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101.
Thomas F Campbell Christine Dollaghan Janine E Janosky P David Adelson 《J. Speech Lang. Hear. Res.》2007,50(4):1110-1119
PURPOSE: Interpreting the rapidly changing speech skills of young children recovering from neurological injury is difficult because developmental expectations are generally available only at relatively lengthy intervals (e.g., 6 or 12 months). In this research note, the authors describe the process of generating a Percentage of Consonants Correct-Revised (PCC-R; L. D. Shriberg, D. Austin, B. A. Lewis, J. L. McSweeny, & D. L. Wilson, 1997a) performance curve and illustrate some of its applications for assessing change in performance over time. METHOD: The authors compiled mean PCC-R scores from 16 samples of typically developing children (18-172 months) and used curve fitting to test more than 11,000 statistical models of monthly growth in PCC-R. They selected a parsimonious and developmentally plausible model with R(2) = .9839 (p < .0005) and used it to generate the PCC-R, standard deviation, and standard error expected at each monthly age. RESULTS: The PCC-R performance curve distinguished among 65 children (37-57 months of age) diagnosed independently with normal or disordered speech with a high degree of success. More important, the PCC-R performance curve can be used to identify the points at which children (18-172 months) recovering from neurological injury achieve normal-range consonant production. CONCLUSION: The curve-fitting approach holds promise as a means of interpreting temporal variations in speech production at a finer grain than existing normative data currently allow. 相似文献
102.
Psychosocial factors at work and perceived health among agricultural meat industry workers in France
Christine Cohidon Patrick Morisseau Francis Derriennic Marcel Goldberg Ellen Imbernon 《International archives of occupational and environmental health》2009,82(7):807-818
Objective The objective of this study was to describe the perceived health status of the meat industry employees—i.e., working in the
slaughtering, cutting, and boning of large animals and poultry—and its relation to their organisational and psychosocial constraints
at work.
Methods This postal survey included all 3,000 employees of the meat industry (beef, pork and poultry) in four districts in Brittany,
France, whose companies were affiliated with the agricultural branch of the national health insurance fund. The questionnaire
asked for social and demographic data and information describing their job and the organisation of their work. The psychosocial
factors at work were described according to Karasek’s questionnaire (demand, latitude and social support at work). Perceived
health was measured with the Nottingham Health Profile perceived health indicator.
Results This study shows the high prevalence of poor health reported by the workers in this industry. This poor perceived health was
worse in women and increased regularly with age. Among the psychosocial factors studied, high quantitative and qualitative
demand at work, inadequate resources for good work and to a lesser extent, inadequate prospects for promotion appear especially
associated with poor perceived health. Other factors often associated with poor perceived health included young age at the
first job and work hours that disrupt sleep rhythms (especially for women).
Conclusion Our results show that this population of workers is especially vulnerable from the point of view of perceived physical and
psychological health and is exposed to strong physical, organisational and psychosocial constraints at work. They also demonstrate
that poor perceived health is associated with some psychosocial (such as high psychological demand and insufficient resources)
and organisational factors at work. These results, in conjunction with those from other disciplines involved in studying this
industry, may help the companies to develop preventive activities. 相似文献
103.
Christine P Ellis 《American journal of orthodontics and dentofacial orthopedics》2004,126(1):20A-21A; author reply 21A
104.
Lorraine N Clark Eneli Haamer Helen Mejia-Santana Juliette Harris Suzanne Lesage Alexandra Durr Sabine Janin Bs Katja Hedrich Elan D Louis Lucien J Cote Howard Andrews Stanley Fahn Cheryl Waters Blair Ford Steven Frucht William Scott Christine Klein Alexis Brice Hanno Roomere Ruth Ottman Karen Marder 《Movement disorders》2007,22(7):932-937
Parkin mutations account for the majority of familial and sporadic early onset Parkinson's disease (EOPD) cases with a known genetic association. More than 100 mutations have been described in the Parkin gene that includes homozygous, compound heterozygous, and single heterozygous mutations. We have designed a Parkin mutation genotyping array (gene chip) that includes published Parkin sequence variants and allows their simultaneous detection. The chip was validated by screening 85 PD cases and 47 controls previously tested for Parkin mutations. Similar genotyping microarrays have been developed for other genetically heterogeneous diseases including age-related macular degeneration. Here, we show the utility of a genotyping array for Parkinson's disease by analysis of 60 subjects from the Genetic Epidemiology of Parkinson Disease (GEPD) study that includes 15 early-onset PD case probands and 45 relatives. 相似文献
105.
Neoplasms located in the lateral skull base region present a challenge for evaluation and management due to their difficult anatomic location and the complex reconstruction that is required following extensive tumor resection. Repair following tumor ablation requires a watertight dural seal, obliteration of the dead space, and coverage with vascularized soft tissue. Advances in radiologic imaging, diagnostic pathology, and surgical techniques and a multidisciplinary team for tumor ablation and reconstruction have significantly improved the treatment of these patients, minimized the occurrence of postoperative complications, and maximized patient outcome and quality of life. In this article, we present our experience in the reconstruction of extensive lateral skull base defects after tumor ablation. 相似文献
106.
107.
108.
Susan Miesfeldt Christine Hayden Netta Apedoe Sharon Jerome Andrea Fletcher 《Journal of community health》2010,35(2):109-114
Over 800 Maine residents will be diagnosed with colorectal cancer (CRC) this year, and nearly 300 will die from the disease.
While CRC screening can reduce these rates, it is only among insured populations that screening rates exceed 50%. This project
aimed to reduce barriers to, and increase rates of CRC screening among underinsured and uninsured women, ages 50 years and
over, residing in Cumberland County, Maine. The existing network of the Maine Breast and Cervical Health Program (MBCHP) was
used to reach the target population. A packet containing (1) an offer for no-cost fecal occult blood test (FOBT) screening
and CRC-related educational materials, and (2) a stamped, addressed postcard specifying the woman’s interest in these resources,
was mailed to 300 MBCHP enrollees residing in Cumberland County. Women requesting screening were contacted by phone to further
determine eligibility. Ninety-three women (31%) requested FOBT kits and 29 of these women requested educational materials.
Ten women were ineligible for screening because of previous colonoscopy. Fifty-two completed FOBT kits (63%) were returned;
all were negative. An additional 42 (14%) women requested educational materials only. To reduce the burden of CRC in Maine
and nationally, disparate populations must be reached with efficient and effective screening services. Established networks
are proven means for reaching uninsured and underinsured individuals with education, screening services, and necessary follow-up
care. This project serves as a model for the future development of similar programs statewide and nationally. 相似文献
109.
B n dicte Brichard Jacques Ninane Serge Gosseye Christine Verellen-Dumoulin Christiane Vermylen Jean Rodhain Guy Comu 《Pediatric hematology and oncology》1991,8(3):215-219
A 9-year-old boy presented with a small subcutaneous tumor of the trunk and diffuse bone marrow involvement. The first histological diagnosis given was undifferentiated malignancy possibly of neural crest origin and chemotherapy was started immediately using vincristine, cyclophosphamide, cisplatin, and teniposide (OPEC). Complete response was achieved after four courses of chemotherapy. Histological slides were then reviewed and the final diagnosis of alveolar rhabdomyosarcoma (RMS) was retained. Moreover, chromosome analysis of malignant cells in the bone marrow revealed a translocation involving chromosomes 2 and 13:t(2;13) (q35;q14). This specific karyotype finding has been recently reported in a few cases and could be specific for alveolar RMS. The patient had a relapse 7 months after diagnosis and died 4 months later. 相似文献
110.
Christine Boutin John Dyck Lee Benson Christine Houde Robert M. Freedom 《Pediatric cardiology》1992,13(3):176-177
Summary Balloon atrial septostomy is an established method of palliation for several forms of congenital heart disease. Previously performed under fluoroscopic x-ray control, recent reports have demonstrated the utility of transthoracic echocardiographic monitoring. We report the first application of uniplane transesophageal echocardiography (TEE) (6.7-mm probe) as an alternative imaging modality for control of ballon atrial septostomy on neonates in the intensive care unit. 相似文献