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51.
Howard Mary Beth Jarvis Lenore R. Badolato Gia M. Parrish Benjamin T. Donnelly Katie A. 《Maternal and child health journal》2022,26(5):1059-1066
Maternal and Child Health Journal - Sleep-related infant deaths in the District of Columbia (DC) varies, with rates in certain geographical areas three times higher than DC and seven times higher... 相似文献
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Hickey Gráinne McGilloway Sinead Leckey Yvonne Stokes Ann Bywater Tracey Donnelly Michael 《Prevention science》2021,22(1):113-129
Prevention Science - The adoption and effective delivery of evidence-based interventions within “real-world” community-based, primary health care service settings are of crucial... 相似文献
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Marysol Luna Jason D Guss Laura S Vasquez-Bolanos Macy Castaneda Manuela Vargas Rojas Jasmin M Strong Denise A Alabi Sophie D Dornevil Jacob C Nixon Erik A Taylor Eve Donnelly Xueyan Fu M Kyla Shea Sarah L Booth Rodrigo Bicalho Christopher J Hernandez 《Journal of bone and mineral research》2021,36(9):1823-1834
Modifications to the constituents of the gut microbiome influence bone density and tissue-level strength, but the specific microbial components that influence tissue-level strength in bone are not known. Here, we selectively modify constituents of the gut microbiota using narrow-spectrum antibiotics to identify components of the microbiome associated with changes in bone mechanical and material properties. Male C57BL/6J mice (4 weeks) were divided into seven groups (n = 7–10/group) and had taxa within the gut microbiome removed through dosing with: (i) ampicillin; (ii) neomycin; (iii) vancomycin; (iv) metronidazole; (v) a cocktail of all four antibiotics together (with zero-calorie sweetener to ensure intake); (vi) zero-calorie sweetener only; or (vii) no additive (untreated) for 12 weeks. Individual antibiotics remove only some taxa from the gut, while the cocktail of all four removes almost all microbes. After accounting for differences in geometry, whole bone strength was reduced in animals with gut microbiome modified by neomycin (−28%, p = 0.002) and was increased in the group in which the gut microbiome was altered by sweetener alone (+39%, p < 0.001). Analysis of the fecal microbiota detected seven lower-ranked taxa differentially abundant in animals with impaired tissue-level strength and 14 differentially abundant taxa associated with increased tissue-level strength. Histological and serum markers of bone turnover and trabecular bone volume per tissue volume (BV/TV) did not differ among groups. These findings demonstrate that modifications to the taxonomic components of the gut microbiome have the potential to decrease or increase tissue-level strength of bone independent of bone quantity and without noticeable changes in bone turnover. © 2021 American Society for Bone and Mineral Research (ASBMR). 相似文献
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Osteosarcomatosis 总被引:10,自引:0,他引:10
Hopper KD; Moser RP Jr; Haseman DB; Sweet DE; Madewell JE; Kransdorf MJ 《Radiology》1990,175(1):233-239
A review of the 690 cases of osteosarcoma in the radiographic file of the Armed Forces Institute of Pathology revealed 29 cases of "osteosarcomatosis" (multiple skeletal sites of osteosarcoma). Fifteen of these patients were 18 years old and under and manifested rapidly appearing, usually symmetric, sclerotic metaphyseal lesions. The remaining 14 patients were more than 18 years old and had fewer, asymmetric sclerotic lesions. In most patients (28 of 29), a radiographically dominant skeletal tumor was seen. Pulmonary metastases occurred in the majority of patients and were detected at the same time as the bone lesions. These 29 patients were studied with regard to demographic data and skeletal distribution and radiographic appearance of their lesions. As a result of the findings, a metastatic origin from a primary dominant osteosarcoma is favored over a multifocal origin as the basis for osteosarcomatosis. Osteosarcomatosis is more commonly encountered in the mature skeleton than has been previously recognized. 相似文献
56.
Reactive Airways Dysfunction Syndrome (RADS) has been described following exposure to various irritant gases(1). We describe a case of RADS occurring following exposure to chlorine gas and which has persisted at 6 years follow-up. 相似文献
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Chronic avulsive injury of the deltoid insertion in adolescents: imaging findings in three cases 总被引:1,自引:0,他引:1
The clinical and imaging (magnetic resonance [MR] imaging, radiography, and bone scintigraphy) findings in three adolescent boys with chronic avulsive injury at the deltoid insertion are presented. MR imaging enabled the exclusion of findings suggestive of malignancy and the localization of abnormalities to the deltoid insertion site. Findings included cortical thickening and irregularity of the deltoid tubercle, with or without adjacent soft-tissue edema. 相似文献