全文获取类型
收费全文 | 7450篇 |
免费 | 643篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 229篇 |
妇产科学 | 118篇 |
基础医学 | 973篇 |
口腔科学 | 257篇 |
临床医学 | 677篇 |
内科学 | 1515篇 |
皮肤病学 | 166篇 |
神经病学 | 612篇 |
特种医学 | 396篇 |
外国民族医学 | 1篇 |
外科学 | 1002篇 |
综合类 | 71篇 |
预防医学 | 534篇 |
眼科学 | 145篇 |
药学 | 461篇 |
中国医学 | 28篇 |
肿瘤学 | 836篇 |
出版年
2023年 | 33篇 |
2022年 | 78篇 |
2021年 | 181篇 |
2020年 | 110篇 |
2019年 | 221篇 |
2018年 | 249篇 |
2017年 | 175篇 |
2016年 | 182篇 |
2015年 | 219篇 |
2014年 | 283篇 |
2013年 | 321篇 |
2012年 | 389篇 |
2011年 | 420篇 |
2010年 | 267篇 |
2009年 | 232篇 |
2008年 | 355篇 |
2007年 | 346篇 |
2006年 | 307篇 |
2005年 | 305篇 |
2004年 | 281篇 |
2003年 | 254篇 |
2002年 | 232篇 |
2001年 | 194篇 |
2000年 | 220篇 |
1999年 | 176篇 |
1998年 | 106篇 |
1997年 | 101篇 |
1996年 | 82篇 |
1995年 | 83篇 |
1994年 | 71篇 |
1993年 | 81篇 |
1992年 | 128篇 |
1991年 | 135篇 |
1990年 | 117篇 |
1989年 | 141篇 |
1988年 | 103篇 |
1987年 | 126篇 |
1986年 | 91篇 |
1985年 | 69篇 |
1984年 | 67篇 |
1983年 | 41篇 |
1982年 | 49篇 |
1981年 | 57篇 |
1980年 | 43篇 |
1979年 | 54篇 |
1978年 | 25篇 |
1977年 | 39篇 |
1976年 | 52篇 |
1975年 | 27篇 |
1971年 | 28篇 |
排序方式: 共有8131条查询结果,搜索用时 15 毫秒
11.
To incorporate family therapy into an inpatient treatment program for spinal cord injured substance abusers required overcoming both staff and patient resistance. Since it became an integral part of the program, family therapy has shown itself to be helpful in dealing with this population's tendency to adapt to their injury either by overdependency or overachievement. Its usefulness to patients with other chronic disabilities appears to warrant consideration. 相似文献
12.
13.
14.
Acute epidural hematoma: an analysis of factors influencing the outcome of patients undergoing surgery in coma 总被引:4,自引:0,他引:4
R D Lobato J J Rivas F Cordobes E Alted C Perez R Sarabia A Cabrera I Diez P Gomez E Lamas 《Journal of neurosurgery》1988,68(1):48-57
Mortality due to epidural hematoma is virtually restricted to patients who undergo surgery for that condition while in coma. The authors have analyzed the factors influencing the outcome of 64 patients who underwent epidural hematoma evacuation while in coma. These patients represented 41% of the 156 patients operated on for epidural hematoma at their centers after the introduction of computerized tomography (CT). Eighteen patients (28.1%) died, two (3.1%) became severely disabled, and 44 (68.8%) made a functional recovery. The mortality rate for the entire series was 12%, significantly lower than the 30% rate observed when only angiographic studies were available. A significant correlation was found between the final result and the mechanism of injury, the interval between trauma and surgery, the motor score at operation, the hematoma CT density (homogeneous vs. heterogeneous), and the hematoma volume. The patient's age, the course of consciousness before operation (whether there was a lucid interval), and the clot location did not correlate with the final outcome. The mortality rate was significantly higher in patients operated on within 6 hours or between 6 and 12 hours after injury than in those undergoing surgery 12 to 48 hours after injury. Compared with the patients operated on later, the patients undergoing surgery in the early period were, on the average, older and had more rapidly developing symptoms, more pupillary changes, lower motor scores at surgery, larger hematomas, a higher incidence of mixed CT density clots, more severe associated intracranial lesions, and higher postoperative intracranial pressure (ICP). The mechanism of trauma seems to influence the course of consciousness before and after surgery. Passengers injured in traffic accidents had a lower incidence of a lucid interval and longer postoperative coma than patients with low-speed trauma, suggesting more frequent association of diffuse white matter-shearing injury. The duration of postoperative coma correlated with the morbidity rate in survivors. Forty-eight patients (75%) had one or more associated intracranial lesions, and 70% of these required treatment for elevation of ICP after hematoma evacuation. An ICP of over 35 mm Hg strongly correlated with poor outcome; administration of high-dose barbiturates was the only effective means for lowering ICP in nine of 15 patients who developed severe intracranial hypertension after surgery. This study attempts to identify patients at greater risk for presenting postoperative complications and to define a strategy for control CT scanning and ICP monitoring. 相似文献
15.
Carcinoma of the hepaticopancreatic ampullar region: role of US 总被引:3,自引:0,他引:3
Hepaticopancreatic ampullar tumors are so called because they are located at the confluence of the bile duct, pancreatic duct, and duodenum. Jaundice is an early sign of the disease and often leads to early diagnosis and favorable prognosis compared with other tumors that occur in this area. Of eight patients who underwent ultrasound (US) in the past 5 years, six (75%) were found to have tumor. The sizes of the tumors ranged from 1.6 to 2 cm. An intraluminal, polypoid mass in the distal part of the common bile duct was seen in four patients. In the other two patients, a sharply delineated mass gave rise to abrupt termination of the distal duct. Improved US resolution, more experience with this modality, and accurate diagnosis of these tumors with US will contribute to improved detection and prompt treatment. 相似文献
16.
Paget's disease primarily involving the scrotum 总被引:16,自引:0,他引:16
Three cases of Paget's disease primarily involving the scrotum are reported. One case exhibited positive staining for prostate specific antigen (PSA) and was associated with an underlying, invasive poorly differentiated adenocarcinoma of unknown primary. The other cases were not associated with any underlying or visceral malignancy. The literature on Paget's disease primarily involving the scrotum including clinical presentation, differential diagnosis, treatment, prognosis, and possible histogenetic mechanisms of this disease is discussed. 相似文献
17.
Diarrheal diseases have a well recognized negative effect on children's growth, probably due in part to reduced dietary intake during illness. Previous studies have shown that the effects of diarrhea on dietary intake are greater among hospitalized children than among those observed in their homes. Breast milk intake does not change during diarrhea, however, so breast-fed children are less likely to reduce their total energy and nutrient intakes. Recent analyses of clinical studies found that acidosis and dehydration were most closely associated with reduced dietary intake of hospitalized patients. The implications of these and other studies for the dietary management of patients during and after diarrhea are discussed. 相似文献
18.
Alicia Bas Ignacio Lopez Jose Perez Mariano Rodriguez Escolastico Aguilera-Tejero 《Journal of bone and mineral research》2006,21(3):484-490
VC is an important clinical entity; however, very little information is available on its resolution. Induction and regression of calcitriol-induced VC was studied in 47 rats. After calcitriol withdrawal, there was a relatively rapid regression of VC mediated by an active cellular process. INTRODUCTION: Vascular calcifications (VCs) represent an important risk factor for cardiovascular death. Although VCs are prevalent in relevant diseases (e.g., chronic kidney disease, osteoporosis, diabetes), the reversibility of extraskeletal calcifications is an unresolved issue. This study was conducted to investigate (1) the in vivo effect of calcitriol on VC and (2) whether calcitriol-induced VC would regress after suppression of calcitriol treatment. MATERIALS AND METHODS: The calcifying effect of calcitriol was studied in four groups of rats (n = 8) that received calcitriol (1 mug/kg, IP) for 2, 4, 6, and 8 days. The reversibility of VC was studied in three additional groups (n = 5) treated with 1 mug/kg of calcitriol for 8 days that were subsequently killed 1, 2, and 9 weeks after the last calcitriol dose. Aortic VC was assessed by histology and by quantification of aortic calcium and phosphorus content. The aortic wall was studied by histology and immunohistochemistry. Statistical analysis was performed by ANOVA and t-tests. RESULTS: Calcitriol administration resulted in a time-dependent induction of VC, with aortic calcium and phosphorus being significantly increased at 6 and 8 days. Treatment with calcitriol for 8 days resulted in massive medial calcification of the aorta with a 10- to 30-fold increase in the aortic Ca and P content. After suppressing calcitriol administration, a progressive decrease in von Kossa staining and aortic Ca (from 32.8 +/- 2.5 to 9.3 +/- 1.8 mg/g of tissue, p < 0.001) and P (from 11.9 +/- 1.2 to 2.7 +/- 1.8 mg/g of tissue, p = 0.001) content was evidenced. Histology of the aortic wall showed monocytes adhered to the aortic endothelium and macrophages involved in the reabsorption of calcium deposits. CONCLUSIONS: Our results show that calcitriol treatment induces time-dependent VC. After calcitriol withdrawal, VC regress rapidly with aortic calcium and phosphorus decreasing by 75% in the course of 9 weeks. An active cellular process seems to be involved in regression of VC. 相似文献
19.
DR Foster 《Journal of Medical Imaging and Radiation Oncology》1995,39(4):399-400
The use of self-expanding prostheses in the management of malignant oesophageal strictures has become well established. The majority of benign peptic oesophageal strictures can be successfully managed using endoscopic or fluoroscopically guided balloon oesophageal dilatation combined with long-term drug therapy, particularly using proton pumper inhibitors. Although endoscopic oesophageal dilatation can be performed on an outpatient basis, it requires repeated hospital visits. There is a small risk of oesophageal perforation whilst cardio-respiratory complications may be encountered during the use of intravenous sedation in an elderly population. The use of a self-expanding Strecker stent in a 98 year old woman with a benign oesophageal stricture is described. 相似文献
20.
I Wacks J R Oster D Roth M Norenberg L B Gardner G O Perez G Burke M Milgrom 《Clinical nephrology》1992,37(1):19-22
We describe a woman whose fatal post-liver transplantation cerebral edema was unexpected and of unusual pathogenesis. Her severe cerebral edema is of considerable pathophysiologic interest: 1) it developed in the setting of marked anasarca and persistent hypernatremia, and 2) although hepatic function was poor, it was not considered sufficiently deranged to induce cerebral edema. Furthermore, there was no histologic evidence of hepatic rejection or antemortem hepatic necrosis. We postulate that an impairment of the blood brain barrier in association with a degree of hepatic dysfunction insufficient by itself to cause cerebral edema permitted the brain interstitial fluid volume to increase pari passu with ECF expansion. Cytotoxic cerebral edema and vascular engorgement may also have contributed to a life-threatening increase in intracranial pressure. 相似文献