 50-fold and the largest gains were seen for models with originally long runtimes. This method may be especially useful as a screening tool to detect correlations between random effects since it substantially quickens the estimation of large variance–covariance blocks. To expedite the application of this diagnostic tool, the linearization procedure has been automated and implemented in the software package PsN. 相似文献
36.
Eli Natvik Karen Synne Groven Målfrid Råheim Eva Gjengedal Shaun Gallagher 《Physiotherapy theory and practice》2019,35(2):101-108
Physiotherapists are well placed to help people adjust and engage meaningfully with the world following major weight loss. Recent research indicates that the body size a patient has lived with for years can continue to affect movement and perception even after largescale weight loss. This article explores this discrepancy in depth from the perspective of phenomenology and space perception and through the concepts of body image, body schema, and affordances. It draws on an empirical example in which a nautical engineer described his lived experience of returning to work following bariatric surgery and the discrepancies he experienced while adjusting to his new situation, particularly when moving his smaller body around the ship’s engine room, previously inaccessible to him. Analysis of this empirical example suggests that transitions in weight and size following bariatric surgery are both highly explicit in awareness (i.e., body image) and outside awareness (i.e., body schema). Major weight loss can open up new affordances and possibilities of being in the world, but only after adjustments in body image and body schema. The article suggests ways in which such insights can contribute to physiotherapists’ clinical development and practice when working with patients undergoing major weight loss. 相似文献
37.
38.
Sarah Keildson Joao Fadista Claes Ladenvall ?sa K. Hedman Targ Elgzyri Kerrin S. Small Elin Grundberg Alexandra C. Nica Daniel Glass J. Brent Richards Amy Barrett James Nisbet Hou-Feng Zheng Tina R?nn Kristoffer Str?m Karl-Fredrik Eriksson Inga Prokopenko MAGIC Consortium DIAGRAM Consortium MuTHER Consortium Timothy D. Spector Emmanouil T. Dermitzakis Panos Deloukas Mark I. McCarthy Johan Rung Leif Groop Paul W. Franks Cecilia M. Lindgren Ola Hansson 《Diabetes》2014,63(3):1154-1165
Using an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression quantitative trait loci [eQTLs]) as well as expression associated with measures of insulin sensitivity. We investigated associations of 3,799,401 genetic variants in expression of >7,000 genes from three cohorts (n = 104). We identified 287 genes with cis-acting eQTLs (false discovery rate [FDR] <5%; P < 1.96 × 10−5) and 49 expression–insulin sensitivity phenotype associations (i.e., fasting insulin, homeostasis model assessment–insulin resistance, and BMI) (FDR <5%; P = 1.34 × 10−4). One of these associations, fasting insulin/phosphofructokinase (PFKM), overlaps with an eQTL. Furthermore, the expression of PFKM, a rate-limiting enzyme in glycolysis, was nominally associated with glucose uptake in skeletal muscle (P = 0.026; n = 42) and overexpressed (Bonferroni-corrected P = 0.03) in skeletal muscle of patients with T2D (n = 102) compared with normoglycemic controls (n = 87). The PFKM eQTL (rs4547172; P = 7.69 × 10−6) was nominally associated with glucose uptake, glucose oxidation rate, intramuscular triglyceride content, and metabolic flexibility (P = 0.016–0.048; n = 178). We explored eQTL results using published data from genome-wide association studies (DIAGRAM and MAGIC), and a proxy for the PFKM eQTL (rs11168327; r2 = 0.75) was nominally associated with T2D (DIAGRAM P = 2.7 × 10−3). Taken together, our analysis highlights PFKM as a potential regulator of skeletal muscle insulin sensitivity. 相似文献
39.
Longitudinal Association Between Physical Activity and Frailty Among Community-Dwelling Older Adults
Xuxi Zhang MPH Siok Swan Tan PhD Carmen Betsy Franse PhD Lovorka Bilajac PhD Tamara Alhambra-Borrás PhD Jorge Garcés-Ferrer PhD Arpana Verma MD PhD Greg Williams MSc Gary Clough PGCert Elin Koppelaar PhD Tasos Rentoumis MSc Rob van Staveren MSc Antonius J. J. Voorham PhD Francesco Mattace-Raso MD PhD Amy van Grieken PhD Hein Raat MD PhD 《Journal of the American Geriatrics Society》2020,68(7):1484-1493