全文获取类型
收费全文 | 10148篇 |
免费 | 776篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 230篇 |
妇产科学 | 128篇 |
基础医学 | 1486篇 |
口腔科学 | 75篇 |
临床医学 | 1113篇 |
内科学 | 2744篇 |
皮肤病学 | 149篇 |
神经病学 | 829篇 |
特种医学 | 430篇 |
外科学 | 1504篇 |
综合类 | 23篇 |
一般理论 | 1篇 |
预防医学 | 562篇 |
眼科学 | 187篇 |
药学 | 729篇 |
中国医学 | 20篇 |
肿瘤学 | 696篇 |
出版年
2023年 | 59篇 |
2022年 | 107篇 |
2021年 | 294篇 |
2020年 | 149篇 |
2019年 | 281篇 |
2018年 | 313篇 |
2017年 | 219篇 |
2016年 | 240篇 |
2015年 | 299篇 |
2014年 | 415篇 |
2013年 | 514篇 |
2012年 | 911篇 |
2011年 | 920篇 |
2010年 | 482篇 |
2009年 | 416篇 |
2008年 | 706篇 |
2007年 | 686篇 |
2006年 | 719篇 |
2005年 | 659篇 |
2004年 | 625篇 |
2003年 | 578篇 |
2002年 | 505篇 |
2001年 | 87篇 |
2000年 | 67篇 |
1999年 | 86篇 |
1998年 | 104篇 |
1997年 | 64篇 |
1996年 | 45篇 |
1995年 | 40篇 |
1994年 | 42篇 |
1993年 | 36篇 |
1992年 | 36篇 |
1991年 | 24篇 |
1990年 | 29篇 |
1989年 | 19篇 |
1988年 | 21篇 |
1987年 | 16篇 |
1986年 | 14篇 |
1985年 | 20篇 |
1984年 | 9篇 |
1983年 | 14篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1977年 | 6篇 |
1975年 | 6篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1972年 | 6篇 |
1971年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Prostate cancer is the most common noncutaneous cancer and the second leading cause of death from cancer in men in most western countries. Advanced prostate cancer is typically sensitive to androgen‐deprivation therapy, but invariably progresses to the castration‐resistant state. Most current prostate cancer treatments are based on cytotoxicity directed against tumor cells via androgen‐deprivation therapy or chemotherapy. Chemotherapy with docetaxel represents the standard first‐line treatment in patients with castration‐resistant prostate cancer (CRPC). Following progression after treatment with docetaxel, cabazitaxel (XRP6258)–prednisone treatment leads to a significantly longer overall survival (OS) time than with mitoxantrone–prednisone. Several other novel agents are currently being evaluated, including sipuleucel‐T, abiraterone acetate, and MDV3100, as well as the radionuclide alpharadin. The cell‐based immunotherapy sipuleucel‐T produces longer OS times in chemotherapy‐naïve patients, whereas the androgen biosynthesis inhibitor abiraterone acetate results in longer OS times following docetaxel. It is envisioned that these agents will change the standard of care for patients with metastatic CRPC. This review focuses on the clinical development of cabazitaxel and abiraterone acetate. 相似文献
92.
Les points chauds de l’actualité en 2017. Une sélection du comité de rédaction du Bulletin du Cancer
93.
94.
Ronan Grimandi Florine Tissier Christophe Andro Dominique Tardy Franois-Xavier Gunepin Fabrice Rannou Marie-Agns Giroux-Metges 《Medicine》2022,101(37)
Ankle sprains (AS) are common in the military population, with a prevalence 5 to 8 times higher than that for civilians. The aim of this study was to evaluate in patients with severe AS the impact of disuse on thigh muscle induced by unloading and immobilization due to care. This study focused on muscle trophicity and dynamometric strength. In this observational prospective study, assessments were repeated at 3 visits: close to injury, 15 and 30 days following the sprain. The injured limb was compared to the contralateral limb. A dynamometer assessment was used to monitor changes in strength and fatigue of the thigh muscles of both limbs. Isometric and isokinetic concentric evaluation of peak torque (PTiso and PTdyn), total work (Wt), and peak torque time integral (IPT) of thigh muscles. Full follow-up was obtained in 30 subjects. The injured limbs showed significant deficits in the mean (SD). The quadriceps PTiso and IPT deficits were −12.6% ± 1.9% (P < .0001) and −13.27% ± 1.8% (P < .0001), respectively. The quadriceps PTdyn showed a significant deficit since V2 (−12.2.5% ± 2.0). The quadriceps Wt presented a significant deficit of −4.2% ± 2.4 (P < .0007) at 1 month. The hamstring PTdyn deficit presented a mean loss of −16.5% ± 2.4% (P < .0001). The hamstring Wt deficit was −13.7% ± 2.3% (P < .001). The analysis of variance showed that the grade of the sprain had a significant effect on the quadriceps PTq deficit (P < .016) but not the type of discharge. Our study showed that disuse leads to a significant deficit in the strength of knee muscles within 1 month. It is noteworthy that the hamstrings are more affected than the quadriceps. The rehabilitation protocol to prevent the risk of iterative ankle injuries and secondary knee injuries should incorporate early training of both quadriceps and hamstrings. 相似文献
95.
Loetitia Favre Justine Cohen Julien Calderaro Adrien Pcriaux CongTrung Nguyen Rmi Bourgoin Laura Larnaudie Aurlie Dupuy Marie Ollier Emmanule Lechapt Ivan Sloma Christophe Tournigand Benoit Rousseau Anaïs Pujals 《Molecular oncology》2022,16(17):3055
Exonucleasic domain POLE (edPOLE) mutations, which are responsible for a hypermutated tumor phenotype, occur in 1–2% of colorectal cancer (CRC) cases. These alterations represent an emerging biomarker for response to immune checkpoint blockade. This study aimed to assess the molecular characteristics of edPOLE‐mutated tumors to facilitate patient screening. Based on opensource data analysis, we compared the prevalence of edPOLE mutations in a control group of unselected CRC patients (n = 222) vs a group enriched for unusual BRAF/RAS mutations (n = 198). Tumor mutational burden (TMB) and immune infiltrate of tumors harboring edPOLE mutations were then analyzed. In total, 420 CRC patients were analyzed: 11 edPOLE‐mutated tumors were identified, most frequently in microsatellite (MMR)‐proficient young (< 70 years) male patients, with left‐sided tumors harboring noncodon 12 KRAS mutation. The prevalence of edPOLE‐mutated tumors in the control vs the experimental screening group was, respectively, 0.45% (n = 1) vs 5.0% (n = 10). Among the 11 edPOLE‐mutated cases, two had a low TMB, three were hypermutated, and six were ultramutated. EdPOLE‐mutated cases had a high CD8+ tumor‐infiltrating lymphocyte (TIL) infiltration. These clinicopathological and molecular criteria may help to identify edPOLE mutations associated with a high TMB in CRC, and improve the selection of patients who could benefit from immunotherapy. 相似文献
96.
HoaLe Mai Sophie Deshayes ThiVanHa Nguyen Virginie Dehame AnneLaure Chn Sophie Brouard Christophe Blanquart 《Molecular oncology》2022,16(20):3606
Malignant pleural mesothelioma (MPM) is an aggressive cancer mainly related to asbestos exposure. Despite recent therapeutic advances, notably immunotherapies, the benefit remains limited and restricted to a small percentage of patients. Thus, a better understanding of the disease is needed to identify new therapeutic strategies. Recently, interleukin 7 receptor (IL‐7R) has been described as being expressed by MPM cells and associated with poorer patient survival. Thus, the aim of this work was to study the IL‐7R/IL‐7 pathway in MPM using patient samples. We found that, although more than 40% of MPM cells expressed IL‐7R, IL‐7 had no effect on their intracellular signaling. Accordingly, the addition of IL‐7 to the culture medium did not affect MPM cell growth. Using The Cancer Genome Atlas (TCGA) database, we showed that high IL7 gene expression in MPM tumors was associated with a higher overall patient survival and an induction of genes involved in the immune response. In pleural effusions (PEs), we found that IL‐7 concentration was not a good diagnostic biomarker. However, we observed that high IL‐7 levels in PEs were associated with shorter survival of MPM patients, but not of lung cancer patients. The prognostic value of IL‐7 was also conserved when only patients with epithelioid mesothelioma, the most common histological type of MPM, were analyzed. Taken together, our study suggests that, although the IL‐7R/IL‐7 signaling pathway is not functional in MPM cells, IL‐7 expression in PEs may have prognostic value in MPM patients. 相似文献
97.
98.
99.
Antipsychotics increase vesicular glutamate transporter 2 (VGLUT2) expression in thalamolimbic pathways 总被引:1,自引:0,他引:1
Moutsimilli L Farley S El Khoury MA Chamot C Sibarita JB Racine V El Mestikawy S Mathieu F Dumas S Giros B Tzavara ET 《Neuropharmacology》2008,54(3):497-508
Recently the two vesicular-glutamate-transporters VGLUT1 and VGLUT2 have been cloned and characterized. VGLUT1 and VGLUT2 together label all glutamatergic neurons, but because of their distinct expression patterns in the brain they facilitate our ability to define between a VGLUT1-positive cortical and a VGLUT2-positive subcortical glutamatergic systems. We have previously demonstrated an increased cortical VGLUT1 expression as marker of antidepressant activity. Here, we assessed the effects of different psychotropic drugs on brain VGLUT2 mRNA and protein expression. The typical antipsychotic haloperidol, and the atypicals clozapine and risperidone increased VGLUT2 mRNA selectively in the central medial/medial parafascicular, paraventricular and intermediodorsal thalamic nuclei; VGLUT2 protein was accordingly amplified in paraventricular and ventral striatum and in prefrontal cortex. The antidepressants fluoxetine and desipramine and the sedative anxiolytic diazepam had no effect. These results highlight the implication of thalamo-limbic glutamatergic pathways in the action of antipsychotics. Increased VGLUT2 expression in these neurons might constitute a marker for antipsychotic activity and subcortical glutamate neurotransmission might be a possible novel target for future generation antipsychotics. 相似文献
100.
Christophe Sifer Deborah Handelsman Emilie Grange Raphael Porcher Christophe Poncelet Brigitte Martin-Pont Brigitte Benzacken Jean-Philippe Wolf 《Journal of assisted reproduction and genetics》2009,26(11-12):575-581