全文获取类型
收费全文 | 1912篇 |
免费 | 149篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 83篇 |
妇产科学 | 63篇 |
基础医学 | 267篇 |
口腔科学 | 21篇 |
临床医学 | 220篇 |
内科学 | 443篇 |
皮肤病学 | 39篇 |
神经病学 | 131篇 |
特种医学 | 58篇 |
外科学 | 214篇 |
综合类 | 43篇 |
预防医学 | 178篇 |
眼科学 | 14篇 |
药学 | 155篇 |
中国医学 | 16篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 24篇 |
2022年 | 25篇 |
2021年 | 46篇 |
2020年 | 28篇 |
2019年 | 44篇 |
2018年 | 70篇 |
2017年 | 46篇 |
2016年 | 53篇 |
2015年 | 62篇 |
2014年 | 90篇 |
2013年 | 108篇 |
2012年 | 137篇 |
2011年 | 117篇 |
2010年 | 89篇 |
2009年 | 59篇 |
2008年 | 99篇 |
2007年 | 87篇 |
2006年 | 106篇 |
2005年 | 107篇 |
2004年 | 82篇 |
2003年 | 72篇 |
2002年 | 54篇 |
2001年 | 48篇 |
2000年 | 39篇 |
1999年 | 41篇 |
1998年 | 12篇 |
1997年 | 10篇 |
1996年 | 19篇 |
1995年 | 11篇 |
1994年 | 7篇 |
1993年 | 10篇 |
1992年 | 31篇 |
1991年 | 34篇 |
1990年 | 20篇 |
1989年 | 19篇 |
1988年 | 13篇 |
1987年 | 17篇 |
1986年 | 10篇 |
1985年 | 17篇 |
1984年 | 12篇 |
1983年 | 8篇 |
1979年 | 7篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1975年 | 6篇 |
1974年 | 10篇 |
1973年 | 9篇 |
1971年 | 7篇 |
1970年 | 7篇 |
1968年 | 6篇 |
排序方式: 共有2082条查询结果,搜索用时 15 毫秒
51.
Dan Weng Robyn Marty-Roix Sandhya Ganesan Megan K. Proulx Gregory I. Vladimer William J. Kaiser Edward S. Mocarski Kimberly Pouliot Francis Ka-Ming Chan Michelle A. Kelliher Phillip A. Harris John Bertin Peter J. Gough Dmitry M. Shayakhmetov Jon D. Goguen Katherine A. Fitzgerald Neal Silverman Egil Lien 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(20):7391-7396
52.
Shah SH Crosslin DR Haynes CS Nelson S Turer CB Stevens RD Muehlbauer MJ Wenner BR Bain JR Laferrère B Gorroochurn P Teixeira J Brantley PJ Stevens VJ Hollis JF Appel LJ Lien LF Batch B Newgard CB Svetkey LP 《Diabetologia》2012,55(2):321-330
Aims/hypothesis
Insulin resistance (IR) improves with weight loss, but this response is heterogeneous. We hypothesised that metabolomic profiling would identify biomarkers predicting changes in IR with weight loss.Methods
Targeted mass spectrometry-based profiling of 60 metabolites, plus biochemical assays of NEFA, ??-hydroxybutyrate, ketones, insulin and glucose were performed in baseline and 6?month plasma samples from 500 participants who had lost ??4?kg during Phase I of the Weight Loss Maintenance (WLM) trial. Homeostatic model assessment of insulin resistance (HOMA-IR) and change in HOMA-IR with weight loss (?HOMA-IR) were calculated. Principal components analysis (PCA) and mixed models adjusted for race, sex, baseline weight, and amount of weight loss were used; findings were validated in an independent cohort of patients (n?=?22).Results
Mean weight loss was 8.67?±?4.28?kg; mean ?HOMA-IR was ?0.80?±?1.73, range ?28.9 to 4.82). Baseline PCA-derived factor 3 (branched chain amino acids [BCAAs] and associated catabolites) correlated with baseline HOMA-IR (r?=?0.50, p?0.0001) and independently associated with ?HOMA-IR (p?0.0001). ?HOMA-IR increased in a linear fashion with increasing baseline factor 3 quartiles. Amount of weight loss was only modestly correlated with ?HOMA-IR (r?=?0.24). These findings were validated in the independent cohort, with a factor composed of BCAAs and related metabolites predicting ?HOMA-IR (p?=?0.007).Conclusions/interpretation
A cluster of metabolites comprising BCAAs and related analytes predicts improvement in HOMA-IR independent of the amount of weight lost. These results may help identify individuals most likely to benefit from moderate weight loss and elucidate novel mechanisms of IR in obesity. 相似文献53.
Lien YH 《The American journal of medicine》2012,125(7):625-627
54.
55.
David Ryder Katalin Kraszlan Debbie Lien Elizabeth Allen Tanya Chiplin Suzanne Dick 《Psychiatry, Psychology and Law》2013,20(1):65-75
The Western Australian Court Diversion Service (CDS) is a post‐conviction / pre‐sentence program that aims to divert substance‐using offenders from the prison system and into treatment programs. It has been in operation since 1988, though a formal evaluation has not been conducted. The present study evaluated the outcomes for offenders referred to the program in relation to program completion, sentencing and re‐offending. It utilised a quasi‐experimental within groups design using data from client files from January 1998 to June 1999. Offenders who had higher motivation, attended treatment regularly and had less than 20 prior convictions were more likely to complete the program. A custodial sentence was more likely if the offender was male, had committed a serious offence, had more than 30 prior convictions, had lower motivation and had not completed the CDS program. Predictors of re‐offending included lower motivation and a previous custodial sentence. The offender's level of motivation to change and number of prior convictions were significant predictors of all three outcomes: program completion, sentencing and re‐offending. The findings highlight the importance of considering offender characteristics when assessing eligibility for diversion programs, addressing offender motivation within diversion programs and considering issues of which offenders are most likely to benefit from which programs. 相似文献
56.
57.
58.
59.
Maryann Stenvik Ole Tjomsland Steinar Lien Sigurd Gunnes Idar Kirkeby-Garstad 《Scandinavian cardiovascular journal : SCJ》2013,47(4):234-237
Objective. The aim of the study was to evaluate the impact of an additional subcutaneous suture line on the incidence of postoperative (p.o.) infection at the vena saphena magna harvesting site (VSMHS) after coronary artery bypass grafting (CABG). Methods. Two hundred and forty three patients undergoing CABG were included. Patients in Group A (n?=?119) all operated by one physical assistant (PA) were prospectively randomised into Group A1 (n?=?59) receiving intracutaneous closure suture alone whereas 60 patients (Group A2) received an additional subcutaneous suture line. Group B (n?=?120), operated by surgical residents, served as control population. All patients were due to follow-up at six weeks p.o. Results. Subcutaneous suture did not impact the p.o. infection rate (A2 vs. A1; 4/60 vs. 2/59, n.s.). A significant lower p.o. infection rate was observed in Group A vs. Group B (6/119 (5%) vs. 15/120 (13%) p?<?0.05). Conclusion. Subcutaneous suture did not impact the p.o. infection rate at VSMHS. The infection rate observed in patients operated by an experienced PA was significantly lower than in patients operated by various surgical residents. 相似文献
60.
J. W. Coughlin Ph.D. C. M. Gullion Ph.D. P. J. Brantley Ph.D. V. J. Stevens Ph.D. A. Bauck B.S. C. M. Champagne Ph.D. A. T. Dalcin R.D. K. L. Funk M.S. R.D. J. F. Hollis Ph.D. G. J. Jerome Ph.D. L. F. Lien M.D. C. M. Loria Ph.D. V. H. Myers Ph.D. L. J. Appel M.D. 《Annals of behavioral medicine》2013,46(3):369-381