全文获取类型
收费全文 | 180134篇 |
免费 | 12017篇 |
国内免费 | 4529篇 |
专业分类
耳鼻咽喉 | 2484篇 |
儿科学 | 2577篇 |
妇产科学 | 2351篇 |
基础医学 | 26305篇 |
口腔科学 | 3999篇 |
临床医学 | 18362篇 |
内科学 | 30601篇 |
皮肤病学 | 4693篇 |
神经病学 | 13100篇 |
特种医学 | 9539篇 |
外国民族医学 | 19篇 |
外科学 | 22422篇 |
综合类 | 9426篇 |
现状与发展 | 17篇 |
一般理论 | 37篇 |
预防医学 | 10231篇 |
眼科学 | 4460篇 |
药学 | 17071篇 |
51篇 | |
中国医学 | 4274篇 |
肿瘤学 | 14661篇 |
出版年
2024年 | 236篇 |
2023年 | 1667篇 |
2022年 | 4663篇 |
2021年 | 7012篇 |
2020年 | 4053篇 |
2019年 | 4627篇 |
2018年 | 5489篇 |
2017年 | 4671篇 |
2016年 | 5571篇 |
2015年 | 7919篇 |
2014年 | 9396篇 |
2013年 | 10433篇 |
2012年 | 15467篇 |
2011年 | 15296篇 |
2010年 | 9401篇 |
2009年 | 7798篇 |
2008年 | 10565篇 |
2007年 | 10169篇 |
2006年 | 9220篇 |
2005年 | 8647篇 |
2004年 | 7141篇 |
2003年 | 6588篇 |
2002年 | 5605篇 |
2001年 | 4338篇 |
2000年 | 3788篇 |
1999年 | 3090篇 |
1998年 | 1479篇 |
1997年 | 1218篇 |
1996年 | 872篇 |
1995年 | 880篇 |
1994年 | 703篇 |
1993年 | 523篇 |
1992年 | 1020篇 |
1991年 | 898篇 |
1990年 | 808篇 |
1989年 | 728篇 |
1988年 | 586篇 |
1987年 | 593篇 |
1986年 | 457篇 |
1985年 | 429篇 |
1984年 | 309篇 |
1983年 | 212篇 |
1982年 | 162篇 |
1981年 | 186篇 |
1980年 | 145篇 |
1979年 | 238篇 |
1978年 | 168篇 |
1976年 | 140篇 |
1974年 | 149篇 |
1973年 | 133篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
81.
Paclitaxel with Cisplatin as Salvage Treatment for Patients with Previously Treated Advanced Transitional Cell Carcinoma of the Urothelial Tract 下载免费PDF全文
82.
83.
84.
Lin Bo Wang Jian Guo Shen Li Feng Dong Chao Yang Xu Wen Jun Chen Shu Duo Xie Xiang Yang Song Ning Dai Xiao Ming Yuan 《Journal of gastrointestinal surgery》2008,12(8):1359-1363
We previously reported that lymphatic mapping using isosulfan blue can be used to identify sentinel nodes (SNs). This study
was undertaken to evaluate the feasibility of using the SN technique in treating early gastric cancer and to explore its usefulness
for minimal invasive surgery. Twenty-three patients with early gastric cancer who underwent SN biopsy were retrospectively
evaluated. Based on SN evaluation, individualized surgery was performed in five patients with T1N0M0 gastric cancer. When
pathological examination of frozen sections revealed metastasis in SNs, we performed a standard D2 gastrectomy. Laparoscopic
local resection was applied when the SN biopsy was negative. Our results showed that the success rate with SN biopsy in early
gastric cancer was 100%, as were the accuracy, sensitivity, and specificity. All five patients with early gastric cancer had
SNs negative for metastases both by frozen section and by postoperative pathology. Thus, all these patients underwent laparoscopic
local resection without extended lymphadenectomy. We conclude that SN biopsy is a useful tool to individualize the operative
procedure, and laparoscopic local resection can be safely performed using SN guidance in selected patients with early gastric
cancer. 相似文献
85.
Seunghan Ha Minhee Lee Onseok Lee Gunwoo Lee Jeayoung Kim Jongsub Moon Mingi Kim Chilhwan Oh 《Skin research and technology》2009,15(2):200-213
Background/aims: The objective and quantitative assessment of the skin is important in medical and cosmeceutical research. Assessment of color is an important element for analyzing the surface of the skin, which is usually determined subjectively by a doctor or using color analysis devices. These devices, however, cannot provide correct color information because color is construed from the mean value of the observation region, and analysis of color distribution is impossible. The purpose of this paper is to develop an objective analysis method to permit skin color measurement of each pixel unit of an image and analyze the distribution of skin surface color. Methods: The Skin Color Distribution Analyzer (SCDA) is an analysis method newly developed at the Research Institute for Skin Image at Korea University. The SCDA system presented in this paper performed a novel form of quantitative and objective analysis of skin color distribution using each pixel color model parameter found in image wavelength information. In this paper, distribution analysis was conducted on normal skin and skin lesions and skin affected by artificially induced irritant contact dermatitis and pigmented nevous. The method selected a grade using a color model parameter. Twenty healthy Korean males participated in this study. A comparative study of the eight anatomical areas was performed, including the exposure and non‐exposure parts and the medial aspect and the lateral aspect of the forearm. A reliability test for the SCDA system was also conducted with a spectrometer (SPEC) using the color analysis method. Results: Each skin lesion was precisely segmented by grade and each parameter hada different statistical significance for results of analysis of distribution in pigmented nevous and the artificially induced irritant contact dermatitis. Parameters L*, b*, a*, and EI showed salient traits. Showed resemble measured result in the SCDA system and the SPEC of normal skin. The exposed site, in comparison with the non‐exposed site, showed a notable difference in the L* parameter and a significant statistical difference in the x and z parameters, except b*. The comparison of the medial and lateral aspects of the forearm showed a notable difference in the L* parameter and a significant statistical difference in the parameters except y and b*. In the reliability test result using the SCDA system and the SPEC, the SCDA system was highly reliabile in terms of the CV value in all color model parameters. Conclusions: The color distribution analysis method using the SCDA system has revealed an aspect that the existent method of medical research has not shown, and is considered to be more reliable than other methods. This method can provide better study findings because it can be applied to other fields in addition to the medical science field and the ripple effect is thought to be bigger in other science field too. 相似文献
86.
87.
Increased lymphocyte beta-adrenergic receptor density in progressive multiple sclerosis is specific for the CD8+, CD28- suppressor cell. 总被引:1,自引:0,他引:1
Beta-adrenergic receptor density on T cells from healthy humans is greatest on suppressor cells (CD8+, CD28-) and the effect of catecholamines, secreted by the sympathetic nervous system, predominates on this subset. The sympathetic skin response, a measure of sympathetic nervous system function, is absent in most patients with chronic progressive multiple sclerosis (MS). We measured beta-adrenergic receptor density on suppressor cells, cytotoxic cells, and monocytes from patients with chronic progressive MS and healthy control subjects. Control receptor density on suppressor cells was 2.8 +/- 0.3 fmol/10(6) cells versus a density of 5.1 +/- 0.7 fmol/10(6) cells for patients. Cytotoxic cell (CD8+, CD28+) receptor density was 1.4 +/- 0.4 fmol/10(6) cells in control subjects and 0.9 +/- 0.3 fmol/10(6) cells in the patients. Monocytes displayed beta-adrenergic receptor densities of 2.6 +/- 0.4 fmol/10(6) cells in normal individuals and 2.7 +/- 0.4 fmol/10(6) cells in the patient group. CD8 lymphocyte beta-adrenergic receptor densities in patients with relapsing-remitting and those with stable MS were not different from control values, yet were significantly less than the values for patients with chronic progressive MS. We find that mononuclear cells from healthy control subjects and patients with chronic progressive MS proliferate in response to 200 units/ml of recombinant human interleukin-2 (IL-2) similarly. However, IL-2 treatment increased beta-adrenergic receptor density on normal mononuclear cells, but failed to increase it on mononuclear cells from patients with chronic progressive MS.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
88.
89.
目的:探讨急性重症胆管炎患者的手术时机和死亡原因。方法:回顾性分析23例急性重症胆管炎患者的治疗及预后情况。结果:死亡2例(手术死亡及传统治疗死亡各1例)。早期大剂量短期应用糖皮质激素患者休克得到纠正率85%,明显高于未用糖皮质激素患者休克纠正率50%。结论:急性重症胆管炎患者应在出现休克和(或)精神症状之前手术,对已出现休克的患者,应先给予充分的保守治疗,待病情稳定后再手术。贻误手术时机,严重合并症如多器官功能衰竭及高龄是死亡的主要原因。 相似文献
90.
心血管疾病并发焦虑抑郁症状2050例心理干预治疗分析 总被引:13,自引:1,他引:12
目的:了解心血管疾病并发焦虑抑郁症状的情况并探讨心理干预等对焦虑抑郁症状的影响。方法:对住院的2050例心血管疾病并发焦虑抑郁症状的患者进行回顾性分析。结果:心血管疾病患者中并发有焦虑抑郁症状者占56%;其常表现为类似心绞痛、左心衰竭症状,可并发有心律失常;高血压病并发有焦虑抑郁患者对血压升高的耐受性差,动态血压检查以非勺型改变者居多;单纯使用心血管药物治疗效果欠佳,心理干预,焦虑抑郁症状严重者结合抗焦虑抑郁药物疗效显著。结论:心血管疾病患者常并发焦虑抑郁症状,心理干预治疗等可有效改善患者的症状。 相似文献