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991.
Heinrich MC; Dooley DC; Freed AC; Band L; Hoatlin ME; Keeble WW; Peters ST; Silvey KV; Ey FS; Kabat D 《Blood》1993,82(3):771-783
992.
Gregory G. Polkowski MD Ryan M. Nunley MD Erin L. Ruh MS Brandon M. Williams DC Robert L. Barrack MD 《Clinical orthopaedics and related research》2012,470(11):2988-2994
Background
Avoiding complications after hip arthroplasty with hard-on-hard bearings, especially metal-on-metal, correlates with the position of the acetabular component. Supine imaging with conventional radiography has traditionally been utilized to assess component inclination (abduction), as well as anteversion, after THA and surface replacement arthroplasty (SRA). However, most adverse events with hard bearings (excessive wear and squeaking) have occurred with loading. Standing imaging, therefore, should provide more appropriate measurements. 相似文献993.
Gustavo Henrique Ferreira Gonalinho Geni Rodrigues Sampaio Rosana Aparecida Manlio Soares-Freitas Ngila Raquel Teixeira Damasceno 《Nutrients》2021,13(6)
Background: This study investigated the association of omega-3 polyunsaturated fatty acids (n-3 PUFA) within erythrocyte membranes and cardiovascular risk assessed by three different estimates. Methods: Inclusion criteria were individuals of both sexes, 30 to 74 years, with at least one cardiovascular risk factor, and no previous cardiovascular events (n = 356). Exclusion criteria were individuals with acute or chronic severe diseases, infectious diseases, pregnant, and/or lactating women. Plasma biomarkers (lipids, glucose, and C-reactive protein) were analyzed, and nineteen erythrocyte membrane fatty acids (FA) were identified. The cardiovascular risk was estimated by Framingham (FRS), Reynolds (RRS), and ACC/AHA-2013 Risk Scores. Three patterns of FA were identified (Factor 1, poor in n-3 PUFA), (Factor 2, poor in PUFA), and (Factor 3, rich in n-3 PUFA). Results: Total cholesterol was inversely correlated with erythrocyte membranes C18:3 n-3 (r = −0.155; p = 0.004), C22:6 n-3 (r = −0.112; p = 0.041), and total n-3 (r = −0.211; p < 0.001). Total n-3 PUFA was associated with lower cardiovascular risk by FRS (OR = 0.811; 95% CI= 0.675–0.976). Regarding RRS, Factor 3 was associated with 25.3% lower odds to have moderate and high cardiovascular risk (OR = 0.747; 95% CI = 0.589–0.948). The ACC/AHA-2013 risk score was not associated with isolated and pooled FA. Conclusions: n-3 PUFA in erythrocyte membranes are independent predictors of low-risk classification estimated by FRS and RRS, which could be explained by cholesterol-lowering effects of n-3 PUFA. 相似文献
994.
Using Tree-Based Recursive Partitioning Methods to Group Haplotypes for Increased Power in Association Studies 总被引:1,自引:0,他引:1
Motivated by the increasing availability of high‐density single nucleotide polymorphism (SNP) markers across the genome, various haplotype‐based methods have been developed for candidate gene association studies, and even for genome‐wide association studies. Although haplotype approaches dramatically reduce the multiple comparisons problem (as compared to single SNP analysis), even the number of existing haplotypes is relatively large, which increases the degrees of freedom and decreases the power for the corresponding test statistic. Grouping haplotypes is a way to reduce the degrees of freedom. We propose a procedure that uses a tree‐based recursive partitioning algorithm to group haplotypes into a small number of clusters, and conducts the association test based on groups of haplotypes instead of individual haplotypes. The method can be used for both population‐based and family‐based association studies, with known or ambiguous phase information. Simulation studies suggest that the proposed method has the right type I error rate, and is more powerful than some existing haplotype‐based tests. 相似文献
995.
Natália A. Matos Josiane F. Silva Tamires C. Matsui Karine A. Damasceno Igor D. G. Duarte Virginia S. Lemos Geovanni D. Cassali André Klein 《Inflammation》2013,36(6):1260-1267
Proteinase-activated receptor (PAR) 2 has been implicated in eosinophil migration. Mast cell (MC) tryptase has been similarly implicated in allergic diseases through the activation of PAR-2, but the role of this receptor in MC tryptase-induced inflammation is not well elucidated. This study aims to investigate the ability of MC tryptase or PAR-2 activating peptide (SLIGRL-NH2) to induce eosinophil recruitment to the pleural cavity of mice. Mast cell tryptase-injected mice were pretreated with PAR-2 antagonist ENMD-1068. Mice injected with SLIGRL-NH2 were pretreated with mast cell tryptase inhibitor APC 366, and eosinophil migration into the pleural cavity and PAR-2 expression was analyzed after 24 or 48 h. SLIGRL-NH2-induced eosinophil recruitment was inhibited by APC 366, and MC tryptase-induced eosinophil recruitment was abolished by ENMD-1068. MC tryptase induced PAR-2 expression on pleural eosinophils. Our results demonstrate a key role for PAR-2 in mediating eosinophil recruitment in MC tryptase-induced pleurisy in mice. The ability of MC tryptase to inducing PAR-2 expression on eosinophils corroborates the relevance of MC tryptase and PAR-2 on modulating eosinophil migration. 相似文献
996.
DC Crawford 《Journal of medical engineering & technology》2013,37(3):108-111
The evaluation of medical devices in the UK has been through many changes since the early hospital equipment assessments in the 1960s. The range of medical devices evaluated has increased and the evaluation reports published have changed, but the evaluation programme continues to be a respected service for the NHS and social care. This review documents the history of the Device Evaluation Service, from its beginnings to the present day, and looks forward to its future. Following an independent strategic review and the Healthcare Industries Task Force (HITF) recommendations, the Device Evaluation Service is now entering a new and exciting developmental phase. 相似文献
997.
L.A.D. Nicolau R.O. Silva S.R.B. Damasceno N.S. Carvalho N.R.D. Costa K.S. Arag?o A.L.R. Barbosa P.M.G. Soares M.H.L.P. Souza J.V.R. Medeiros 《Brazilian journal of medical and biological research》2013,46(8):708-714
Our objective was to investigate the protective effect of Lawesson''s reagent, an
H2S donor, against alendronate (ALD)-induced gastric damage in rats.
Rats were pretreated with saline or Lawesson''s reagent (3, 9, or 27 µmol/kg,
po) once daily for 4 days. After 30 min, gastric damage was
induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the
animals were killed 4 h after ALD administration. Gastric lesions were measured using
a computer planimetry program, and gastric corpus pieces were assayed for
malondialdehyde (MDA), glutathione (GSH), proinflammatory cytokines [tumor necrosis
factor (TNF)-α and interleukin (IL)-1β], and myeloperoxidase (MPO). Other groups were
pretreated with glibenclamide (5 mg/kg, ip) or with glibenclamide (5
mg/kg, ip)+diazoxide (3 mg/kg, ip). After 1 h, 27
µmol/kg Lawesson''s reagent was administered. After 30 min, 30 mg/kg ALD was
administered. ALD caused gastric damage (63.35±9.8 mm2); increased levels
of TNF-α, IL-1β, and MDA (2311±302.3 pg/mL, 901.9±106.2 pg/mL, 121.1±4.3 nmol/g,
respectively); increased MPO activity (26.1±3.8 U/mg); and reduced GSH levels
(180.3±21.9 µg/g). ALD also increased cystathionine-γ-lyase immunoreactivity in the
gastric mucosa. Pretreatment with Lawesson''s reagent (27 µmol/kg) attenuated
ALD-mediated gastric damage (15.77±5.3 mm2); reduced TNF-α, IL-1β, and MDA
formation (1502±150.2 pg/mL, 632.3±43.4 pg/mL, 78.4±7.6 nmol/g, respectively);
lowered MPO activity (11.7±2.8 U/mg); and increased the level of GSH in the gastric
tissue (397.9±40.2 µg/g). Glibenclamide alone reversed the gastric protective effect
of Lawesson''s reagent. However, glibenclamide plus diazoxide did not alter the
effects of Lawesson''s reagent. Our results suggest that Lawesson''s reagent plays a
protective role against ALD-induced gastric damage through mechanisms that depend at
least in part on activation of ATP-sensitive potassium (KATP)
channels. 相似文献
998.
Marcelo Loquette Damasceno Alexandre Foga?a Cristante Raphael Martus Marcon Tarcísio Eloy Pessoa de Barros Filho 《Clinics (S?o Paulo, Brazil)》2014,69(7):452-456
OBJECTIVE:
This study assessed the prevalence of scoliosis and the patterns of scoliotic curves in patients with Williams-Beuren syndrome. Williams-Beuren syndrome is caused by a chromosome 7q11.23 deletion in a region containing 28 genes, with the gene encoding elastin situated approximately at the midpoint of the deletion. Mutation of the elastin gene leads to phenotypic changes in patients, including neurodevelopmental impairment of varying degrees, characteristic facies, cardiovascular abnormalities, hypercalcemia, urological dysfunctions, and bone and joint dysfunctions.METHODS:
A total of 41 patients diagnosed with Williams-Beuren syndrome, who were followed up at the genetics ambulatory center of a large referral hospital, were included in the study. There were 25 male subjects. The patients were examined and submitted to radiographic investigation for Cobb angle calculation.RESULTS:
It was observed that 14 patients had scoliosis; of these 14 patients, 10 were male. The pattern of deformity in younger patients was that of flexible and simple curves, although adults presented with double and triple curves. Statistical analysis showed no relationships between scoliosis and age or sex.CONCLUSION:
This study revealed a prevalence of scoliosis in patients with Williams-Beuren syndrome of 34.1%; however, age and sex were not significantly associated with scoliosis or with the severity of the curves. 相似文献999.
Patrícia Padrão Milton Severo Albertino Damasceno Carla Silva-Matos António Prista Ana Azevedo 《Annals of human biology》2015,42(2):160-167
Background: Risk factors for cardiovascular diseases tend to cluster, although evidence from settings under epidemiological transition is scarce.Aim: To identify patterns of clustering of cardiovascular risk factors and to quantify their association with sociodemographic characteristics, in Mozambique.Subjects and methods: A national representative sample (n?=?3323) of subjects aged 25–64 years was evaluated in 2005, using the World Health Organization Stepwise Approach to Chronic Disease Risk Factor Surveillance (STEPS). Patterns of joint exposure to high blood pressure, high fasting blood glucose, high body mass index, smoking, excessive alcohol consumption, low fruit/vegetables intake and insufficient physical activity were identified through latent class analysis.Results: Three patterns were identified among women: (1) “healthier”, lower frequency of most risk factors (53.0%); (2) “hypertension-overweight” (21.1%), more frequent among older and urban subjects; and (3) “hypertension-smoking-alcohol” (25.9%), whose frequency increased with age and decreased with education. In men, two clusters were identified: (1) “hypertension-overweight” (30.1%); and (2) “smoking” (69.9%). The frequency of the latter pattern was higher in urban areas and increased with age and education.Conclusion: Hypertension, overweight/obesity, smoking and excessive alcohol intake defined the main clusters of cardiovascular risk factors. This should be considered when planning prevention and control strategies for cardiovascular diseases in Mozambique. 相似文献
1000.
M.V. Damasceno L.A. Pasqua A.E. Lima-Silva R. Bertuzzi 《Brazilian journal of medical and biological research》2015,48(11):1048-1054
This study aimed to verify the association between the contribution of energy systems
during an incremental exercise test (IET), pacing, and performance during a 10-km
running time trial. Thirteen male recreational runners completed an incremental
exercise test on a treadmill to determine the respiratory compensation point (RCP),
maximal oxygen uptake (), peak treadmill speed (PTS), and energy systems contribution; and
a 10-km running time trial (T10-km) to determine endurance performance. The fractions
of the aerobic (WAER) and glycolytic (WGLYCOL) contributions
were calculated for each stage based on the oxygen uptake and the oxygen energy
equivalents derived by blood lactate accumulation, respectively. Total metabolic
demand (WTOTAL) was the sum of these two energy systems. Endurance
performance during the T10-km was moderately correlated with RCP, and PTS (P<@0.05), and moderate-to-highly correlated with
WAER, WGLYCOL, and WTOTAL (P<0.05). In
addition, WAER, WGLYCOL, and WTOTAL were also
significantly correlated with running speed in the middle (P<0.01) and final
(P<0.01) sections of the T10-km. These findings suggest that the assessment of
energy contribution during IET is potentially useful as an alternative variable in
the evaluation of endurance runners, especially because of its relationship with
specific parts of a long-distance race. 相似文献