全文获取类型
收费全文 | 90篇 |
免费 | 3篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 17篇 |
口腔科学 | 7篇 |
临床医学 | 7篇 |
内科学 | 26篇 |
皮肤病学 | 1篇 |
神经病学 | 5篇 |
特种医学 | 1篇 |
外科学 | 4篇 |
预防医学 | 9篇 |
药学 | 11篇 |
中国医学 | 1篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 11篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 5篇 |
2013年 | 3篇 |
2012年 | 5篇 |
2011年 | 11篇 |
2010年 | 4篇 |
2009年 | 2篇 |
2008年 | 5篇 |
2007年 | 5篇 |
2006年 | 2篇 |
2005年 | 4篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 1篇 |
2001年 | 4篇 |
1998年 | 1篇 |
1991年 | 1篇 |
1988年 | 3篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有93条查询结果,搜索用时 15 毫秒
31.
Steven B. Deitelzweig Brett Pinsky Erin Buysman Michael Lacey Dinara Makenbaeva Daniel Wiederkehr John Graham 《Clinical therapeutics》2013
Background
Patients with nonvalvular atrial fibrillation (NVAF) are at increased risk for stroke and bleeding events, but bleeding as an outcome has not been extensively studied in this patient population.Objectives
The goal of this study was to estimate the incidence of bleeding events among patients with NVAF enrolled in managed care, investigate the relationships between bleeding incidence and bleeding and stroke risks, and estimate health care costs for patients who had a major bleeding event.Methods
Adults with commercial insurance or Medicare Advantage coverage and health care claims related to AF between January 2005 and June 2009 but with no evidence of valvular disease were included in this retrospective claims data analysis. Baseline stroke risk (CHADS2 [Congestive Heart Failure, Hypertension, Age >75 Years, Diabetes Mellitus, and Prior Stroke or Transient Ischemic Attack]) and bleeding risk (HAS-BLED [Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile International Normalized Ratios, Elderly, Drugs/Alcohol]) were estimated. Bleeding events were identified during the variable follow-up period, which lasted from the date of the first qualifying AF visit until the earlier of death, disenrollment from the health plan, or June 30, 2010. Bleeding events were classified as major, serious nonmajor, or minor. Health care costs for patients with major bleeding events were calculated.Results
Among 48,260 patients with NVAF (mean age, 67 years), 34% had an incident bleeding event during a mean (SD) follow-up period of 802 (540) days. Incidence rates for bleeding events of any severity and major events were 29.6 and 10.4 per 100 patient-years, respectively. Bleeding incidence rates increased with greater CHADS2 and HAS-BLED risk scores. All-cause health care costs for patients during a major bleeding event averaged $16,830. Average costs per patient with a major event increased from approximately $52 per day in the prebleeding period to approximately $63 per day in the postbleeding period. Costs for patients who did not experience a major bleeding event averaged approximately $38 per day.Conclusions
Bleeding incidence among patients with NVAF in a real-world setting was high and increased with greater stroke and bleeding risk scores. Health care costs for patients with major bleeding events were elevated. All rights reserved. 相似文献32.
33.
34.
Antioxidant and anti-mutagenic effects of ebselen in yeast and in cultured mammalian V79 cells 总被引:1,自引:0,他引:1
Ebselen has a wide spectrum of interesting therapeutic actions including antioxidant, cytoprotective, neuroprotective and anti-inflammatory activities. Since its antioxidant effect is very well known, this paper links the effects of ebselen in redox cellular status to its possible involvement in the maintenance of the integrity of genomic information by using Saccharomyces cerevisiae strains proficient and deficient in antioxidant defences and the mammalian V79 cell line. Using the alkaline comet assay, we showed that 5-10 microM ebselen does not induce DNA damage in V79 cells. Similarly, these same concentrations diminished the extent of the DNA damage induced by hydrogen peroxide (H(2)O(2)). The modified comet assay using DNA glycosylases (formamidopyrimidine-DNA glycosylase and endonuclease II) showed that after pre-treatment with ebselen followed by exposure to H(2)O(2), oxidative damage as recognized by these enzymes was significantly lower. In the same way, ebselen showed strong activity against H(2)O(2)-induced oxidative damage in the anti-mutagenic assay using S. cerevisiae N123 strain and in the antioxidative assay by using S. cerevisiae strains lacking antioxidant defences. This antioxidant effect was more pronounced for the gpx3 delta mutant, which indicated that ebselen acts by mimicking the GPx3 catalytic activity. The results confirm that ebselen is involved in antioxidant defence and that its antioxidant ability contributes to its anti-mutagenic and anti-genotoxic action. 相似文献
35.
Saule Kolumbayeva Dinara Begimbetova Tamara Shalakhmetova Timur Saliev Anna Lovinskaya Benazir Zhunusbekova 《Ecotoxicology (London, England)》2014,23(7):1283-1291
An assessment of the health status of ecosystems exposed to man-made pollution is a vital issue for many countries. Particularly it concerns the consequences of contamination caused by the activity of the space industry. Each rocket launch is accompanied by the introduction of parts of the rocket propellant into the environment. This study aims to scrutinize the effect of the components of rocket fuel on the induction of lipid peroxidation and chromosomal aberrations on rodents inhabiting the area exposed to pollution from Baikonur cosmodrome. The results showed the increase of the level of lipid hydroperoxide and malondialdehyde in the livers of Citellus pygmaeus Pallas and Mus musculus L., which indicates an augmentation of free radical activity and DNA damage. The cytogenetic analysis of bone marrow cells revealed that the frequency of chromosomal aberrations was a few times higher in the rodents from contaminated territory. The signs of oxidative stress and high level of chromosomal aberrations indicate the environmental impact of the cosmodrome, and its possible toxic and mutagenic effects on ecosystems. 相似文献
36.
Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy 总被引:3,自引:0,他引:3
Perrot A Schmidt-Traub H Hoffmann B Prager M Bit-Avragim N Rudenko RI Usupbaeva DA Kabaeva Z Imanov B Mirrakhimov MM Dietz R Wycisk A Tendera M Gessner R Osterziel KJ 《Journal of molecular medicine (Berlin, Germany)》2005,83(6):468-477
Hypertrophic cardiomyopathy (HCM) is a frequent, autosomal-dominant cardiac disease and manifests predominantly as left ventricular hypertrophy. Mutations in the cardiac beta-myosin heavy chain gene (MYH7) are responsible for the disease in about 30% of cases where mutations were identified. We clinically evaluated a large group of 147 consecutive HCM patients from three cardiology centers in Germany, Poland, and Kyrgyzstan according to the same protocol. The DNA of the patients was systematically analyzed in the whole coding region of the MYH7 gene using PCR, single-strand conformation polymorphism analysis, and automated sequencing. Eleven different missense mutations (including seven novel ones) in 11 unrelated patients were identified, showing a mutation frequency of 7.5% in the study population. We further examined the families of five patients (three of German, one of Polish, and one of Kyrgyz origin) with 32 individuals in total. We observed a clear, age-dependent penetrance with onset of disease symptoms in the fourth decade of life. Genotype–phenotype correlations were different for each mutation, whereas the majority was associated with an intermediate/malign phenotype. In conclusion, we report a systematic molecular screening of the complete MYH7 gene in a large group of consecutive HCM patients, leading to a genetic diagnosis in 38 individuals. Information about the genotype in an individual from one family could be very useful for the clinician, especially when dealing with healthy relatives in doubt of their risk about developing HCM. The increasing application of genetic screening and the increasing knowledge about genotype–phenotype correlations will hopefully lead to an improved clinical management of HCM patients.An erratum to this article can be found at
Andreas Perrot and Hajo Schmidt-Traub contributed equally to this work 相似文献
37.
38.
Shakiryanova D Zettel GM Gu T Hewes RS Levitan ES 《Proceedings of the National Academy of Sciences of the United States of America》2011,108(11):4477-4481
Synaptic release of neurotransmitters is evoked by activity-dependent Ca(2+) entry into the nerve terminal. However, here it is shown that robust synaptic neuropeptide release from Drosophila motoneurons is evoked in the absence of extracellular Ca(2+) by octopamine, the arthropod homolog to norepinephrine. Genetic and pharmacology experiments demonstrate that this surprising peptidergic transmission requires cAMP-dependent protein kinase, with only a minor contribution of exchange protein activated by cAMP (epac). Octopamine-evoked neuropeptide release also requires endoplasmic reticulum Ca(2+) mobilization by the ryanodine receptor and the inositol trisphosphate receptor. Hence, rather than relying exclusively on activity-dependent Ca(2+) entry into the nerve terminal, a behaviorally important neuromodulator uses synergistic cAMP-dependent protein kinase and endoplasmic reticulum Ca(2+) signaling to induce synaptic neuropeptide release. 相似文献
39.
Guseinova D Consolaro A Trail L Ferrari C Pistorio A Ruperto N Buoncompagni A Pilkington C Maillard S Oliveira SK Sztajnbok F Cuttica R Corona F Katsicas MM Russo R Ferriani V Burgos-Vargas R Solis-Vallejo E Bandeira M Baca V Saad-Magalhaes C Silva CA Barcellona R Breda L Cimaz R Gallizzi R Garozzo R Martino S Meini A Stabile A Martini A Ravelli A 《Clinical and experimental rheumatology》2011,29(1):117-124
40.
Rachana Hasija Angela Pistorio Angelo Ravelli Erkan Demirkaya Raju Khubchandani Dinara Guseinova Clara Malattia Helena Canhao Liora Harel Dirk Foell Carine Wouters Carmen De Cunto Christian Huemer Yukiko Kimura Harald Mangge Carlo Minetti Ellen Berit Nordal Pierre Philippet Rosaria Garozzo Alberto Martini Nicolino Ruperto 《Arthritis \u0026amp; Rheumatology》2011,63(10):3142-3152