“I Started to Feel Better now”: Qualitative Findings from Client Narratives on Early Recovery in Inpatient Substance Use Treatment

International Journal of Mental Health and Addiction - While a plethora of studies indicating substance use treatment reduced measurable, pathological symptoms, research is still needed to explore...     

Characterizing the Time-Varying Brain Networks of Audiovisual Integration across Frequency Bands

Multisensory integration involves multiple cortical regions and occurs at multiple stages with attentional modulation. The structure of network formed by the interactive cortical regions reflects the state of working on a current task and changes continuously with the task processing. In addition, the neural oscillatory responses in various frequency bands are associated with different cognitive functions. Thus, studying topological characteristics of time-varying networks across multiple frequency bands helps to elucidate the mechanism of multisensory integration. Here, we designed an event-related experiment using auditory, visual, and audiovisual stimuli to record electroencephalographic data in both attended and unattended conditions and constructed delta-, theta-, alpha-, and beta-band networks at eight time points post-stimulus. We used graph theory to calculate global properties, nodal out-degree, and their correlation with behavioral performance. The increasing clustering coefficient and global efficiency and decreasing characteristic path length indicated that the brain had optimized the configuration across multiple frequency bands over time to efficiently process audiovisual integration. The differences in global properties and hub distributions showed that each frequency band–specificity system in the brain had a different topological structure, indicating that the networks on each frequency band contributed to various cognitive functions and involved in different stages of audiovisual integration. Our results suggest that differences in cognitive function are, at least partly, due to the different network structures across frequency bands and that the frequency band–specificity systems with different distribution are involved in various stages of audiovisual integration and attention modulation.

     

Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study

Brain Imaging and Behavior - As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction...     

纠正EDTA依赖性假性血小板减少的方法学比较和分析

目的 对比枸橼酸钠法、阿米卡星法、硫酸镁法和预稀释法对EDTA依赖性假性血小板减少症(Ethylene Diamine Tetraacetic Acid Dependent Pseudothrombocytopenia,EDTA-PTCP)血小板检测的应用效果.方法 重新采集EDTA-PTCP患者的EDTA-K2、枸橼...     

人源pEGFP-C1-p38γ真核表达质粒的构建及其功能研究

目的 构建人源pEGFP-C1-p38γ表达质粒,并观察其对乙醇刺激的L0-2肝细胞的增殖和凋亡及炎症因子分泌的影响.方法 在人源L0-2肝细胞中提取RNA并且逆转录为cDNA,同时将引物稀释到10μmol/L,其余作为储液备用.采用PCR技术扩增p38γ并鉴定,使用AxyPrep DNA凝胶回收试剂盒进行PCR产物的...     

Impact of wound microbiology on limb preservation in patients with diabetic foot infection

Aims/Introduction:To investigate the association between specific bacterial pathogens and treatment outcome in patients with limb‐threatening diabetic foot infection (LT‐DFI).Materials and Methods:Consecutive patients treated for LT‐DFI in a major diabetic foot center in Taiwan were analyzed between the years 2014 and 2017. Patients with positive wound culture results at first aid were enrolled. Clinical factors, laboratory data, and wound culture results were compared. Lower‐extremity amputations and in‐hospital mortality were defined as a poor outcome.Results:Among the 558 patients, 272 (48.7%) patients had lower extremity amputation and 22 (3.9%) patients had in‐hospital mortality. Gram‐negative bacterial (GNB) infection was the independent factor following factors adjustment. When all the 31 microorganisms were analyzed, only E. coli (adjusted odds ratio [aOR], 3.01; 95% CI, 1.60–5.65), Proteus spp. (aOR, 2.99; 95% CI, 1.69–5.29), and Pseudomonas aeruginosa (aOR, 2.00; 95% CI 1.20–3.32) were associated with poor outcome. The analysis of specific GNB species in association with major‐ or minor‐ amputation have been reported. No specific pathogen was associated with cause of death in patients with mortality within 30 days. The antimicrobial‐resistant strains were not associated with a poor treatment outcome.Conclusions:The presence of GNB was associated with limb amputations. This study provides insight into more timely and appropriate management of the diabetic foot infection.     

The Impact of Reproductive Factors on the Risk of Breast Cancer by ER/PR and HER2: A Multicenter Case-Control Study in Northern and Eastern China

BackgroundPrevious studies have suggested that reproductive factors are associated with breast cancer risk. Breast cancer subtypes have distinct natural characteristics and may also have unique risk profiles. The purpose of this study was to determine whether reproductive factors affect the risk of breast cancer by estrogen receptor (ER)/progesterone receptor (PR) and HER2 status.MethodsA multicenter, case-control study was conducted. There were 1170 breast cancer patients and 1170 age- and hospital-matched females included in the analysis. Self-reported data were collected about lifestyle behaviors, including reproductive factors. Breast cancer cases were categorized subtypes according to ER, PR, and HER2 expression as HR- positive, HER2-enriched, and triple negative breast cancer (TNBC). Multivariable logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).ResultsHaving ≤1 child increased risk of HR-positive breast cancer (OR 1.882; 95%CI 1.29-2.74), especially in the premenopausal group (OR 2.212; 95%CI 1.23-3.99). Compared with women who first gave birth after age 30 years, earlier age at first birth decreased the risk of HR-positive breast cancer (≤23 years: OR 0.209; 95%CI 0.14-0.30; 24-29 years: OR 0.256; 95%CI 0.18-0.36; P < .001). Compared with those who had an average breastfed/birth period of more than 2 years, those with an average period less than 6 months had an elevated risk of all subtypes (HR positive: OR 2.690; 95%CI 1.71-4.16, P < .001; HER2-enriched: OR 3.779; 95%CI, 1.62-8.79, P = .001; TNBC: OR 2.564; 95%CI 1.11-5.94, P = .022). For postmenopausal patients, shorter period of lifetime menstrual cycles (≤30 years) had an obviously decreased risk in HR-positive cases (OR 0.397; 95%CI 0.22-0.71), while there was no similar appearance in other molecular subtypes.ConclusionThe results suggest that reproductive behaviors affect risk of breast cancer differently according to ER/PR and HER2 status.     

Test–retest reliability of dynamic functional connectivity in naturalistic paradigm functional magnetic resonance imaging

Dynamic functional connectivity (dFC) has been increasingly used to characterize the brain transient temporal functional patterns and their alterations in diseased brains. Meanwhile, naturalistic neuroimaging paradigms have been an emerging approach for cognitive neuroscience with high ecological validity. However, the test–retest reliability of dFC in naturalistic paradigm neuroimaging is largely unknown. To address this issue, we examined the test–retest reliability of dFC in functional magnetic resonance imaging (fMRI) under natural viewing condition. The intraclass correlation coefficients (ICC) of four dFC statistics including standard deviation (Std), coefficient of variation (COV), amplitude of low frequency fluctuation (ALFF), and excursion (Excursion) were used to measure the test–retest reliability. The test–retest reliability of dFC in naturalistic viewing condition was then compared with that under resting state. Our experimental results showed that: (a) Global test–retest reliability of dFC was much lower than that of static functional connectivity (sFC) in both resting‐state and naturalistic viewing conditions; (b) Both global and local (including visual, limbic and default mode networks) test–retest reliability of dFC could be significantly improved in naturalistic viewing condition compared to that in resting state; (c) There existed strong negative correlation between sFC and dFC, weak negative correlation between dFC and dFC‐ICC (i.e., ICC of dFC), as well as weak positive correlation between dFC‐ICC and sFC‐ICC (i.e., ICC of sFC). The present study provides novel evidence for the promotion of naturalistic paradigm fMRI in functional brain network studies.     

Effect of ‘Q’ Ratio on Texture Evolution of Ti-3Al-2.5V Alloy Tube during Rolling

Ti-3Al-2.5V alloy was usually the α phase of HCP structure at room temperature which had obvious anisotropy. During tube rolling, α grain would be influenced by stress-strain state, deformation amount, ‘Q’ ratio to result the preferred orientation and formed texture. In order to obtain radial texture tube by rolling and improve the service quality of tube in the pipeline system, Φ25 mm Ti-3Al-2.5V alloy tubes was selected as billet for the experiment, and four kinds of tubes with outer diameter of Φ16mm was produced by single pass cold rolling with ‘Q’ ratios ranging from 0.65 to 2.0. The effect of ‘Q’ ratio on the texture of Ti-3Al-2.5V tube was studied. The result indicted that the initial texture of the tube is radial-circumferential equally distributed, and the radial basal texture enhances gradually with increasing ‘Q’ ratio. Since the angle between the C-axis of grain and the radial axis of RD decreases, the C-axis of grain distributes to the radial direction, and the more grain orientation from {112X} pyramidal to {0001} basal plane. The different ‘Q’ ratio would lead to different strain along the radial direction, circumferential direction, axial direction, thus affected the crystal orientation and distribution during tube rolling deformation. When ‘Q’ > 1, the tube mainly produced radial basal texture. By comparison with ‘Q’ < 1, the tube mainly produced circumferential basal texture. As a result, when the initial texture of the tube is radial-circumferential equally distributed, the ideal radial texture of the tube can be obtained by choosing rolling process with ‘Q’ > 2.0.