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排序方式: 共有97条查询结果,搜索用时 62 毫秒
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Lee MY Lee EY Lee BJ Won CS Koh JH Shin JY Shin YG Cho BP Chung CH 《Yonsei medical journal》2007,48(2):301-307
PURPOSE: Diabetic nephropathy is the most serious of complications in diabetes mellitus. Thiazolidinedione (TZD) is thought to ameliorate diabetic nephropathy; however, the mechanism underlying this effect has not been elucidated. We hypothesized that the vascular endothelial growth factor (VEGF) participates in the pathogenesis of diabetic nephropathy and that TZD may be beneficial for the treatment of diabetic nephropathy because of the effect it has on VEGF. MATERIALS AND METHODS: 23 Otsuka- Long-Evans-Tokushima-Fatty (OLETF) rats and eight control Long-Evans-Tokushima-Otsuka (LETO) rats were divided into the following four groups: LETO group, control OLETF group, pioglitazone treated group (10mg/ kg/day), and rosiglitazone treated group (3mg/kg/day). RESULTS: A progressive increase in urinary protein excretion was observed in the diabetic rats. Glomerular VEGF expression in the control OLETF rats was significantly higher than in the control LETO rats. However, there was a significant reduction in both the glomerular VEGF expression and the VEGF mRNA levels after treatment with pioglitazone and rosiglitazone. The twenty-four hour urine protein levels were significantly decreased in both groups of the treated OLETF rats. CONCLUSION: These results suggest that TZD may have beneficial effects on diabetic nephropathy by reducing the VEGF expression. 相似文献
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Aydın Ece Erdal Çakmak Ünal Uluca Selvi Kelekçi İlyas Yolbaş Ali Güneş Servet Yel İlhan Tan Velat Şen 《Rheumatology international》2014,34(2):207-212
The aim of this study was to determine the Mediterranean fever (MEFV) gene mutations and their clinical correlations in children with familial Mediterranean fever (FMF) in southeast Turkey. Clinical and laboratory characteristics of 147 (65 males, 82 females) consecutive children with FMF having a positive MEFV gene mutation were prospectively investigated. Patients with negative MEFV gene mutations or atypical FMF presentations and those from other regions of the country were excluded. Clinical manifestations and disease severity scores were recorded. The six most frequent MEFV mutations including M694V, V726A, R726H, P369S, E148Q and P369S were investigated by a reverse hybridization test method. The median age of study group was 9.0 years, median age at diagnosis was 7.8 years, median age at disease onset was 5.0 years, and median follow-up duration was 4.0 years. A positive family history of FMF and parent-to-offspring transmission was found in 58.5 and 42.2 % of families, respectively. The frequencies of independent alleles, with decreasing order, were E148Q (30.7 %), M694V (26.0 %), R761H (13.5 %), V726A (13.0 %), P369S (10.5 %) and M680I (6.3 %) in FMF patients. The M694V subgroup had higher mean disease severity score and longer attack duration compared with E148Q and other mutations subgroups (p < 0.05). Two patients with amyloidosis had the M694V homozygote genotype. In conclusion contrast to other regions and many other ethnicities of the world, the most frequent MEFV gene mutation was E148Q in southeast Turkey. The M694V mutation frequency was lower, and disease severity was relatively mild in FMF children of this region. 相似文献
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A successful surgical intervention to restore glenohumeral stability should be based on the detection of all the problems and on a plan to correct all those that are reparable. Contribution of arthroscopy to better understand the pathological anatomy and to evaluate coexisting intra-articular problems, and advances in imaging modalities and in implant technology have increased the success rates and decreased complications. The best way to avoid complications is to gather all the relevant data preoperatively and during surgery to draw the correct diagnosis and to employ the most appropriate approach or approaches accordingly. Complication rates are lower with open surgical techniques, where problems mainly arise from limited joint movements, implant deficiency, and degenerative changes. Although arthroscopic surgery is associated with significantly fewer complications seen with open techniques, it results in higher recurrence rates. Revision surgery for stabilization of the shoulder should be directed to well-defined pathologies using appropriate techniques. The most common complication encountered is the recurrence of instability, which should primarily be dealt with by open surgical techniques. 相似文献
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Antimicrobial susceptibility patterns and macrolide resistance genes of beta-hemolytic streptococci in Korea 总被引:2,自引:0,他引:2
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Uh Y Jang IH Hwang GY Lee MK Yoon KJ Kim HY 《Antimicrobial agents and chemotherapy》2004,48(7):2716-2718
In 540 beta-hemolytic streptococci, the rates of resistance to tetracycline, chloramphenicol, erythromycin, and clindamycin were 80.0, 22.8, 20.2, and 19.1%, respectively. Of the erythromycin-resistant isolates, 63.3% had the constitutive macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotype, 23.9% had the M phenotype, and 12.8% had the inducible MLS(B) resistance phenotype. The constitutive MLS(B) resistance phenotype with the erm(B) gene was dominant in Korea. 相似文献
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Pramil N Singh Daravuth Yel Sovann Sin Sothy Khieng Jaime Lopez Jayakaran Job Linda Ferry Synnove Knutsen 《Bulletin of the World Health Organization》2009,87(12):905-912
Objective
To identify the demographic characteristics of current tobacco users in Cambodia, particularly women, and to explore the reasons for current tobacco use in demographic subgroups of the Cambodian population.Methods
We used a stratified three-stage cluster sample of 13 988 adults aged 18 years and older from all provinces in 2005–2006. Participants completed an interviewer-administered survey that contained items on all forms of tobacco use and on health and lifestyle variables. Multivariable regression analysis was performed to identify demographic predictors of tobacco use.Findings
Cigarette smoking occurred among 48.0% of men and 3.6% of women. We estimated that 560 482 women (95% confidence interval, CI: 504 783 to 616 180) currently chewed tobacco (typically as a component of betel quid) and that the prevalence more than doubles with each decade of adulthood up to the point that about half of all older women chew tobacco. Both men and women cited the influence of older relatives as their primary reason for starting to use tobacco. About one out of five rural women who used chewing tobacco started their habit for relief from morning sickness. The highest prevalence of chewing tobacco among women was seen among midwives (67.9%) and traditional healers (47.2%). High rates (66.8%) of cigarette and pipe tobacco use occurred among ethnic minorities who represent hill tribes found throughout south-east Asia.Conclusion
The tobacco epidemic in Cambodia extends far beyond cigarette smoking in men. Tobacco control that focuses only on cigarettes will not address the health burden from smokeless tobacco use in women that may be an integral part of cultural, familial, and traditional medicine practices. 相似文献9.
Jang Yel Shin Sang Baek Koh Sung Su Oh Young Goo Shin In Deok Kong Choon Hee Chung Jong Ku Park 《Toxicology and Environmental Health Sciences》2009,1(1):69-73
The objective of this study was to assess relationships between adiponectin and the status of glucose metabolism and to investigate whether low adiponectin levels were independently associated with the risk of impaired glucose metabolism and type 2 diabetes in Korean population. A total of 3,508 participants (mean age 56.3±8.0 years; BMI 24.7±3.2 kg/ m2; 41.0% male) were enrolled. Participants with normal glucose metabolism (NGM), impaired glucose metabolism (IGM), and type 2 diabetes were 58.0%, 28.9%, and 13.1%. Adiponectin levels in both men and women were significantly lower in participants with IGM and type 2 diabetes than participants with NGM. Low adiponectin levels in both men and women were strongly associated with the risk of IGM and type 2 diabetes in large population-based cohort of rural adult Koreans. 相似文献
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[Purpose] The present study was aimed to investigate the effects of pulsed and
continuous ultrasound (US) irradiation on heat shock protein (HSP) 70 and mRNA levels of
chondrogenesis-related gene expression in rat tibial articular cartilage. [Subjects and
Methods] Forty-eight rats with body weights of 200−250 g were randomly divided into three
groups. In the control (CON) group, three rats were treated with sham sonication. The
pulsed US irradiation group was irradiated with a pulse rate of 20%, a frequency of 1 MHz,
and an intensity of 1.5 W/cm2 for 10 minutes. The continuous US irradiation
group was continuously with a frequency of 1 MHz and an intensity of 1.5 W/cm2
for 10 minutes. Immunohistochemistry for evaluation of HSP 70 and RT-PCR for expression of
the chondrogenesis-related mRNA were used. [Results] The expression of HSP70 protein was
increased in the pulsed and continuous US groups. The increase in the continuous US group
was more prominent than in the pulsed US group. In addition, pulsed and continuous US
irradiation increased the expression of Mustn1 and Sox9. [Conclusion] The results of this
study show that US increases chondrogenesis via the increase of HSP 70 and
chondrogenesis-related mRNA expressions in rat articular cartilage.Key words: Articular cartilage, Heat shock protein 70, Ultrasound 相似文献