Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome

A possible protective effect of vitamin E (DL-alpha-tocopherol) on chromosomal damage was evaluated in lymphocytes from patients with Down's syndrome (DS) and from controls. This included the analysis of the basal and G2 chromosomal aberration frequencies in lymphocytes cultured with and without 100 microM vitamin E. The chromosomal damage in G2 was determined by scoring the number of chromosomal aberrations in lymphocyte cultures treated with 5 mM caffeine, 2 h before harvesting. Vitamin E treatment decreased the basal and G2 chromosomal aberrations both in control and DS lymphocytes. In DS cells, this protective effect, expressed as a decrease in the chromosomal damage, was greater (50%) than in controls (30%). These results suggest that the increment in basal and G2 aberrations yield in DS lymphocytes may be related to the increase in oxidative damage reported in these patients.     

Claeys MJ,Bosmans JM,Hendrix J,Vrints CJ. Reliability of fractional flow reserve measurements in patients with associated microvascular dysfunction: Importance of flow on translesional pressure gradient. Cathet Cardiovasc Intervent 2001;54:427–434

The original article to which this Erratum refers was published in Catheterization and Cardiovascular Interventions; 2002; 54(4) 427–434     

广西藤茶中黄酮类成份的提取工艺研究

目的：提取分离藤（Ａｍｐｅｌｏｓｉｓ ｇｒｏｓｓｄｅｎｔａｔａ）中的双氢杨梅树皮素（ｄｉｈｙｄｒｏｍｙｒｉｃｅｔｉｎ）和杨梅素（Ｍｙｒｉｃｅｔｉｎ）。方法：采用新的水提取和溶剂分离的方法,经化学和光谱鉴定确定结构。结果：提取产物经确证为双氢杨梅树皮素（ｄｉｈｙｄｒｏｍｙｒｉｃｅｔｉｎ）和杨梅素（Ｍｙｒｉｃｅｔｉｎ）,平均收率分别为１９．６％和０．５１％。结论：该提取法经济、简便,易于操作并且提取率     

A review of ultrasound-guided percutaneous biopsy of the gastrointestinal tract in HIV-infected patients

Objective To illustrate the use of percutaneous ultrasound-guided biopsy of the gastrointestinal tract in HIV-infected patients to obtain a tissue diagnosis.
Design The technique was used in relation to relevant clinical situations in which a diagnosis may have only been reached by open biopsy.
Method Three HIV-infected patients with suspected gastrointestinal tract lesions underwent percutaneous ultrasound-guided biopsy under local anaesthetic.
Results A tissue diagnosis was made in each case resulting in initiation or continuation of appropriate therapy and avoided the need for open biopsy under general anaesthetic.
Conclusion Although the number of patients undergoing the procedure in this series was small, the technique has so far been shown to be safe and effective with few complications.