Regression of pulmonary MALT lymphoma after treatment with rituximab

We describe a patient with extranodal (pulmonary) marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) who was refractory to treatment with cytotoxic chemotherapy. After a single four-week course of rituximab she had significant regression of pulmonary lesions and remains progression free 19 months after finishing her treatment. This case report demonstrates the potential efficacy of rituximab as a single therapeutic agent in patients with pulmonary MALT lymphoma.     

妊娠期一氧化氮的合成及作用

作为一种信使分子,一氧化氮（ＮＯ）受到各学科的广泛重视。近年来的研究表明,ＮＯ对正常妊娠的维持起着重要作用。下面就妊娠期ＮＯ的合成及作用特点综述如下。一、妊娠期ＮＯ的合成释放量体外研究表明,在内皮细胞密度相同的情况下,妊娠期豚鼠的子宫动脉和颈动脉对乙...     

胰岛素抵抗与妊高征发病及围产儿预后的关系

目的探讨胰岛素抵抗与妊高征发病及围产儿预后的关系。方法选择妊高征孕妇１１１例为妊高征组,正常妊娠妇女１５５例为对照组;分别于孕３２周前和３２周后取母血,分娩后取脐血,测定胰岛素和Ｃ肽浓度;比较新生儿出生体重、Ａｐｇａｒ评分和羊水状况。结果妊高征组Ｃ肽和胰岛素的浓度在孕３２周前、后均明显高于对照组（Ｐ＜０．００１和Ｐ＜０．０１）。在妊高征组,宫内发育迟缓、新生儿窒息和羊水异常时,母儿Ｃ肽和胰岛素浓度均有上升的趋势,并且发生在妊娠３２周之前;在对照组,宫内发育迟缓时,孕妇Ｃ肽和胰岛素浓度有下降的趋势。结论胰岛素抵抗在妊高征的发生、发展,以及围产儿预后不良等方面均有重要意义。     

蜂毒伤致角膜损伤7例分析

将我院 1995～ 1998年所收治的 7例蜂毒伤致角膜损伤报道如下。1　临床资料1.1　一般资料 :男 4例 ,女 3例 ;7～ 15岁 4例 ,4 5～50岁 3例 ,以儿童多见 ,与野外活动有关 ;学生 4例 ,农民 2例 ,家属 1例 ;均为黄蜂。初诊视力 :眼前手动者 1例 ,指数 /50 cm者 2例 ,0 .0 5～ 0 .1者 2例 ,0 .3者 2例。眼部体征 :7例角膜病损 ,弥漫性 2例 ,局限性且形成角膜溃疡 3例 ;合并虹睫炎 7例 ,合并前房积脓 1例。实验室检查 :7例均做白细胞计数及分类 ,总数多为正常或偏高 ,其中有 2例病情严重的分类中嗜伊红细胞增高 ,最高者达 12 % ,WBC在 (7.2～ 1…     

口服米索前列醇混悬液用于足月妊娠引产70例分析

目的 探讨小剂量口服米索前列醇混悬液用于足月妊娠引产的有效性和安全性。方法 １４０例有引产指征的足月孕妇分为两组。Ａ组７０例口服米索混悬液,每２ｈ１次,初起每次２０ｍｌ,连续３次后若无规律宫缩出现,第４次起改为每次４０ｍｌ,若出现有效宫缩即停药,否则直至服守２００ｍｌ;Ｂ组７０例静滴催产素引产作为对照组。结果 两组引产成功率分别为８８．５７％和８２．８６％（Ｐ〉０．０５）。Ａ组从开始用药至监产的平     

Protein kinase-dependent phosphorylation and cannabinoid receptor modulation of potassium A current (I A) in cultured rat hippocampal neurons

The potent cannabinoid receptor agonist WIN 55,212-2 produces positive shifts in steady-state inactivation of the potassium A current (IA) in rat hippocampal neurons via an adenosine 3',5'-cyclic monophosphate (cAMP)-, protein kinase A (PKA)-dependent process. This effect is probably mediated by phosphorylation or dephosphorylation of the IA channel protein. The role of protein phosphorylation in this cascade was tested by testing cannabinoid actions in cultured hippocampal neurons (pyramidal cells) that were exposed also to either the catalytic subunit of PKA (PKAc), a PKA-specific phosphorylation inhibitor (IP-20, Walsh peptide), or a potent protein phosphatase inhibitor (okadaic acid). Cannabinoids such as WIN 55,212-2 produce a positive (rightwards) shift in the steady-state inactivation of IA, thus providing increased current at a given membrane voltage. Cells dialyzed with PKAc showed a negative shift in IA inactivation, opposite to that produced by cannabinoids, and similar to that produced by increased levels of cAMP. In addition, PKAc completely blocked the positive shift produced by WIN 55,212-2. In contrast, dialysis of cells with IP-20 produced a positive shift in steady state inactivation of IA, similar to that produced by WIN, but the effects were not additive with cannabinoid receptor activation. The phosphatase inhibitor, okadaic acid produced a small negative shift in IA steady-state inactivation when administered alone, and blocked the positive shift produced by WIN 55,212-2. Okadaic acid also enhanced the negative shift in IA inactivation when co-administered with forskolin. The effects of okadaic acid and WIN 55,212-2 were not additive, suggesting a common pathway. These results demonstrate that IA is altered by direct manipulations of the phosphorylation status of the channel protein, and that cannabinoid effects on IA are probably mediated by dephosphorylation of the IA channel.     

Regulation of dedifferentiation and redifferentiation in renal proximal tubular cells by the epidermal growth factor receptor

Repair of injured renal epithelium is thought to be mediated by surviving renal proximal tubular cells (RPTC) that must dedifferentiate to allow the proliferation and migration necessary for epithelial regeneration. RPTC then redifferentiate to restore tubular structure and function. Current models suggest that epidermal growth factor receptor (EGFR) activation is required for dedifferentiation characterized by enhanced vimentin expression, decreased N-cadherin expression, spindle morphology, and loss of apical-basal polarity after injury. Because an in vitro model of RPTC redifferentiation has not been reported, and the mechanism(s) of redifferentiation has not been determined, we used rabbit RPTC in primary cultures to address these issues. H2O2 induced the dedifferentiated phenotype that persisted >48 h; redifferentiation occurred spontaneously in the absence of exogenous growth factors after 72 to 120 h. Phosphorylation of two tyrosine residues of EGFR increased 12 to 24 h, peaked at 24 h, and declined to basal levels by 48 h after injury. EGFR inhibition during dedifferentiation restored epithelial morphology and apical-basal polarity, and it decreased vimentin expression to control levels 24 h later. In contrast, exogenous epidermal growth factor addition increased vimentin expression and potentiated spindle morphology. p38 mitogen-activated protein kinase (MAPK) and transforming growth factor (TGF)-beta receptor inhibitors did not affect redifferentiation after H2O2 injury. Similar results were observed in a mechanical injury model. These experiments represent a new model for the investigation of RPTC redifferentiation after acute injury and identify a key regulator of redifferentiation: EGFR, independent of p38 MAPK and the TGF-beta receptor.     

Evaluation of soft-tissue alteration around implant-supported single-tooth restoration in the anterior maxilla: the pink esthetic score

Purpose: To evaluate the alterations of soft tissue around a single‐tooth implant in the anterior maxilla with a new defined pink esthetic score (PES) at the time of crown placement and 6 months post‐loading. Material and methods: According to the case inclusion criteria, 29 patients subjected to single‐tooth replacement with ITI implant‐supported restoration in the anterior maxilla were included. Assessments of soft tissue after crown placement (baseline) and at 6 months (follow‐up) were performed by two orthodontists with PES. Results: No statistically significant difference was found between the two observers. PES for the single‐tooth implant varied from 6.90 to 9.55 at 6‐month follow‐up. The scores of the mesial and distal papilla, level of soft‐tissue margin, soft‐tissue contour, soft‐tissue color and soft‐tissue texture increased significantly at follow‐up. The highest percentage of improvement in PES was found in the cases scoring 0–4 at the baseline. Conclusions: The esthetic outcome of soft tissue around the single‐tooth implant had improved significantly at follow‐up compared with baseline according to PES assessment. The results suggested that the potential for significant changes in soft‐tissue levels after restorative therapy needs to be considered for single‐implant therapy in the anterior maxilla.