全文获取类型
收费全文 | 8404篇 |
免费 | 408篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 79篇 |
儿科学 | 153篇 |
妇产科学 | 119篇 |
基础医学 | 1139篇 |
口腔科学 | 274篇 |
临床医学 | 579篇 |
内科学 | 2250篇 |
皮肤病学 | 112篇 |
神经病学 | 483篇 |
特种医学 | 272篇 |
外科学 | 1407篇 |
综合类 | 31篇 |
预防医学 | 232篇 |
眼科学 | 128篇 |
药学 | 585篇 |
中国医学 | 10篇 |
肿瘤学 | 1009篇 |
出版年
2023年 | 58篇 |
2022年 | 129篇 |
2021年 | 210篇 |
2020年 | 105篇 |
2019年 | 161篇 |
2018年 | 175篇 |
2017年 | 132篇 |
2016年 | 146篇 |
2015年 | 156篇 |
2014年 | 195篇 |
2013年 | 234篇 |
2012年 | 358篇 |
2011年 | 396篇 |
2010年 | 218篇 |
2009年 | 187篇 |
2008年 | 347篇 |
2007年 | 373篇 |
2006年 | 301篇 |
2005年 | 348篇 |
2004年 | 335篇 |
2003年 | 318篇 |
2002年 | 320篇 |
2001年 | 314篇 |
2000年 | 279篇 |
1999年 | 255篇 |
1998年 | 108篇 |
1997年 | 72篇 |
1996年 | 81篇 |
1995年 | 67篇 |
1994年 | 62篇 |
1993年 | 68篇 |
1992年 | 238篇 |
1991年 | 215篇 |
1990年 | 203篇 |
1989年 | 210篇 |
1988年 | 167篇 |
1987年 | 162篇 |
1986年 | 172篇 |
1985年 | 122篇 |
1984年 | 95篇 |
1983年 | 95篇 |
1982年 | 52篇 |
1979年 | 64篇 |
1978年 | 53篇 |
1977年 | 44篇 |
1975年 | 40篇 |
1974年 | 50篇 |
1973年 | 47篇 |
1972年 | 45篇 |
1971年 | 40篇 |
排序方式: 共有8862条查询结果,搜索用时 46 毫秒
81.
82.
Tadashi Yasuda Hirokazu Imai Yasushi Nakamoto Akira B. Miura Shiegki Inomata 《Virchows Archiv : an international journal of pathology》1992,421(4):297-303
Summary The pathogenesis of the nodular lesion in diabetic glomerulosclerosis is described in association with fibrils. Thirteen diabetic patients with glomerular nodular lesions and 9 diabetics without the nodules were examined by electron microscopy using periodic acid-thio-carbohydrazide-silver proteinate staining. In cases of nodular glomerulosclerosis, abundant fibrillar structures mixed with electron-dense material were detected within the nodule and the mesangial matrix. They were also occasionally observed along the subendothelial space of the glomerular capillary walls. On the cross-section, these fibrils, including the lucent periphery, were 34 nm wide. Immunohistologically, collagen V and collagen VI were detected in nodular lesions. In contrast, in cases of the diffuse type of glomerulosclerosis, the widened mesangium was composed of dense material, which resembled the original mesangial matrix. The above fibrils were not detected in the mesangium. These findings suggest that the accumulation of the peculiar fibrils in the glomerular mesangium is a major pathogenic factor in the formation of Kimmelstiel-Wilson nodules. 相似文献
83.
Toshikatsu Shimizu Koji Yoshitomi Junichi Taniguchi Masashi Imai 《Pflügers Archiv : European journal of physiology》1989,414(5):500-508
Morphological studies have demonstrated that a chronic increase in distal Na+ delivery causes hypertrophy of the distal convoluted tubule (DCT). To examine whether high NaCl-intake also causes functional changes in the well defined DCT, we measured transmural voltage (V
T), lumen-to-bath Na+ flux (J
Na(LB)), and net K+ secretion (J
K(net)) in DCTs obtained from control rabbits and those on high NaCl-intake diets. The lumen negativeV
T was significantly greater in the high NaCl group than in the control group. The net K+ secretion (pmol mm–1 min–1) was greater in the high NaCl-intake group (54.1±13.0 vs 14.7±5.6). The K+ permeabïlities in both luminal and basolateral DCT membranes, as assessed by the K+-induced transepithelial voltage deflection inhibitable with Ba2+, were increased in the experimental group. The lumen-to-bath22Na flux (pmol mm–1 min–1) was also greater in the experimental group (726±119 vs 396±65). TheV
T component inhibitable with amiloride was also elevated in the high NaCl-intake group. Furthermore, Na+–K+-ATPase activity of the DCT was higher in the experimental than in the control group. We conclude that high NaCl intake increases both Na+ reabsorption and K+ secretion by the DCT. This phenomenon is associated with an increased Na+–K+-ATPase activity along with increased Na+ and K+ permeabilities of the luminal membrane, and an increase in the K+ permeability of the basolateral membrane. Cellular mechanisms underlying these functional changes remain to be established. 相似文献
84.
85.
Katsuhiko Aoyama Kazuo Terashima Yutaka Imai Noriko Katsushima Yoshio Okuyama Katsuhisa Niikawa Takeo Mukada Katsuro Takahashi 《Pathology international》1984,34(2):375-388
The present paper deals with immunohistochemical and ultrastructural study of the lymph nodes of sinus histiocytosis with massive lymphadenopathy (Rosai and Dorfman, SHML) of a 12-year-old Japanese boy. This is the fourth case in Japan. Osseous manifestation was also found in the bilateral ulnae. With hallmarks of S-100 protein and interdigitating cytoplasmic extensions, the phagocytizing histiocytes proliferating in the sinuses were considered to be derived mostly from interdigitating cells in the paracortex or T cell dependent area, which have heretofore been regarded as nonphagocytizing. Furthermore, it is most interesting that lymphoid cells bearing thymic cortical cell-antigen (OKT 6) were increasingly recognized in the patient's peripheral blood. These results suggested that SHML is a specialized reactive histiocytosis analogous to histiocytosis X and histiocytic medullary reticulosis. 相似文献
86.
Masaru Enomoto Akihiro Tamori Madoka Toyama Kohmoto Takehiro Hayashi Hisato Jomura Daiki Habu Hiroki Sakaguchi Tadashi Takeda Norifumi Kawada Shuichi Seki Susumu Shiomi Noritoshi Koh Shuhei Nishiguchi 《Journal of interferon & cytokine research》2007,27(3):201-207
Sequential treatment with lamivudine and interferon (IFN) has induced sustained biochemical and virologic responses in the majority of patients with chronic hepatitis B in France. However, the efficacy of sequential treatment in patients with chronic hepatitis B virus (HBV) genotype C infection has not been evaluated. Twenty-four HBe antigen-positive patients were treated with 100 mg lamivudine alone for 16-32 weeks, then with both 6 MU IFN-beta and lamivudine for 4 weeks, and lastly with IFN-beta alone for 20 weeks. Sustained response was achieved in 7 (29%) patients 24 weeks after the end of therapy. No lamivudine-resistant variants emerged in any patient. Hepatitis flare occurred in 3 patients after the withdrawal of lamivudine, but none had decompensation. The patients with sustained response were significantly younger at baseline (p = 0.033) and had a significantly lower HBV DNA level at the start of IFN (p = 0.020) than those without sustained response. In conclusion, the rate of response to sequential therapy with lamivudine and IFN in HBe antigen-positive patients with HBV genotype C infection was lower than the rate reported previously. Patients who were young or who had a favorable virologic response to lamivudine were more likely to have a sustained response. 相似文献
87.
Shunsuke Imai Susumu Sekigawa Hiroaki Yamamoto Yoshihiko Tsubura Michiyo Miyanaga Nobuhiro Narita Riichiro Mikami 《Pathology international》1982,32(4):677-682
An autopsy case of bronchiolo-alveolar adenocarcinoma in the lung is reported. The patient is a 70-year-old male who complained of severe cough with 500–600 ml watery sputum a day, loss of weight, and general fatigue. Autopsy revealed numerous whitish tumors in various sizes with multiple cysts in both lungs, with no metastasis being found in any other organs. Histological findings identified the tumor as a bronchiolo-alveolar adenocarcinoma originating from the lungs. Electron-microscopic findings showed that the tumor cells were covered by prominent microvilli, and contained abundant irregulary-shaped cytoplasmic vacuoles suggestive of mucin. 相似文献
88.
K Terashima K Takahashi M Kojima Y Imai S Tsuchida S Migita S Ebina C Itoh 《Acta pathologica japonica》1978,28(1):111-138
An autopsy case of systemic histiocytosis with excessive deposition of kappa-type light chain crystals was reported in a 58 year-old man who had consistently showed kappa-type light chain paraproteinemia, Bence Jones proteinuria and hypogammaglobulinemia for about 10 years until his death. However, no bony destruction was found by repeated X-ray examinations. At autopsy, extensive hyperplasia of crystal-storing histiocytes was observed in the bone marrow, spleen, liver, lymph nodes, interstitial tissues of visceral organs and loose connective tissues. In the bone marrow and some other tissues, mild proliferation of plasmocytoid cells containing small crystals were found. Histochemically the crystals positively stained with various methods for amino acids and proteins, especially with Weigerts' method for fibrin. Ultrastructurally intralysosomal crystal deposition was confirmed in the storage histiocytes and derivation of the crystals from Golgi's sacculi in the plasmocytoid cells was suggested. Biochemically the crystals were regarded as mainly consisting of dimers of a variable half of light chain immunoglobulin and immunochemically and immunohistochemically reacted to anti-kappa type light chain serum. Such a generalized storage histiocytosis may be secondarily induced by immunoglobulin synthesized in plasmocytoid cells. 相似文献
89.
BACKGROUND: In Asian countries, there is no epidemiological report on seasonal affective disorder (SAD) in different age groups and different geographic regions surveyed at the same time. The aim of this study was to estimate the prevalence rates of SAD and risk factors for SAD in adults and high-school students, with special reference to the difference of winter SAD between northern and southern regions in Japan. METHODS: A total of 3237 high-school students and 4858 workers living in Japan (31.3-43.5 degrees N) responded to this epidemiological survey using Japanese version of the Seasonal Pattern Assessment Questionnaire (SPAQ). RESULTS: The overall prevalence rates of winter SAD (subsyndromal winter SAD) and summer SAD (subsyndromal summer SAD) in high-school students were 0.91(2.21) and 0.81(2.57)%, respectively. In workers, these rates were 0.45(1.16) and 0.43(0.71)%, respectively. Although no regional difference was noted in high-school students with winter seasonal type, the estimated odds ratio of this type for northern workers was nearly 3-fold higher than the southern counterparts. The prevalence rates of each seasonal type were not significantly different between two sexes in both age groups. No clear dependence on latitude was seen with regard to summer SAD in both age groups. LIMITATIONS: The effect of climate on SAD could not be entirely excluded from geophysical factor as indexed by latitude. CONCLUSIONS: SAD was less common in adults than in high-school students. While latitude was a major determinant of winter type in adults, socio-cultural factors or other contributing factors might affect the development of this type in high-school students. 相似文献
90.
Tatsuo Yamazaki Shigeki Tomita Kazuhito Ichikawa Yuko Ono Fujiyuki Inaba Ichio Fukasawa Yasuo Imai Johji Imura Hirokazu Fukui Takahiro Fujimori Noriyuki Inaba 《Pathobiology》2006,73(4):176-182
OBJECTIVES: We investigated the relationship between P16-immunostaining patterns and clinicopathological factors in early uterine cervix cancers and assessed whether P16-immunostaining patterns predict the prognosis of the patients with early uterine cervix cancers. METHODS: Twenty-nine early squamous cell carcinoma (SCC) specimens of the uterus were examined using immunohistochemistry for P16 expression. The P16-immunostaining pattern was classified into two groups: the homogeneous type and the heterogeneous type. P16-immunostaining patterns were evaluated in different parts of the carcinoma in situ (CIS): the center of the tumor and the front interface of the infiltrating tumor. RESULTS: All specimens were of the homogeneous type in CIS. The P16-immunostaining pattern was significantly of the heterogeneous type in the front interface of the infiltrating tumor with lymphatic invasion, vascular invasion, lymph node metastasis, and recurrence. Regarding the P16-immunostaining patterns in the front interface of the infiltrating tumor, the patients with the heterogeneous type showed a significantly worse prognosis than the patients with the homogeneous type. CONCLUSIONS: The prognosis of patients with early uterine cervical SCC may be predicted by evaluating the P16-immunostaining pattern in the front interface of the infiltrating tumor. 相似文献