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101.
Bahare Salehi Dmitry A. Konovalov Pascaline Fru Petrina Kapewangolo Gregorio Peron Mileski S. Ksenija Susana M. Cardoso Olivia R. Pereira Manisha Nigam Silvana Nicola Giuseppe Pignata Simona Rapposelli Simona Sestito Nanjangud V. Anil Kumar María de la Luz Cdiz‐Gurrea Antonio Segura‐Carretero Abhay P. Mishra Mehdi Sharifi‐Rad William C. Cho Yasaman Taheri William N. Setzer Javad Sharifi‐Rad 《Phytotherapy research : PTR》2020,34(9):2140-2158
The family Arecaceae includes 181 genera and 2,600 species with a high diversity in physical characteristics. Areca plants, commonly palms, which are able to grow in nearly every type of habitat, prefer tropical and subtropical climates. The most studied species Areca catechu L. contains phytochemicals as phenolics and alkaloids with biological properties. The phenolics are mainly distributed in roots followed by fresh unripe fruits, leaves, spikes, and veins, while the contents of alkaloids are in the order of roots, fresh unripe fruits, spikes, leaves, and veins. This species has been reputed to provide health effects on the cardiovascular, respiratory, nervous, metabolic, gastrointestinal, and reproductive systems. However, in many developing countries, quid from this species has been associated with side effects, which include the destruction of the teeth, impairment of oral hygiene, bronchial asthma, or oral cancer. Despite these side effects, which are also mentioned in this work, the present review collects the main results of biological properties of the phytochemicals in A. catechu. This study emphasizes the in vitro and in vivo antioxidant, antimicrobial, anticancer, and clinical effectiveness in humans. In this sense, A. catechu have demonstrated effectiveness in several reports through in vitro and in vivo experiments on disorders such as antimicrobial, antioxidant, or anticancer. Moreover, our findings demonstrate that this species presents clinical effectiveness on neurological disorders. Hence, A. catechu extracts could be used as a bioactive ingredient for functional food, nutraceuticals, or cosmeceuticals. However, further studies, especially extensive and comprehensive clinical trials, are recommended for the use of Areca in the treatment of diseases. 相似文献
102.
Ekaterina A Polyakova Evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza 《老年心脏病学杂志》2021,18(1):47-66
Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the"ideal biomarker."A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis. 相似文献
103.
Ivan Vasilievich Bodrikov Anna Gennadevna Ivanova Alexander Leonidovich Vasiliev Evgeny Yurievich Titov Dmitry Yurievich Titov Anton Igorevich Serov 《RSC advances》2021,11(62):39428
The directions of the transformation of benzene induced by low-voltage discharges at various energies of pulsed discharges were revealed. This paper shows the dependencies of the morphology and other characteristics of nanostructures obtained in the induced transformation of benzene on the energy of pulsed discharges. Nanostructures with different morphologies are formed when the energy of the low-voltage discharges changes during the induced transformation of benzene in the liquid phase. Two types of carbon nanostructures were formed in the induced destruction of benzene with a 90 μF capacitor. The first type of structure includes graphite fibers, two- and three-layer graphene sheets, as well as two- and three-layer hollow spheres and microstructures in the form of CNHs. The microstructures of the second type were onion-like spheroids. An increase in the capacitance up to 20 090 μF led to the formation of two types of nanostructures: onion-like spheroids and carbon fibers. A further increase in the capacitance to 40 090 μF caused the formation of onion-like spheroids.The first type microstructure in the sample 90 μF: (a) BF TEM image of the graphene layers with hollow spheres (arrowed) and the area with graphite (marked by G). 相似文献
104.
105.
Vetrova Marina V. Cheng Debbie M. Bendiks Sally Gnatienko Natalia Lloyd-Travaglini Christine Jiang Wenqing Luoma Jason Blokhina Elena Krupitsky Evgeny Lioznov Dmitry Ekstrand Maria L. Raj Anita Samet Jeffrey H. Lunze Karsten 《AIDS and behavior》2021,25(9):2815-2826
AIDS and Behavior - Little is known about the intersection of HIV stigma and substance use stigma. Using data from 188 HIV-positive people who inject drugs (PWID) in Russia, we examined the... 相似文献
106.
Hydrogen‐Bonding Effects for the C–ON Bond Homolysis and Reformation Reactions of Alkoxyamines 下载免费PDF全文
Elena G. Bagryanskaya Paul Brémond Teddy Butscher Sylvain R. A. Marque Dmitry Parkhomenko Valérie Roubaud Didier Siri Stéphane Viel 《Macromolecular chemistry and physics.》2015,216(5):475-488
N‐(2‐methylpropyl)‐N‐(1‐diethylphosphono‐2,2‐dimethylpropyl)‐O‐(2‐carboxyprop‐2‐yl) hydroxylamine (BlocBuilder MA) is, among the commercially available alkoxyamines, one of the most efficient for nitroxide‐mediated polymerization (NMP). However, recent results have shown that it does not perform well for the NMP of isoprene. The occurrence of intramolecular hydrogen bonding (IHB) between the carboxylic function and the diethoxyphosphoryl group has been proposed as the reason for its low efficiency. In this article, the presence of this IHB is confirmed using IR, 31P NMR, 31P‐1H HOESY, and DFT calculation results. The solvent effect on this IHB and consequently on kd values is also investigated. However, combining kinetic analysis and rate measurements in various solvents, the influence of this IHB on the C? ON bond homolysis and reformation in alkoxyamine is shown to be very weak.
107.
Tiffany C. Ho Boris Gutman Elena Pozzi Hans J. Grabe Norbert Hosten Katharina Wittfeld Henry Vlzke Bernhard Baune Udo Dannlowski Katharina Frster Dominik Grotegerd Ronny Redlich Andreas Jansen Tilo Kircher Axel Krug Susanne Meinert Igor Nenadic Nils Opel Richard Dinga Dick J. Veltman Knut Schnell Ilya Veer Henrik Walter Ian H. Gotlib Matthew D. Sacchet Andr Aleman Nynke A. Groenewold Dan J. Stein Meng Li Martin Walter Christopher R. K. Ching Neda Jahanshad Anjanibhargavi Ragothaman Dmitry Isaev Artemis Zavaliangos-Petropulu Paul M. Thompson Philipp G. Smann Lianne Schmaal 《Human brain mapping》2022,43(1):341-351
Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, ENIGMA, to identify reliable neural correlates of major depressive disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work by precisely mapping localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with adolescent-onset MDD (≤ 21 years) had lower thickness and surface area of the subiculum, cornu ammonis (CA) 1 of the hippocampus and basolateral amygdala (Cohen's d = ?0.164 to ?0.180). Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala (Cohen's d = ?0.173 to ?0.184). Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features. 相似文献
108.
109.
Martin E. Gosnell Dmitry M. Polikarpov Ewa M. Goldys Andrei V. Zvyagin David A. Gillatt 《Urologic oncology》2018,36(1):8.e9-8.e15
Objectives
One of the most reliable methods for diagnosing bladder cancer is cystoscopy. Depending on the findings, this may be followed by a referral to a more experienced urologist or a biopsy and histological analysis of suspicious lesion. In this work, we explore whether computer-assisted triage of cystoscopy findings can identify low-risk lesions and reduce the number of referrals or biopsies, associated complications, and costs, although reducing subjectivity of the procedure and indicating when the risk of a lesion being malignant is minimal.Materials and methods
Cystoscopy images taken during routine clinical patient evaluation and supported by biopsy were interpreted by an expert clinician. They were further subjected to an automated image analysis developed to best capture cancer characteristics. The images were transformed and divided into segments, using a specialised color segmentation system. After the selection of a set of highly informative features, the segments were separated into 4 classes: healthy, veins, inflammation, and cancerous. The images were then classified as healthy and diseased, using a linear discriminant, the naïve Bayes, and the quadratic linear classifiers. Performance of the classifiers was measured by using receiver operation characteristic curves.Results
The classification system developed here, with the quadratic classifier, yielded 50% false-positive rate and zero false-negative rate, which means, that no malignant lesions would be missed by this classifier.Conclusions
Based on criteria used for assessment of cystoscopy images by medical specialists and features that human visual system is less sensitive to, we developed a computer program that carries out automated analysis of cystoscopy images. Our program could be used as a triage to identify patients who do not require referral or further testing. 相似文献110.
Dura to spinal cord distance at different vertebral levels in children and its implications on epidural analgesia: A retrospective MRI‐based study 下载免费PDF全文