全文获取类型
收费全文 | 3485篇 |
免费 | 188篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 146篇 |
儿科学 | 95篇 |
妇产科学 | 70篇 |
基础医学 | 375篇 |
口腔科学 | 90篇 |
临床医学 | 435篇 |
内科学 | 533篇 |
皮肤病学 | 59篇 |
神经病学 | 242篇 |
特种医学 | 222篇 |
外科学 | 297篇 |
综合类 | 324篇 |
预防医学 | 272篇 |
眼科学 | 53篇 |
药学 | 265篇 |
3篇 | |
中国医学 | 99篇 |
肿瘤学 | 144篇 |
出版年
2022年 | 28篇 |
2021年 | 55篇 |
2020年 | 53篇 |
2019年 | 45篇 |
2018年 | 38篇 |
2017年 | 49篇 |
2016年 | 38篇 |
2015年 | 62篇 |
2014年 | 81篇 |
2013年 | 103篇 |
2012年 | 171篇 |
2011年 | 165篇 |
2010年 | 120篇 |
2009年 | 115篇 |
2008年 | 165篇 |
2007年 | 165篇 |
2006年 | 164篇 |
2005年 | 139篇 |
2004年 | 105篇 |
2003年 | 104篇 |
2002年 | 82篇 |
2001年 | 96篇 |
2000年 | 82篇 |
1999年 | 79篇 |
1998年 | 47篇 |
1997年 | 57篇 |
1996年 | 56篇 |
1995年 | 47篇 |
1994年 | 54篇 |
1993年 | 38篇 |
1992年 | 32篇 |
1991年 | 46篇 |
1990年 | 50篇 |
1989年 | 40篇 |
1988年 | 44篇 |
1987年 | 48篇 |
1986年 | 35篇 |
1985年 | 49篇 |
1984年 | 40篇 |
1983年 | 29篇 |
1980年 | 20篇 |
1979年 | 31篇 |
1977年 | 23篇 |
1975年 | 20篇 |
1959年 | 41篇 |
1958年 | 66篇 |
1957年 | 76篇 |
1956年 | 73篇 |
1955年 | 83篇 |
1954年 | 52篇 |
排序方式: 共有3724条查询结果,搜索用时 984 毫秒
71.
M. RIGHINI G. LE GAL D. AUJESKY P.‐M. ROY O. SANCHEZ F. VERSCHUREN O. T. RUTSCHMANN T. PERNEGER A. PERRIER 《Journal of thrombosis and haemostasis》2012,10(3):347-351
Summary. Background: A pulmonary embolism (PE) is thought to be associated with atrial fibrillation (AF). Nevertheless, this association is based on weak data. Objectives: To assess whether the presence of AF influences the clinical probability of PE in a cohort of patients with suspected PE and to confirm the association between PE and AF. Patients/methods: We retrospectively analyzed the data from two trials that included 2449 consecutive patients admitted for a clinically suspected PE. An electrocardiography (ECG) was systematically performed and a PE was diagnosed by computer tomography (CT). The prevalence of AF among patients with or without a PE was compared in a multivariate logistic regression model. Results: The prevalence of PE was 22.8% (519/2272) in patients without AF and 18.8% (25/133) in patients with AF (P = 0.28). After adjustment for confounding factors, AF did not significantly modify the probability of PE (odds ratio [OR] 0.68, 95% confidence interval [CI] 0.42–1.11). However, when PE suspicion was based on new‐onset dyspnea, AF significantly decreased the probability of PE (OR 0.47, 95% CI 0.26–0.84). If isolated chest pain without dyspnea was the presenting complaint, AF tended to increase the probability of PE (OR 2.42, 95% CI 0.97–6.07). Conclusions: Overall, the presence of AF does not increase the probability of PE when this diagnosis is suspected. Nevertheless, when PE suspicion is based on new‐onset dyspnea, AF significantly decreases the probability of PE, as AF may mimic its clinical presentation. However, in patients with chest pain alone, AF tends to increase PE probability. 相似文献
72.
Chronic airway inflammation provides a unique environment for B cell activation and antibody production
下载免费PDF全文
![点击此处可从《Clinical and experimental allergy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
73.
74.
C. BIGORGNE A. LE TOURNEAU B. MESSING B. RIO V. GIRAUD T. MOLINA J. AUDOUIN & J. DIEBOLD 《British journal of haematology》1996,95(2):258-262
Bone marrow examination revealed a lipid-laden histiocytosis in seven patients undergoing long-term total parenteral nutrition necessitated by extensive short-bowel surgical resection. Clinical abnormalities occurred during this treatment which required bone marrow examination. These included hepatosplenomegaly and peripheral blood cytopenia; the median time to the detection of these abnormalities was 64 months. The most striking change within the bone marrow was the presence of many pigment-laden histiocytes which had the typical morphology of sea-blue histiocytes seen in the so-called idiopathic sea-blue histiocyte syndrome. The occurrence of sea-blue histiocytosis in the bone marrow in association with long-term parenteral nutrition for short-bowel syndrome has not, to our knowledge, been reported previously and should now be considered in the differential diagnosis of bone marrow sea-blue histiocytosis. 相似文献
75.
76.
Charlotte W Ockeloen Marjolein H Willemsen Sonja de Munnik Bregje WM van Bon Nicole de Leeuw Aad Verrips Sarina G Kant Elizabeth A Jones Han G Brunner Rosa LE van Loon Eric EJ Smeets Mieke M van Haelst Gijs van Haaften Ann Nordgren Helena Malmgren Giedre Grigelioniene Sascha Vermeer Pedro Louro Lina Ramos Thomas JJ Maal Celeste C van Heumen Helger G Yntema Carine EL Carels Tjitske Kleefstra 《European journal of human genetics : EJHG》2015,23(9):1270-1185
Loss-of-function variants in ANKRD11 were identified as the cause of KBG syndrome, an autosomal dominant syndrome with specific dental, neurobehavioural, craniofacial and skeletal anomalies. We present the largest cohort of KBG syndrome cases confirmed by ANKRD11 variants reported so far, consisting of 20 patients from 13 families. Sixteen patients were molecularly diagnosed by Sanger sequencing of ANKRD11, one familial case and three sporadic patients were diagnosed through whole-exome sequencing and one patient was identified through genomewide array analysis. All patients were evaluated by a clinical geneticist. Detailed orofacial phenotyping, including orthodontic evaluation, intra-oral photographs and orthopantomograms, was performed in 10 patients and revealed besides the hallmark feature of macrodontia of central upper incisors, several additional dental anomalies as oligodontia, talon cusps and macrodontia of other teeth. Three-dimensional (3D) stereophotogrammetry was performed in 14 patients and 3D analysis of patients compared with controls showed consistent facial dysmorphisms comprising a bulbous nasal tip, upturned nose with a broad base and a round or triangular face. Many patients exhibited neurobehavioural problems, such as autism spectrum disorder or hyperactivity. One-third of patients presented with (conductive) hearing loss. Congenital heart defects, velopharyngeal insufficiency and hip anomalies were less frequent. On the basis of our observations, we recommend cardiac assessment in children and regular hearing tests in all individuals with a molecular diagnosis of KBG syndrome. As ANKRD11 is a relatively common gene in which sequence variants have been identified in individuals with neurodevelopmental disorders, it seems an important contributor to the aetiology of both sporadic and familial cases. 相似文献
77.
OBJECTIVE: To assess the effectiveness of a non-pharmacological intervention in patients with asthma on conventional therapy including inhaled corticosteroid. DESIGN: A randomised controlled trial of the Buteyko technique in a group of adults with asthma. The control group was trained by a physiotherapist in breathing and relaxation techniques. SETTING: A single centre associated with a University-based asthma programme. MAIN OUTCOME MEASURE: Asthma control, defined by a composite score based on the Canadian asthma consensus report 6 months after completion of the intervention. RESULTS: Both groups showed substantial and similar improvement and a high proportion with asthma control 6 months after completion of the intervention. In the Buteyko group the proportion with asthma control increased from 40% to 79% and in the control group from 44% to 72%. In addition the Buteyko group had significantly reduced their inhaled corticosteroid therapy compared with the control group (p=0.02). None of the other differences between the groups at 6 months were significant. CONCLUSIONS: Six months after completion of the interventions, a large majority of subjects in each group displayed control of their asthma with the additional benefit of reduction in inhaled corticosteroid use in the Buteyko group. The Buteyko technique, an established and widely recognised intervention, or an intensive programme delivered by a chest physiotherapist appear to provide additional benefit for adult patients with asthma who are being treated with inhaled corticosteroid. 相似文献
78.
In vivo treatment with recombinant IL-12 protects C57BL/6J mice against secondary alveolar echinococcosis 总被引:1,自引:0,他引:1
ISABELLE EMERY CLAUDE LECLERC KAPPRASEUTH SENGPHOMMACHANH DOMINIQUE ANGÈLE VUITTON & MARTINE LIANCE 《Parasite immunology》1998,20(2):81-91
Using an experimental model of hepatic Echinococcus multilocularis infection in C57BL/6J mice, intraperitoneal administration of 0.8 μg of recombinant IL-12 to mice with an established infection was shown to reduce the parasite burden as soon as two weeks after the end of treatment. At that time, in vitro Echinococcus multilocularis -induced spleen T cell proliferative responses as well as IFN-γ and IL-5 production were higher in IL-12 treated mice than in untreated mice. Administration of 0.8 μg of IL-12 at the time of infection was shown to be without effect on the parasite establishment. However, this treatment greatly inhibited the subsequent metacestode development. Indeed, ten weeks after infection, it induced a complete healing in 37.5% of mice. At that time, the development of metastases was inhibited in 68.75% of IL-12-treated mice. This reduction of parasite burden was mainly associated with a strong proliferation of spleen cells to E. multilocularis antigen and with a high IFN-γ production. Altogether, our results show that IL-12 is of crucial importance in inhibiting the larval growth after the metacestode establishment in the liver and suggest that this cytokine could be of potential value in the treatment of human alveolar echinococcosis . 相似文献
79.
80.
Ilufredo Y. Tantoy Bruce A. Cooper Anand Dhruva Janine Cataldo Steven M. Paul Yvette P. Conley Marilyn Hammer Fay Wright Laura B. Dunn Jon D. Levine Christine Miaskowski 《Journal of pain and symptom management》2018,55(3):808-834