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排序方式: 共有452条查询结果,搜索用时 25 毫秒
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Rogelio A. Coronado Payton E. Robinette Abigail L. Henry Jacquelyn S. Pennings Christine M. Haug Richard L. Skolasky Lee H. Riley Brian J. Neuman Joseph S. Cheng Oran S. Aaronson Clinton J. Devin Stephen T. Wegener Kristin R. Archer 《The spine journal》2021,21(1):55-63
BACKGROUND CONTEXTPositive psychosocial factors early after surgery, such as resilience and self-efficacy, may be important characteristics for informing individualized postoperative care.PURPOSETo examine the association of early postoperative resilience and self-efficacy on 12-month physical function, pain interference, social participation, disability, pain intensity, and physical activity after lumbar spine surgery.STUDY DESIGN/SETTINGPooled secondary analysis of prospectively collected trial data from two academic medical centers.PATIENT SAMPLETwo hundred and forty-eight patients who underwent laminectomy with or without fusion for a degenerative lumbar condition.OUTCOME MEASURESPhysical function, pain inference, and social participation (ability to participate in social roles and activities) were measured using the Patient Reported Outcomes Measurement Information System. The Oswestry Disability Index, Numeric Rating Scale, and accelerometer activity counts were used to measure disability, pain intensity, and physical activity, respectively.METHODSParticipants completed validated outcome questionnaires at 6 weeks (baseline) and 12 months after surgery. Baseline positive psychosocial factors included resilience (Brief Resilience Scale) and self-efficacy (Pain Self-Efficacy Questionnaire). Multivariable linear regression analyses were used to assess the associations between early postoperative psychosocial factors and 12-month outcomes adjusting for age, sex, study site, randomized group, fusion status, fear of movement (Tampa Scale for Kinesiophobia), and outcome score at baseline. This study was funded by Patient-Centered Outcomes Research Institute and Foundation for Physical Therapy Research. There are no conflicts of interest.RESULTSResilience at 6 weeks after surgery was associated with 12-month physical function (unstandardized beta=1.85 [95% confidence interval [CI]: 0.29; 3.40]), pain interference (unstandardized beta=?1.80 [95% CI: ?3.48; ?0.12]), social participation (unstandardized beta=2.69 [95% CI: 0.97; 4.41]), and disability (unstandardized beta=?3.03 [95% CI: ?6.04; ?0.02]). Self-efficacy was associated with 12-month disability (unstandardized beta=?0.21 [95% CI: ?0.37; ?0.04].CONCLUSIONSPostoperative resilience and pain self-efficacy were associated with improved 12-month patient-reported outcomes after spine surgery. Future work should consider how early postoperative screening for positive psychosocial characteristics can enhance risk stratification and targeted rehabilitation management in patients undergoing spine surgery. 相似文献
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VG Stuttgart 《MedR Medizinrecht》2000,18(6):277-278
Ohne Zusammenfassung 相似文献
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Esther Coronado Yania Yaez Enrique Vidal Luis Rubio Francisco VeraSempere Antonio Jos CaadaMartínez Joaquín Panadero Adela Caete Ruth Ladenstein Victoria Castel Jaime Font de Mora 《Molecular oncology》2021,15(2):364
High‐risk neuroblastoma (NB) patients with 11q deletion frequently undergo late but consecutive relapse cycles with fatal outcome. To date, no actionable targets to improve current multimodal treatment have been identified. We analyzed immune microenvironment and genetic profiles of high‐risk NB correlating with 11q immune status. We show in two independent cohorts that 11q‐deleted NB exhibits various immune inhibitory mechanisms, including increased CD4+ resting T cells and M2 macrophages, higher expression of programmed death‐ligand 1, interleukin‐10, transforming growth factor‐beta‐1, and indoleamine 2,3‐dioxygenase 1 (P < 0.05), and also higher chromosomal breakages (P ≤ 0.02) and hemizygosity of immunosuppressive miRNAs than MYCN‐amplified and other 11q‐nondeleted high‐risk NB. We also analyzed benefits of maintenance treatment in 83 high‐risk stage M NB patients focusing on 11q status, either with standard anti‐GD2 immunotherapy (n = 50) or previous retinoic acid‐based therapy alone (n = 33). Immunotherapy associated with higher EFS (50 vs. 30, P = 0.028) and OS (72 vs. 52, P = 0.047) at 3 years in the overall population. Despite benefits from standard anti‐GD2 immunotherapy in high‐risk NB patients, those with 11q deletion still face poor outcome. This NB subgroup displays intratumoral immune suppression profiles, revealing a potential therapeutic strategy with combination immunotherapy to circumvent this immune checkpoint blockade.
Abbreviations
- 11q‐del
- 11q‐deleted
- ADCC
- antibody‐dependent cellular cytotoxicity
- CDC
- complement‐dependent cytotoxicity
- COJEC
- chemotherapeutic agents cisplatin, vincristine, carboplatin, etoposide, and cyclophosphamide
- CTLA‐4
- cytotoxic T lymphocyte antigen 4
- EFS
- event‐free survival
- FISH
- fluorescence in situ hybridization
- HR
- hazard ratio
- ICI
- immune checkpoint inhibitor
- IDO1
- indoleamine 2,3‐dioxygenase 1
- IFN‐γ
- interferon‐γ
- IL‐10
- interleukin 10
- INRG
- International Neuroblastoma Risk Group
- miR
- microRNA
- MLPA
- multiplex ligation‐dependent probe amplification
- MMR
- mismatch repair
- MNA
- MYCN amplification
- MS
- metastatic special stage
- MSI
- microsatellite instability
- NB
- neuroblastoma
- NCA
- numerical chromosome aberrations
- NOS
- nitric oxide synthase
- OS
- overall survival
- PD‐1
- programmed cell death protein 1
- PD‐L1
- programmed death‐ligand 1
- SCA
- segmental chromosome aberrations
- TAM
- tumor‐associated macrophages
- Tfh
- follicular helper T cells
- TGF‐β
- tumor growth factor‐β
- TMB
- tumor mutational burden
- TME
- tumor microenvironment
- TNF‐α
- tumor necrosis factor‐α
- Treg
- regulatory T cells
90.
Manuel Duárez Coronado Nuria Izquierdo MéndezMiguel Ángel Herraiz Martínez José Antonio Vidart Aragón 《Progresos de Obstetricia y Ginecología》2013
Eclampsia, a clinical syndrome classically defined by the occurrence of seizures and/or coma in pregnant women with hypertension and proteinuria, is often presented as a posterior reversible encephalopathy syndrome (PRES), a clinical-radiological entity characterized by headache, visual disturbances, seizures and/or alteration of consciousness, besides a radiological pattern of reversible vasogenic cerebral edema located in posterior territory. 相似文献