猕猴桃中药复方制剂对血清SOD及MDA含量的影响

猕猴桃中药复方制剂系采用猕猴桃汁为基质，配加绞股蓝、丹参等中药的有效成分制成。为了研究它的保健作用，在６３例５０岁以上、无急性疾病的中、老年人，３６例３０～４９岁健康的青年，３２例１４～１７岁健康的少年中进行试验，１０ｍｌ每日２次连续服用３０天后，中老年人血液ＳＯＤ显著增高，７０岁以上老人平均增高２．８倍，血清ＭＤＡ明显下降，７０岁以上平均下降８７．５％。     

钛种植体－羟基磷灰石早期修复犬下颌骨缺损与骨结合的实验研究

本研究对钛种植体－羟基磷灰石（Ｔｉ－ＨＡ）在早期修复下颌骨缺损中与骨结合的界面形态进行了扫描电镜和Ｘ线能谱观察分析。通过对９只健康狗下颌骨缺损区植入Ｔｉ－ＨＡ２、６及１２周后Ｔｉ－ＨＡ／宿主骨界面及Ｔｉ／ＨＡ界面的扫描电镜观察和Ｘ线能谱分析，结果表明Ｔｉ－ＨＡ植入骨缺损区，不引起正常的骨矿化过程改变，与宿主骨形成骨性结合；Ｔｉ／ＨＡ界面有新骨形成；扫描电镜观察和Ｘ线能谱分析在研究骨缺损修复过程中不同阶段的组织成份的变化是一个重要手段。     

Ketanserin降低清醒自发性高血压大鼠血压波动性的机理初探

应用计算机化清醒大鼠血流动力学测定技术，观察５－ＨＴ２受体阻滞剂Ｒｉｔａｎｓｅｒｉｎ（Ｒｉｔ）和α１受体阻滞剂哌唑嗪对清醒自发性高血压大鼠（ＳＨＲ）的血压、血压波动性（ＢＰＶ）和动脉压力感受性反射血压控制部分（ＡＢＲ－ＢＰ）的效应，旨在初步探讨兼具５－ＨＴ２受体和α１受体阻滞作用地新型抗高血压药Ｋｅｔａｎｓｅｒｉｎ降低ＢＰＶ的机制。结果表明：Ｒｉｔ对ＳＨＲ无降压作用，但侧脑室给药明显提高ＡＢＲ－Ｂ     

血清唾液酸对血液病临床价值的初步报告

报道64例各类血液病患血清唾液酸（SA）值的测定，并与84例健康对照组进行比较。结果经统计学分析：病例组（631．5±130．3μg/ml），病例组中的ANLL（672．6±98．38μg/ml），ALL（630．8±29．3μg/ml），CML－A（617．5±122．7μg/ml），MM（606．0±138．7μg/ml四组与对照组比较，差异有极显意义（P＜0．01）；各病型组SA阳性率明显高于健康对照组，表明SA值的测定对恶性血液病的诊断有一定的临床意义。     

化学气相淀积过程中钛酸丁酯热解反应机理及动力学

利用热解-色质联用分析系统,对文题进行了研究,发现其热解过程是一个复杂的多元反应过程。在500～800℃,钛酸丁酯(Ⅰ)热解尾气产物主要是烯烃、醇、醚和醛类化合物。经热解机理分析,发现Ⅰ的重排断裂反应是整个热解过程的主反应,其反应动力学常数为3.87×10~5,活化能为69.3 kJ/     

Molybdenum requirement of female rats.

Sixty 3-wk-old female Sprague-Dawley rats were randomly divided into six groups of 10 animals each. Group 1 was fed for 8 wk purified AIN-76A diet (basal diet) containing 0.025 mg molybdenum/kg diet. Groups 2-6 were fed the same basal diet supplemented with sodium molybdate to provide total dietary Mo of 0.050, 0.100, 0.200, 0.400 and 0.800 mg/kg diet, respectively. Molybdenum concentration in liver and brain increased linearly up to the 0.200 mg Mo/kg diet level. Beyond this level, no further significant increase occurred. Dietary Mo of 0.100 mg/kg elevated the Mo concentration in heart to its maximal level. Supplementation with 0.025 mg Mo/kg to a total of 0.05 mg Mo/kg diet significantly increased Mo concentration in spleen and kidney; higher levels of dietary Mo did not result in further significant responses. Molybdenum supplementation significantly increased the activities of xanthine dehydrogenase/oxidase (XDH), sulfite oxidase and superoxide dismutase in the liver, and of XDH in small intestinal mucosa. Maximal activities were attained at 0.050, 0.050, 0.200 and 0.100 mg Mo/kg diet, respectively. Dietary Mo of 0.200 mg/kg diet was estimated as the Mo requirement of rats fed the AIN-76A diet.     

慢粒白血病abl癌基因表达的研究

选择分别位于ｂｃｒ／ａｂｌ嵌合基因的Ｍｂｃｒｌ第二外显子和ａｂｌ的第二外显子上的两条引物，对１８例慢粒白血病及２例急淋白血病标本进行逆转录ＰＣＲ（ＲＴ－ＰＣＲ）检测。结果：在１８例包括ｐｈ（＋）和ｐｈ（－）不同病期的慢粒白血病患者血中均检出ｂｃｒ／ａｂｌ嵌合基因的表达，其中１４例为Ｋ－２８型表达，１例为Ｌ－６型表达，３例为Ｋ－２８型，Ｌ－６型同时表达；２例急淋白血病标本中１例为Ｋ－２８型表达。研究结果表明，１．ｂｃｒ／ａｂｌ嵌合基因是慢粒白血病的一个重要分子生物学特征；２．ｐｈ（＋）和ｐｈ（－）慢粒白血病的分子生物学基础相同，即均有ｂｃｒ／ａｂｌ嵌合基因；３．至少部分急淋白血病与慢粒白血病有相同的分子生物学基础；４．ｂｃｒ的断裂点位置可能有一定的临床意义，但有待进一步研究；５．同时表达Ｌ－６型和Ｋ－２８型的情况多见于急变区，此现象提示体内可能同时有两类不同嵌合的白血病细胞或白血病急变期ｂｃｒ出现新的重排。     

原子吸收光谱法测定糖尿病患者血清锌、镁、钙含量的研究

采用原子吸收光谱法测定了30例糖尿病患者血清锌、镁、钙的含量,并与30例正常人相比较。结果表明,其锌和镁较正常人为低(P<0.05),但钙与正常人无显著性差别。另外,本文还对锌、镁与糖尿病的关系进行了探讨。     

Effect of estradiol on accelerated atherosclerosis in rabbit heterotopic aortic allografts.

Migration and proliferation of vascular smooth muscle cells are early and major events in the formation of atherosclerotic lesions. We report on an aorta transplant model in rabbits wherein myointimal proliferation is inhibited by 17-beta-estradiol. The abdominal aortas of outbred white New Zealand rabbits were harvested and allografted to the carotid artery of the recipient. The animals, which were fed either a normal or a high-cholesterol (0.5%) diet, were killed 3 weeks later. The degree of myointimal proliferation was measured with a digitized system attached to a light microscope. The myointimal hyperplasia was expressed as the cross section area of the intima/the area of the intima + the area of the media x 100. Transmission electron micrographs were obtained for all vessels. Intimal thickening was shown mainly to consist of proliferating smooth muscle cells. The cholesterol diet resulted in significantly higher serum total cholesterol levels compared to animals on a normal diet (p < 0.0001) but did not affect serum high-density lipoprotein-cholesterol or serum triglyceride levels. The cholesterol diet was also associated with a greater but not significant amount of intimal thickening. Treatment with 17-beta-estradiol significantly decreased both serum triglyceride concentration (p < 0.05) and myointimal thickening (p < 0.01) in cholesterol-fed animals. Transmission electron microscopy showed that the endothelial cells appeared structurally normal in the estradiol-treated animals. Further, estradiol prevented the appearance of vacuolized macrophages. Thus estradiol may decrease myointimal thickening by preserving the endothelium and preventing macrophage appearance in the intima.(ABSTRACT TRUNCATED AT 250 WORDS)     

Clinical analysis of 418 patients with Wilson's disease in traditional Chinese medicine and Western medicine therapy

From 1974 to 1988, 418 cases of Wilson's disease were treated with TCM-WM in our hospital. 147 cases were of Wilson's type; 149 cases were of pseudosclerosis type; 40 cases were of abdominal and hepatocerebral type; 21 cases were of choreoathetosis type and 21 cases of other types. After a course of treatment for 3 to 6 months, 103 patients showed marked improvement and 286 made some improvement, but no effect was found in 22 patients and 7 deaths were observed. The results were as follows: (1) The mortality in the severe and moderate groups were significantly higher than the mild (P less than 0.05) and the marked effective rate was less than the latter (P less than 0.01). (2) The marked effective rate was lower in abdominal and hepatocerebral type, and no significant difference was found in recovery rate between Wilson's type and pseudosclerosis type.