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Nikolaos Samaras Dimitrios Samaras Pierre-Olivier Lang Alexandre Forster Claude Pichard Emilia Frangos Patrick Meyer 《Maturitas》2013,74(3):213-219
Age related male hypogonadism, or “andropause”, is increasingly recognized as of frequent occurrence in older patients. Diagnosis requires both the presence of clinical symptoms and low testosterone levels. However, diagnosing andropause in this age group may be challenging since symptoms are frequently non specific and testosterone levels are influenced by a multitude of parameters such as lifestyle factors and chronic diseases. In this article we discuss the pathophysiology, definition and diagnostic difficulties of andropause in geriatric patients. Moreover, we review the relation between testosterone levels and frequent geriatric syndromes such as falls, osteoporosis, cognitive and mood disorders, anemia and cardiovascular disease. Finally, we examine the potential benefits and risks of testosterone replacement therapy in this age group. 相似文献
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Pawan Sinha Margaret M. Kjelgaard Tapan K. Gandhi Kleovoulos Tsourides Annie L. Cardinaux Dimitrios Pantazis Sidney P. Diamond Richard M. Held 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(42):15220-15225
A rich collection of empirical findings accumulated over the past three decades attests to the diversity of traits that constitute the autism phenotypes. It is unclear whether subsets of these traits share any underlying causality. This lack of a cohesive conceptualization of the disorder has complicated the search for broadly effective therapies, diagnostic markers, and neural/genetic correlates. In this paper, we describe how theoretical considerations and a review of empirical data lead to the hypothesis that some salient aspects of the autism phenotype may be manifestations of an underlying impairment in predictive abilities. With compromised prediction skills, an individual with autism inhabits a seemingly “magical” world wherein events occur unexpectedly and without cause. Immersion in such a capricious environment can prove overwhelming and compromise one’s ability to effectively interact with it. If validated, this hypothesis has the potential of providing unifying insights into multiple aspects of autism, with attendant benefits for improving diagnosis and therapy. 相似文献
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Vitamin D supplements have increasingly been used for the treatment and prevention of osteoporosis. Historically, effects of the vitamin on the cardiovascular (CV) system have been proposed and demonstrated in the literature, including benefits on serum lipids. Although observational studies support an association between increased serum vitamin D levels and a favorable lipid profile, interventional studies have shown no effects. 相似文献
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Miltiades Kastanakis Dimitrios Anyfantakis Nikolaos Katsougris Emmanouil Bobolakis 《International journal of surgery case reports》2013,4(5):439-441
INTRODUCTIONIsolated ectopic varices located in the small bowel are uncommon. Portal hypertension caused by liver cirrhosis is the most common predisposing risk factor.PRESENTATION OF CASEWe present an unusual case of massive gastrointestinal bleeding from idiopathic jejunal varices in a 73-year-old Caucasian male without portal hypertension. Exploratory laparotomy disclosed ectopic varices located in the small intestine. Segmental resection of the jejunum with end to end anastomosis resulted in a complete resolution of the haemorrhage. During a 5 year follow up, the patient is stable with no bleeding recurrence.DISCUSSIONInformation on aetiology, diagnosis and management of jejunal varices is reviewed.CONCLUSIONDiagnosis and management of isolated jejunal varices is challenging. Surgeons as well as acute care physicians have to consider idiopatic form of jejunal varices as a potential cause of gastrointestinal bleeding when gastroduodenoscopy and colonoscopy are negative. 相似文献
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Aikaterini Patsatsi M.D. Aikaterini Kyriakou M.D. M.Sc. Dimitrios Sotiriadis M.D. 《Pediatric dermatology》2014,31(5):547-550
Benign cephalic histiocytosis (BCH) is a rare type of non‐Langerhans histiocytic disorder, usually presenting with small, yellow‐red or yellow‐brown, asymptomatic papules, located mostly on the head and neck of infants and young children. The histopathologic hallmark of BCH is a well‐circumscribed histiocytic infiltrate in the superficial to mid‐reticular dermis. BCH is a self‐healing disorder, with the eruptions regressing spontaneously in most cases; therefore no treatment is required. We present a case of BCH in a 7‐month‐old boy who was referred to our department with multiple, asymptomatic, yellow‐red papules located on his face, and we review 55 cases published in the English‐language literature in an effort to better describe and understand this unusual entity. 相似文献
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