全文获取类型
收费全文 | 167篇 |
免费 | 6篇 |
国内免费 | 3篇 |
专业分类
儿科学 | 12篇 |
基础医学 | 17篇 |
口腔科学 | 4篇 |
临床医学 | 9篇 |
内科学 | 45篇 |
皮肤病学 | 8篇 |
神经病学 | 9篇 |
特种医学 | 26篇 |
外科学 | 8篇 |
综合类 | 5篇 |
预防医学 | 10篇 |
药学 | 13篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 1篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 4篇 |
2013年 | 7篇 |
2012年 | 2篇 |
2011年 | 1篇 |
2010年 | 4篇 |
2009年 | 10篇 |
2008年 | 4篇 |
2007年 | 9篇 |
2006年 | 3篇 |
2005年 | 5篇 |
2004年 | 2篇 |
2003年 | 3篇 |
2002年 | 6篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 9篇 |
1997年 | 11篇 |
1996年 | 5篇 |
1995年 | 11篇 |
1994年 | 5篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有176条查询结果,搜索用时 687 毫秒
61.
Gabie KB. Ong Ben Tsai Roger Lozano Patron Olaf Johansen Frederick Lane R. Barry Melbert Tobi Reidy Dipen Maun 《American journal of surgery》2021,221(3):566-569
BackgroundThis study compared transanal total mesorectal excision (taTME) to laparoscopic total mesorectal excision (laTME) for the treatment of low rectal cancer. Adequacy of oncologic resection as well as postoperative outcomes were analyzed.MethodsWe retrospectively reviewed all proctectomy for low rectal cancer by a single surgeon at our institution from January 2014 to September 2019.ResultsThere were 20 taTME and 30 laTME patients. TaTME patients had more distal tumors with no difference in pathologic resection margins or frequency of positive distal margin. Operative times were longer for taTME, but there were no differences in short-term outcomes or complications. TaTME patients had a higher rate of postoperative fecal incontinence.ConclusionTaTME may be a good option for the most distal tumors, when distal margins may be compromised. TaTME provides equivalent oncologic resection, but there is a higher incidence of postoperative fecal incontinence. 相似文献
62.
63.
Kantarjian HM; Barlogie B; Pershouse M; Swartzendruber D; Keating MJ; McCredie KB; Freireich EJ 《Blood》1985,66(1):39-46
In an effort to develop a new tumor marker suitable for flow cytometric analysis, we examined the value of double-stranded ribonucleic acid (ds- RNA) measurements using propidium iodide after DN'ase treatment. Cellular ds-RNA content was evaluated both in experimental cell lines and in clinical specimens. Higher levels of ds-RNA were present in tumor cells as compared with normal cells. In tumor cells, fluorescence was intensely localized in the nucleolus and was more diffuse in the cytoplasm. Change of less than 10% in the ds-RNA levels was observed in cell lines as a function of cytokinetic determinants such as cycle phase, culture age, and cycle traverse rate. Tumor differentiation by dimethylsulfoxide resulted in a significant decrease in cellular ds-RNA content. For quantitative comparison of clinical material, a ds-RNA excess was defined in relationship to normal peripheral blood lymphocytes. ds-RNA excess greater than 30% was observed in only one of 34 normal tissues (3%) as compared with 124 of 201 neoplastic tissue samples (62%). This incidence was higher in patients with acute leukemia (76%), high-grade and intermediate-grade lymphoma (75%), and high tumor stage myeloma (83%), as compared with chronic leukemia (20%), low-grade lymphoma (25%), and intermediate or low tumor mass myeloma (43%). Prognostically, a high pretreatment ds-RNA excess in myeloma was associated with a lower remission rate. The persistence of ds-RNA excess in the bone marrow of patients with acute myelogenous leukemia in remission predicted for a shorter remission duration (seven v 22 months; P = .05). We conclude that ds-RNA excess, as readily measured objectively and quantitatively by flow cytometry, may have important diagnostic and prognostic implications for the management of patients with malignant disease. 相似文献
64.
65.
Deborah KB Runyoro Mecky IN Matee Olipa D Ngassapa Cosam C Joseph Zakaria H Mbwambo 《BMC complementary and alternative medicine》2006,6(1):11-10
Background
Candida albicans has become resistant to the already limited, toxic and expensive anti-Candida agents available in the market. These factors necessitate the search for new anti-fungal agents. 相似文献66.
Linkage analysis of candidate regions for coeliac disease genes 总被引:5,自引:0,他引:5
Houlston RS; Tomlinson IP; Ford D; Seal S; Marossy AM; Ferguson A; Holmes GK; Hosie KB; Howdle PD; Jewell DP; Godkin A; Kerr GD; Kumar P; Logan RF; Love AH; Johnston S; Marsh MN; Mitton S; O'Donoghue D; Roberts A; Walker-Smith JA; Stratton MF 《Human molecular genetics》1997,6(8):1335-1339
A strong HLA association is seen in coeliac disease [specifically to the
DQ(alpha1*0501,beta1*0201 heterodimer], but this cannot entirely account
for the increased risk seen in relatives of affected cases. One or more
genes at HLA-unlinked loci also predispose to coeliac disease and are
probably stronger determinants of disease susceptibility than HLA. A recent
study has proposed a number of candidate regions on chromosomes 6p23
(distinct from HLA), 6p12, 3q27, 5q33.3, 7q31.3, 11p11, 15q26, 19p13.3,
19q13.1, 19q13.4 and 22cen for the location of a non-HLA linked
susceptibility gene. We have examined these regions in 28 coeliac disease
families by linkage analysis. There was excess sharing of chromosome 6p
markers, but no support for a predisposition locus telomeric to HLA. No
significant evidence in favour of linkage to coeliac disease was obtained
for chromosomes 3q27, 5q33.3, 7q31.3, 11p11, 19p13.3, 19q13.1, 19q13.4 or
22cen. There was, however, excess sharing close to D15S642. The maximum
non-parametric linkage score was 1.99 (P = 0.03). Although the evidence for
linkage of coeliac disease to chromosome 15q26 is not strong, the well
established association between coeliac disease and insulin dependent
diabetes mellitus, together with the mapping of an IDDM susceptibility
locus (IDDM3) to chromosome 15q26, provide indirect support for this as a
candidate locus conferring susceptibility to coeliac disease in some
families.
相似文献
67.
The prevalence of obesity is increasing in America, but its impact on morbidity relative to other health risks is unclear. This paper compares the effects of overweight, poverty, smoking and problem drinking on occurrence of chronic conditions and health-related quality of life. The data were collected from a nationally representative household telephone survey of 9585 adults fielded in 1998, using self-reported measures of height and weight, poverty, smoking status, problem drinking, chronic conditions and SF-12 global scales. Regression analyses were used to estimate effects of health risk factors on morbidity. Thirty-six percent of adults are overweight but not obese (25< or =BMI<30) and another 23% are obese (BMI> or =30). Controlling for demographics, obesity is associated with more chronic conditions and worse physical health-related quality of life (P<0.01). Smoking history and poverty predict having chronic conditions, but their effect sizes are significantly smaller. Even after controlling for chronic conditions, obesity predicts physical health-related quality of life, in that case with an effect size similar to poverty. The effect of problem drinking is always smaller. Obesity is highly prevalent and associated with at least as much morbidity as are poverty, smoking and problem drinking. Nevertheless, the latter have achieved more consistent attention in recent decades in clinical practice and public health policy. 相似文献
68.
KB Nyuar Y Min K Ghebremeskel AKH Khalil MI Elbashir MA Cawford 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(12):1824-1827
Aim: The suckling neonates and infants are reliant primarily on the mother for optimal supply of docosahexaenoic acid (DHA). The richest source of preformed DHA is cold‐water oily fish. Although there is paucity of data, existing evidence suggest women with restricted access to these foods have low or marginal DHA status. The aim of the study was to investigate milk fatty acids of Sudanese mothers whose traditional diet is high in carbohydrate and low in fat and gain some insight into the provision of DHA to the suckling offspring. Methods: Colostrum (n = 26), transitional (n = 20) and mature (n = 14) milk samples were obtained from Northern Sudanese women (NSW) recruited prior to delivery from Ibrahim Malik and Khartoum Teaching Hospitals. Results: The arachidonic acid content of the colostrum (0.87 ± 0.28%) and transitional (0.89 ± 0.29%) and mature (0.48 ± 0.12%) milk of the NSW were broadly comparable with published international values. In contrast, the DHA level (colostrum 0.13 ± 0.07%, transitional 0.13 ± 0.06% and mature milk 0.06 ± 0.05%) was very low. Conclusion: The study reveals breast milk of NSW, whose traditional diet is almost devoid of fish and fish products, is unlikely to provide sufficient DHA to support optimal postnatal neuro‐visual development. 相似文献
69.
A Basit S Nair KB Chakraborthy BB Darshan A Kamath 《The Australasian medical journal》2012,5(3):163-167
Background
Despite her apparent economic success, India is plagued by a high burden of under-nutrition among children under five. This study was aimed at understanding some of the risk factors for under-nutrition in a region with favourable maternal and child health indicators.Method
A case control study was carried out among children aged one to five years attending the paediatric outpatient department in six rural health care centres in Udupi taluk of Karnataka in Southern India. A total of 162 children were included in the study, of which 56 were cases. A semi-structured questionnaire was used to interview the caregivers of the children and the nutritional status was graded according to the Indian Academy of Paediatrics (IAP) grading of protein-energy malnutrition.Results
Under-nutrition was associated with illness in the last one month [OR– 4.78 (CI: 1.83 –12.45)], feeding diluted milk [OR–14.26 (CI: 4.65 – 43.68)] and having more than two children with a birth interval ≤2 years [OR– 4.93 (CI: 1.78 – 13.61)]. Lack of exclusive breast feeding, level of education of the caregiver and environmental factors like source of water did not have an association.Conclusion
Childhood illness, short birth interval and consumption of diluted milk were some of the significant contributory factors noted among this population. Information, Education, Communication (IEC) campaigns alleviating food fads and promoting birth spacing is needed. 相似文献70.