Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal carcinoma: non-mucinous tumour associated with an improved survival

AIMS: Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy has been reported as a treatment option for patients with peritoneal carcinomatosis from colorectal carcinoma. METHODS: Thirty patients with colorectal peritoneal carcinomatosis underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy. All appendiceal cancers were excluded. All patients were followed until January 2006 or death. Univariate analysis was performed to evaluate significant prognostic factors for overall survival, defined from the time of surgery. RESULTS: There were 13 male patients. The mean age at the time of surgery was 54years. There was no hospital mortality. The mean duration of hospital stay was 27days. The overall median survival was 29months, with 1- and 2-year survival of 72% and 64%, respectively. Twenty-one patients had complete cytoreduction and their 1- and 2-year survival rates were 85% and 71%, respectively. Univariate analysis demonstrated that patients with non-mucinous colorectal adenocarcinoma, Peritoneal Cancer Index (PCI) < or =13, and complete cytoreduction were associated with an improved survival. CONCLUSIONS: This study reported on 30 patients who underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. Patients with mucinous tumour had relatively more extensive intraperitoneal disease. Non-mucinous colorectal adenocarcinoma, PCI < or =13, and complete cytoreduction were associated with an improved survival.     

二紫胶囊治疗无排卵性不孕症60例

目的：评价二紫胶囊治疗无排卵性不孕症的临床疗效并探讨其作用机制。方法：将120例无排卵性不孕症患者随机分为治疗组（二紫胶囊）、对照组（克罗米芬胶囊）各60例。按规定的方法及标准服药，以3个月经周期为1个疗程。观察两组治疗前后基础体温、血清雌孕激素水平、临床症状、卵泡发育及有无妊娠等指标。结果：治疗组在妊娠情况方面与对照组对比，有高度显著性差异（P〈0．01）；在中医症侯改善、卵泡直径变化、不良反应方面对比，有显著性差异（P〈0．05）；在排卵情况、血清E2、P变化、BBT曲线变化、安全性指标等方面对比，无显著性差异（P〉0．05）。结论：二紫胶囊治疗无排卵性不孕症有良好的临床疗效及安全性，尤在促进卵泡的发育及成熟、提高妊娠率及改善临床症状方面显示出明显优势。     

非霍奇金淋巴瘤1125例临床病理分析

目的 探讨修订的欧美/世界卫生组织非霍奇金淋巴瘤新分类方案的临床意义.方法 按REAL/WHO淋巴瘤分类方案,对1996年1月至2003年6月间有计划地应用含蒽环类药物为基础的联合化疗方案加或不加放射治疗所治疗的1125例NHL的临床病理特点、疗后完全缓解(CR)率、长期生存率、预后因素及其临床相关性进行了分析;同时对NHL主要病理类型的临床特点和长期生存率进行了总结.结果 本组NHL主要病理类型包括弥漫性大B细胞淋巴瘤368例(32.7%);非特异性外周T细胞淋巴瘤137例(12.2%);鼻腔NK/T细胞淋巴瘤110例(9.8%);滤泡淋巴瘤98例(8.7%);结外黏膜相关淋巴瘤69例(6.1%);原发纵隔大B细胞淋巴瘤59例(5.2%);B细胞小淋巴细胞淋巴瘤52例(4.6%);T淋巴母细胞淋巴瘤51例(4.5%);间变大细胞淋巴瘤32例(2.8%).全组疗后完全缓解(CR)率为62.0%,5年无病生存率和总生存率分别为46.8%与52.3%.临床分析显示,临床分期晚(Ⅲ、Ⅳ期),行为状态评分为ECOG 2～4,有全身症状,高龄(＞60岁),巨块病变(≥10.0cm),血清乳酸脱氢酶增高,结外器官受侵＞1个部位以及骨髓、胃肠道、肝、肺、中枢神经系统受侵为不良预后因素(P＜0.001).不同NHL亚型具有独特的临床特征和长期生存率.结论 结果提示NHL新病理分类方案对NHL的分类、指导治疗和了解预后有意义,尤其是为NHL的个体化治疗提供了依据.     

多元线性回归——最优子集法编程及科研实例

目的:在科研工作中推广应用统计回归方法。方法:以VBA语言自编多元回归最优子集法软件模块,加载于Excel平台,并予以剖析及实例应用。结果:程序按“预回归最优子集回归”步骤顺序回归,最终提供“最优”、“次优”及“较优”等3个处理结果。结论:该软件模块运用方便,可正确使用公认准则进行数据处理。     

妇产科盆腔手术中输尿管损伤96例分析

目的 :探讨妇产科盆腔手术中减少及避免输尿管损伤的措施。方法 :回顾分析妇产科盆腔手术所致输尿管损伤 96例的临床资料。结果 :术中及时发现和术后 4 8h内明确诊断 5 6例 ,均Ⅰ期修复成功 ;术后延迟诊断明确 4 0例 ,除 2例行肾切除术、1例死亡外 ,37例经暂时性尿流改道后 ,Ⅱ期修复成功。结论 :手术野渗液多 ,输尿管扩张 ,术后腰腹疼痛 ,不明原因发热伴切口渗液 ,无尿或腹腔积液等应考虑输尿管损伤的可能。术前充分准备 ,进行相关检查 ,术中分清解剖关系 ,细心操作 ,术后密切观察是防治输尿管损伤的关键     

Viral load of high-risk human papillomavirus in cervical squamous intraepithelial lesions.

OBJECTIVES: This case-control study was conducted to investigate the role of viral load of high-risk human papillomaviruses (HPVs) in the development of cervical squamous intraepithelial lesions (SILs) and invasive cancers. METHODS: A total of 30 female cases who had histological evidence of low-grade SIL (n=10) or high-grade SIL and above (n=20) were identified as the case group at the Tri-Service General Hospital, Taipei between September 1998 and March 1999. In addition, 80 female controls who had normal cervical cytology were enrolled and individually matched on age (+/-5 years) and date of recruitment to each case. Cervical swabs collected from study subjects were tested for the positivity and viral load of high-risk HPVs by Hybrid Capture II assay. Additionally, subjects completed a risk factor questionnaire. RESULTS: Among sex behavioral factors studied, younger age at first intercourse was associated with a significantly elevated risk of cervical SIL and invasive cancers. With respect to HPV infection, high-risk HPV DNA was present in 70% (21/30) of case and 21% (17/80) of control subjects, resulting in an odds ratio (OR) of 6.6 [95% confidence interval (C.I.)=2.6-17.0]. Moreover, women who had a high viral load were at significantly greater risk for cervical SIL and invasive cancers than those who were infected with a low viral load (OR=18.0, 95% C.I.=3.0-108.5). CONCLUSIONS: Among the variables tested, infection with a high viral load of high-risk HPVs is the strongest determinant for cervical SIL and cervical cancers in Taiwan.     

Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake.

Dietary isoflavones are biologically active in humans, but few observational data exist on the relationship between isoflavone intake and excretion in Western populations. We examined associations between self-reported soy intakes and overnight urinary isoflavone excretion in a population-based sample of western Washington State women, and we investigated the usefulness of one versus two overnight urine samples, collected 48 h apart, as a biomarker of intake. Isoflavones (genistein, daidzein, O-desmethylangolensin, and equol) were measured in two overnight urine collections from 363 women recruited from a health maintenance organization. Soy food intakes were assessed using two 1-day diet records completed on each day prior to the urine collections and a food frequency questionnaire (FFQ) that had been completed by 312 of the women with regard to their dietary habits 3.5 years (range, 2-5 years) before the urine collections. Twenty-one percent of the women consumed soy on either day of the diet recall, and 13% and 34% of the women consumed soy at least once a week or at least once a month, respectively, according to the FFQ. Women who consumed soy at either of the two diet recalls or at the FFQ (at least once a week or at least once a month) had a significantly higher urinary excretion of isoflavones than women who did not consume soy (P < 0.01). Among women who consumed soy at either of the two diet recalls or at the FFQ (soy consumed at least once a month), isoflavone intake and excretion correlated significantly (P < 0.01). Excretion of the individual isoflavones correlated significantly between the two urine samples collected 48 h apart (genistein, r = 0.41 and P < 0.001; daidzein, r = 0.30 and P < 0.001; O-desmethylangolensin, r = 0.46 and P < 0.001; equol, r = 0.60 and P < 0.001). Differences between soy consumers and nonconsumers and associations between intakes and excretion remained significant whether one or both urine collections were considered. Measuring isoflavone excretion in one overnight urine collection serves as a biomarker of recent or past isoflavone intake, even in populations whose intake of soy foods is relatively low.     

复方丹参滴丸联合心得安对肝纤维化及门脉高压的影响

1999年6～9月，我们采用复方丹参滴丸联合心得安治疗肝炎肝硬化30例，以观察其降低门脉高压及肝纤维化程度的变化，现报告如下。     

Successful resuscitation of acute massive pulmonary embolism with extracorporeal membrane oxygenation and open embolectomy

Acute massive pulmonary embolism is usually fatal if not treated aggressively, but the management is not standardized. Open pulmonary embolectomy retains a role in the treatment of this disastrous disease. Extracorporeal membrane oxygenation has been used for cardiopulmonary support in some patients with life-threatening pulmonary embolism. This article details our experience of a 58-year-old woman suffering from acute cardiopulmonary collapse caused by massive pulmonary embolism. Under extracorporeal membrane oxygenation support, the patient received pulmonary angiography and underwent open embolectomy for a definitive treatment.