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排序方式: 共有10000条查询结果,搜索用时 343 毫秒
991.
Thomas Wlfel Aline Van Pel Vincent Brichard Jrg Schneider Barbara Seliger Karl-Hermann Meyer Zum Büschenfelde Thierry Boon 《European journal of immunology》1994,24(3):759-764
A number of cytolytic T lymphocyte (CTL) clones derived from several melanoma patients have been found to recognize a majority of melanomas from HLA-A2 patients. We have reported previously that two such CTL clones recognize a product of the tyrosinase gene that is presented by HLA-A2. Here we show that one of these CTL clones recognizes a peptide encoded by the first nine amino acids of the putative signal sequence of tyrosinase. The other CTL clone recognizes a different tyrosinase peptide corresponding to amino acids 368–376. Both peptides contain consensus motifs of HLA-A2 binding peptides. 相似文献
992.
Albano C.; Smitz J.; Camus M.; Riethmuller-Winzen H.; Siebert-Weigel M.; Diedrich K.; Van Steirteghem A.C.; Devroey P. 《Human reproduction (Oxford, England)》1996,11(10):2114-2118
A third-generation gonadotrophin-releasing hormone antagonist(Cetrorelix) was used during ovarian stimulation in 32 patientsundergoing assisted reproduction, in order to prevent the prematureluteinizing hormone (LH) surge. In all patients, ovarian stimulationwas carried out with two or three ampoules of human menopausalgonadotrophin (HMG), starting on day 2 of the menstrual cycle.In addition, 0.5 mg of Cetrorelix was administered daily fromday 6 of HMG treatment until the day of ovulation inductionby human chorionic gonadotrophin (HCG). A significant drop inplasma LH concentration was observed within a few hours of thefirst administration of Cetrorelix (P<0.005). Moreover, noLH surge was detected at any point in the treatment period inany of the 32 patients. A mean oestradiol concentration of 2122±935ng/1 was observed on the day of the HCG administration, indicatingnormal folliculogenesis. Like LH, progesterone concentrationalso dropped within a few hours of the first administrationof Cetrorelix (P< 0.005). A 0.5 mg daily dose of Cetrorelixprevented a premature LH surge in all the 32 patients treated. 相似文献
993.
D. Ursi J. P. Ursi M. Ieven M. Docx P. Van Reempts S. R. Pattyn 《Archives of disease in childhood. Fetal and neonatal edition》1995,72(2):F118-F120
A case of probable vertical transmission of Mycoplasma pneumoniae is presented. The presence of M pneumoniae was demonstrated by the polymerase chain reaction (PCR) in the nasopharyngeal aspirate of a newborn who developed pneumonia shortly after birth. This result was confirmed by performing a second PCR, amplifying another part of the genome of M pneumoniae. It is concluded that M pneumoniae can be added to the long list of pathogens known to cause congenital pneumonia. 相似文献
994.
K. Van Der Torren G. Groeneweg G. Van Lith 《Documenta ophthalmologica. Advances in ophthalmology》1988,69(2):153-159
Studying the oscillatory potentials in diabetic retinopathy, the authors experienced several problems interpreting results of digital filtering. The main problem was the separation of the first potential from the a-wave, since their frequencies are within the same range. To improve the procedure of measuring implicit times and of calculating amplitudes, the filtering was started with a finite impulse response filter and followed by a fast Fourier transform. The power of the oscillatory potential was calculated by determining the dominant frequency in the Fourier transformed response and expressed in microwatts. A group of normal subjects was compared with a group of early diabetic retinopathy patients. It appears that even in pathological circumstances a quantitative expression of the oscillatory potential is possible. 相似文献
995.
996.
997.
998.
Background
The efficacy of academic detailing in changing physicians' knowledge and practice has been the subject of many primary research publications and systematic reviews. However, there is little written about the features of academic detailing that physicians find valuable or that affect their use of it. The goal of our project was to explore family physicians' (FPs) perceptions of academic detailing and the factors that affect their use of it. 相似文献999.
Barbara Resnick Denise Orwig Janet Yu-Yahiro William Hawkes Michelle Shardell J. Richard Hebel Sheryl Zimmerman Justine Golden Michele Werner Jay Magaziner 《Annals of behavioral medicine》2007,34(1):67-76
Background: Exercise is an important strategy with potential to improve recovery in older adults following a hip fracture.Purpose: The purpose of this study was to test the impact of a self-efficacy based intervention, the Exercise Plus Program, and the
different components of the intervention, on self-efficacy, outcome expectations, and exercise behavior among older women
post-hip fracture.Methods: Participants were randomized to one of four groups: exercise plus, exercise only, plus only (i.e., motivation), or routine
care. Data collection was done at baseline (within 22 days of fracture), 2, 6, and 12 months post-hip fracture.Results: A total of 209 women were recruited with an average age of 81.0 years (SD=6.9). The majority was White (97.1%), was widowed
(57.2%), and had a high school education (66.7%). Generalized Estimating Equations were used to perform repeated measures
analyses. No differences in trajectories of recovery were observed for self-efficacy or outcome expectations. A statistically
significant difference in the overall trajectory of time in exercise was seen (p<.001), with more time spent exercising in
all three treatment groups.Conclusions: The study demonstrated that it was possible to engage these women in a home-based exercise program and that the plus only,
exercise only, and the exercise plus groups all increased exercise.
Support for this project was provided by National Institute on Aging grants R37 AG09901, R01-AG18668, R01 AG17082, and the
Claude D. Pepper Older Americans Independence Center P60-AG12583. 相似文献
1000.
Timothy R. McAdams Karl R. Knudsen Naveen Yalamanchi James Chang Stuart B. Goodman 《Knee surgery, sports traumatology, arthroscopy》2007,15(9):1144-1149
The purpose of this study was to compare the histological characteristics of an autogenous fascia lata graft alone and a fascia
lata graft combined with a deltoid flap in the reconstruction of rotator cuff tears. Ten New Zealand white rabbits were divided
into two groups. Infraspinatus tendon defects (1 × 1 cm) were created in each animal. Reconstruction consisted of either a
fascia lata graft alone or a fascia lata graft combined with a distally based deltoid flap. At 3 months, tissue harvest and
histological analysis was performed. Compared to the fascia lata graft alone, there was significantly increased remodeling
activity and neovascularization in the group that included a deltoid flap. Also, there was pronounced interdigitation at the
graft/flap interface in the latter group. A mutually beneficial relationship may exist when an autogenous fascial graft is
combined with a functional deltoid flap for reconstructing large rotator cuff defects. 相似文献