全文获取类型
收费全文 | 540篇 |
免费 | 40篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 71篇 |
妇产科学 | 7篇 |
基础医学 | 63篇 |
口腔科学 | 11篇 |
临床医学 | 77篇 |
内科学 | 125篇 |
皮肤病学 | 18篇 |
神经病学 | 26篇 |
特种医学 | 94篇 |
外科学 | 20篇 |
综合类 | 10篇 |
预防医学 | 17篇 |
眼科学 | 1篇 |
药学 | 24篇 |
中国医学 | 1篇 |
肿瘤学 | 15篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2018年 | 7篇 |
2017年 | 10篇 |
2016年 | 8篇 |
2015年 | 17篇 |
2014年 | 11篇 |
2013年 | 27篇 |
2012年 | 12篇 |
2011年 | 12篇 |
2010年 | 31篇 |
2009年 | 19篇 |
2008年 | 14篇 |
2007年 | 8篇 |
2006年 | 10篇 |
2005年 | 10篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 9篇 |
2001年 | 9篇 |
2000年 | 4篇 |
1999年 | 9篇 |
1998年 | 22篇 |
1997年 | 31篇 |
1996年 | 27篇 |
1995年 | 31篇 |
1994年 | 23篇 |
1993年 | 37篇 |
1992年 | 5篇 |
1991年 | 7篇 |
1990年 | 15篇 |
1989年 | 16篇 |
1988年 | 17篇 |
1987年 | 11篇 |
1986年 | 13篇 |
1985年 | 13篇 |
1984年 | 3篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 14篇 |
1980年 | 6篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1976年 | 12篇 |
1975年 | 4篇 |
1968年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有581条查询结果,搜索用时 15 毫秒
21.
22.
Arbour NC; Zlotogora J; Knowlton RG; Merin S; Rosenmann A; Kanis AB; Rokhlina T; Stone EM; Sheffield VC 《Human molecular genetics》1997,6(5):689-694
Achromatopsia is an autosomal recessive disease of the retina,
characterized clinically by an inability to distinguish colors, impaired
visual acuity, nystagmus and photophobia. A genome-wide search for linkage
was performed using an inbred Jewish kindred from Iran. To facilitate the
genome-wide search, we utilized a DNA pooling strategy which takes
advantage of the likelihood that the disease in this inbred kindred is
inherited by all affected individuals from a common founder. Equal molar
amounts of DNA from all affected individuals were pooled and used as the
PCR template for short tandem repeat polymorphic markers (STRPs). Pooled
DNA from unaffected members of the kindred was used as a control. A
reduction in the number of alleles in the affected versus control pool was
observed at several loci. Upon genotyping of individual family members,
significant linkage was established between the disease phenotype and
markers localized on chromosome 2. The highest LOD score observed was 5.4
(theta = 0). When four additional small unrelated families were genotyped,
the combined peak LOD score was 8.2. Analysis of recombinant chromosomes
revealed that the disease gene lies within a 30 cM interval which spans the
centromere. Additional fine-mapping studies identified a region of
homozygosity in all affected individuals, narrowing the region to 14 cM. A
candidate gene for achromatopsia was excluded from this disease interval by
radiation hybrid mapping. Linkage of achromatopsia to chromosome 2 is an
essential first step in the identification of the disease-causing gene.
相似文献
23.
EM Laursen A Juul S Lanng N H?iby C Koch J Müller NE Skakkebaek 《Archives of disease in childhood》1995,72(6):494-497
Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor-I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function, and linear growth. Available data on IGF-I in cystic fibrosis are sparse and conflicting. From 1990-3, 235 of our 240 patients (114 males, 121 females, median age 16.2 years, ranged 0.1-44.0 years) had IGF-I measured once by radioimmunoassay. IGF-I was significantly reduced compared with a healthy Scandinavian control population: mean (-2 SD to +2 SD) IGF-I SD score was -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females. Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females. In patients who were still in the growth period a significant correlation of IGF-I SD score to height SD score (r = 0.28, p < 0.001) was found. The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern. 相似文献
24.
Immunological and functional protein S, protein C and antithrombin III levels and anticoagulant responses to activated protein C were measured in 24 patients with stroke in childhood. No hereditary deficiencies were found. The protein S levels in healthy controls of younger age did not differ from the adult levels. For optimal screening of protein S deficiency, measurements using functional as well as immunological assays are recommended. Appropriate criteria for the diagnosis of the deficiencies must be carefully applied if unnecessary anxiety and inappropriate treatment of children are to be avoided. 相似文献
25.
Evaluation of attempted prevention of unexpected infant death in very high-risk infants by planned health care 总被引:1,自引:0,他引:1
Three hundred and ninety-six babies born in Sheffield between 1982 and 1990 identified as being at "very high risk" of unexpected infant death by means of a scoring system, received an intensive programme of health care including a case discussion between a paediatrician, the GP and the health visitor held in the family doctor's surgery, weekly visits from the health visitor and informal hospital admission. Significantly fewer sudden unexpected infant deaths occurred in this group than were expected by logistic regression anlysis or occurred in the best available control group with comparable scores ( p = 0.024). Problems in evaluation include identification of an adequate control population, ethical difficulties in introducing a controlled study when the programme is already perceived as effective, and the calculation of "expected death rates". The results of this study indicate that very energetic programmes of intervention may prevent some deaths in vulnerable infants. 相似文献
26.
Radiographs, computed tomograms, and radionuclide bone scans were obtained preoperatively in three children with fibromatosis involving the bones and soft tissues of the extremities. Two of the children had identical scar-like bone lesions of the proximal tibia, which, to the authors' knowledge, have not been reported before in this disease. The lesions recurred in two children. 相似文献
27.
28.
29.
Computed tomography of abdominal fatty masses 总被引:2,自引:0,他引:2
30.