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71.
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Combined anticoagulant and antiselectin treatments prevent lethal intravascular coagulation 下载免费PDF全文
Norman KE Cotter MJ Stewart JB Abbitt KB Ali M Wagner BE Wallace WA Forlow SB Hellewell PG 《Blood》2003,101(3):921-928
Widespread microvascular injury followed by vessel obstruction may lead to disseminated intravascular coagulation (DIC). We describe a murine model wherein leukocytes interacting with inflamed microvessels in vivo are activated by antibodies. Treatment of tumor necrosis factor alpha (TNF-alpha)-primed mice with anti-Ly-6G antibodies reproduced many of the features of septic or traumatic shock including microvessel obstruction and coagulation, severe vasculitis, respiratory difficulties, and vascular leakage. Mice lacking either E-selectin or P-selectin were protected from this reaction as were animals treated with a combination of either selectin-blocking antibodies and heparin or a selectin antagonist plus heparin. Combined blockade of leukocyte/platelet adhesion and coagulation may provide convincing protection in DIC. 相似文献
73.
Abidov A Kaluski E Hod H Leor J Vered Z Gottlieb S Behar S Cotter G;Israel Working Group on Intensive Cardiac Care 《The American journal of cardiology》2004,93(1):76-80
Right bundle branch block and complete atrioventricular (AV) block are conduction disorders (CDs) that have been observed in 14% of patients admitted with ST-elevation acute myocardial infarction. CDs carry a poor prognosis, with a threefold increase in the mortality rate, mainly due to cardiogenic shock and recurrent fatal myocardial infarction at 1-year follow-up. According to multivariable analysis, CD was the second strongest predictor of death, after high Killip class. Compared with patients without CD, the 1-year outcome of patients with CD was identically worse, irrespective of whether CD appeared during admission, disappeared, or remained constant. Similar adverse outcomes were seen in patients with complete AV block and right bundle branch block. 相似文献
74.
Cotter SM Sansom S Long T Koch E Kellerman S Smith F Averhoff F Bell BP 《The Journal of infectious diseases》2003,187(8):1235-1240
Between November 1998 and May 1999, 136 cases of hepatitis A were reported in Columbus, Ohio. Eighty-nine (65%) case patients were reinterviewed. Of 74 male case patients, 47 (66%) were men who have sex with men (MSM). These 47 MSM were compared with 88 MSM control subjects, to identify risk factors for infection and potential opportunities for vaccination. During the exposure period, 6 (13%) case patients reported contact with a person who had hepatitis A, compared with 2 (2%) control subjects (odds ratio, 6.15; 95% confidence interval, 1.04-48.02); neither number of sex partners nor any sex practice was associated with illness. Most case patients and control subjects (68% and 77%, respectively) saw a health care provider at least annually, and 93% of control subjects reported a willingness to receive hepatitis A vaccine. MSM are accessible and amenable to vaccination; increased efforts are needed to provide vaccination, regardless of reported sex practices. 相似文献
75.
Comparison of dobutamine stress echocardiography with and without real-time perfusion imaging for detection of coronary artery disease 总被引:2,自引:0,他引:2
Xie F Tsutsui JM McGrain AC Demaria A Cotter B Becher H Lebleu C Labovitz A Picard MH O'Leary EL Porter TR 《The American journal of cardiology》2005,96(4):506-511
In a pilot study of 27 patients, those who presented with chest pain underwent 2 dobutamine stress echocardiographic studies, 1 with high mechanical index harmonic imaging to analyze wall motion without contrast and 1 with real-time low mechanical index perfusion imaging with intravenous Optison to assess myocardial perfusion and wall motion. All patients then underwent quantitative coronary angiography. Two independent reviewers demonstrated an improvement in sensitivity when analyzing myocardial perfusion. In the 21 patients who had significant coronary stenoses, 14 had abnormal myocardial perfusion detected at peak stress and 7 had abnormal wall motion detected by standard dobutamine stress echocardiography. There was decreased specificity with perfusion imaging by 1 reviewer. The addition of real-time perfusion imaging after intravenous contrast during dobutamine stress echocardiography has the potential to improve detection of coronary artery disease. 相似文献
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Solomon Aragie Sintayehu Gebresillasie Ambahun Chernet Ayalew Shiferaw Zerihun Tadesse Mulat Zerihun Nicole E. Varnado Sun Y. Cotter Dionna M. Wittberg Zhaoxia Zhou Elizabeth Kelly Callahan Scott D. Nash Kristen Aiemjoy Jeremy D. Keenan 《The American journal of tropical medicine and hygiene》2021,104(4):1271
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Summary Aldose reductase inhibitors (ARIs) attenuate diabetic complications in several tissues, including lens, retina, kidney, blood
vessels, striated muscle and peripheral nerve. However, it is unclear whether their action in diabetes mellitus depends directly
on inhibiting the conversion of glucose to sorbitol by aldose reductase or indirectly by reducing the sorbitol available for
subsequent metabolism to fructose by sorbitol dehydrogenase. To identify the polyol pathway step most relevant to complications,
particularly neuropathy, we compared the biochemical effects of a sorbitol dehydrogenase inhibitor, WAY-135 706, (250 mg ·
kg−1· day−1) and an ARI, WAY-121 509, (10 mg · kg−1· day−1) on a variety of tissues, and their effects on nerve perfusion and conduction velocity. After 6 weeks of untreated streptozotocin
diabetes, rats were treated for 2 weeks. Sorbitol was elevated 2.1–32.6-fold by diabetes in lens, retina, kidney, aorta, diaphragm,
erythrocytes and sciatic nerve; this was further increased (1.6–8.2-fold) by WAY-135 706 whereas WAY-121 509 caused a marked
reduction. Fructose 1.6–8.0-fold elevated by diabetes in tissues other than diaphragm, was reduced by WAY-135 706 and WAY-121
509, except in the kidney. Motor and sensory nerve conduction velocities were decreased by 20.2 and 13.9 %, respectively with
diabetes. These deficits were corrected by WAY-121 509, but WAY-135 706 was completely ineffective. A 48.6 % diabetes-induced
deficit in sciatic nutritive endoneurial blood flow was corrected by WAY-121 509, but was unaltered by WAY-135 706. Thus,
despite profound sorbitol dehydrogenase inhibition, WAY-135 706 had no beneficial effect on nerve function. The data demonstrate
that aldose reductase activity, the first step in the polyol pathway, makes a markedly greater contribution to the aetiology
of diabetic neurovascular and neurological dysfunction than does the second step involving sorbitol dehydrogenase. [Diabetologia
(1997) 40: 271–281]
Received: 13 August 1996 and in final revised form: 6 December 1996 相似文献