Four-year clinical performance of a lithia disilicate-based core ceramic for posterior fixed partial dentures

PURPOSE: The objective of this research was to test the hypothesis that 3-unit fixed partial dentures (FPDs) made from a moderately high-strength core ceramic will adequately resist fracture in posterior regions if fabricated with a minimal connector size of 4 mm. MATERIALS AND METHODS: Thirty ceramic FPD core frameworks were prepared using a hot-pressing technique and a lithia disilicate-based core ceramic. The maximum occlusal force was measured for each patient prior to tooth preparation. Connector heights and widths were measured for each FPD. Patients were recalled annually after cementation for 4 years and evaluated using 11 clinical criteria. All FPDs were examined by 2 independent clinicians, and rankings for each criterion were made from 1 to 4 (4 = excellent; 1 = unacceptable). RESULTS: The fracture rate was approximately 3% per year, and the proportion of good overall ratings in the nonfractured FPDs was reduced by more than 6% per year, where a good overall rating was defined to be a rank of 3 or 4 in all 11 criteria. There was little evidence that the use of either resin-reinforced glass-ionomer cement (Protec CEM) or dual-cure resin cement (Variolink II) made any difference in terms of fracture rate or overall rating (P= .30, .63, .97, and .71 for the 4 years, respectively). From a fracture resistance perspective, 4 of the 30 ceramic FPDs fractured within the 4-year evaluation period, representing an 86.7% success rate. Another FPD was replaced because of a caries lesion on 1 abutment tooth away from the margin. One FPD fracture was associated with the subject having the greatest occlusal force (1,031 N). The other 2 fractures were associated with FPDs that exhibited connector heights of less than 3 mm. All criteria were ranked good to excellent during the 4-year period for the remaining FPDs. CONCLUSION: Fractured FPDs were associated with a connector height of less than 4 mm; thus, the hypothesis was accepted.     

髁突骨折55例治疗体会

目的:探讨髁突骨折的治疗方法。方法:回顾性分析55例髁突骨折患者的资料,其中非手术治疗(保守治疗)40人,手术治疗15人,经随访1～5年,观察髁突骨折后成角和恢复情况与远期临床疗效的关系。结果:行保守和手术治疗者的平均髁突骨折移位角度分别为27°和56°,平均年龄分别为23岁和36岁。结论:根据髁突骨折移位角度和年龄来选择保守治疗或手术治疗,其远期效果较好。     

白细胞介素-1单核苷酸多态性与甘肃回族、东乡族人群慢性牙周炎的相关性研究

目的 通过检测并分析白细胞介素(IL)-1B+3954位点的单核苷酸多态性(SNP),探索其与甘肃回族与东乡族人群慢性牙周炎的关系.方法 收集215例回族、东乡族慢性牙周炎患者及219例正常对照组健康者的静脉血,提取外周静脉血白细胞DNA,采用聚合酶链式反应-限制性片段长度多态性技术(PCR-RFLP)方法检测IL-1...     

双侧卵巢肿瘤生育力保存的1例报道并文献复习

目的 探讨年轻卵巢肿瘤患者保留生育力的相关诊疗方案.方法 回顾性剖析该院1例双侧卵巢肿瘤患者的临床资料及诊疗过程,并复习国内外相关文献.结果 患者术后定期随访肿瘤标志物及影像学检查,均未见明显异常,现已获得满意的妊娠结局(2/3),其并未借助任何辅助生殖技术分别于2015、2018年于该院产科顺产两活婴.结论 年轻的卵巢肿瘤患者除了行保留生育力治疗,还可采取相应措施来保护患者的卵巢功能.     

双侧卵巢肿瘤生育力保存的1例报道并文献复习

目的 探讨年轻卵巢肿瘤患者保留生育力的相关诊疗方案.方法 回顾性剖析该院1例双侧卵巢肿瘤患者的临床资料及诊疗过程,并复习国内外相关文献.结果 患者术后定期随访肿瘤标志物及影像学检查,均未见明显异常,现已获得满意的妊娠结局(2/3),其并未借助任何辅助生殖技术分别于2015、2018年于该院产科顺产两活婴.结论 年轻的卵巢肿瘤患者除了行保留生育力治疗,还可采取相应措施来保护患者的卵巢功能.     

Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): radiographic observations

Aim: The objective of this study was to radiographically evaluate the potential of a purpose‐designed titanium porous‐oxide implant surface coated with recombinant human bone morphogenetic protein‐7 (rhBMP‐7), also known as recombinant human osteogenic protein‐1 (rhOP‐1), to stimulate alveolar ridge augmentation. Material and Methods: Six young‐adult Hound Labrador mongrel dogs were used. Three 10 mm titanium oral implants per jaw quadrant were placed 5 mm into the alveolar ridge in the posterior mandible following surgical extraction of the pre‐molar teeth and reduction of the alveolar ridge leaving 5 mm of the implants in a supra‐alveolar position. The implants had been coated with rhBMP‐7 at 1.5 or 3.0 mg/ml and were randomized to contralateral jaw quadrants using a split‐mouth design. The mucoperiosteal flaps were advanced, adapted, and sutured to submerge the implants. Radiographic registrations were made immediately post‐surgery (baseline), and at weeks 4 and 8 (end of study). Results: rhBMP‐7‐coated implants exhibited robust radiographic bone formation. At 8 weeks, bone formation averaged 4.4 and 4.2 mm for implants coated with rhBMP‐7 at 1.5 and 3.0 mg/ml, respectively. There were no significant differences between the rhBMP‐7 concentrations at any observation interval. A majority of the implant sites showed voids within the newly formed bone at week 4 that generally resolved by week 8. The newly formed bone assumed characteristics of the resident bone. Conclusions: The titanium porous‐oxide implant surface serves as an effective carrier for rhBMP‐7 showing a clinically significant potential to stimulate local bone formation.     

新生期小鼠七氟醚暴露对其青春期学习记忆及海马组织髓鞘损伤的影响

目的 探究新生期小鼠七氟醚暴露对其青春期学习记忆的影响及其相关机制.方法 6日龄C57BL/6小鼠随机分为对照组(CON组)、七氟醚组(SEVO组)、对照+氯化锂组(LiCl组)、七氟醚+氯化锂组(SEVO+ LiCl组).SEVO组为3％七氟醚连续暴露3d(第6～8天),每天1次,每次2 h,CON组为60％氧气对照,LiCl组为60％氧气暴露前30 min腹腔注射GSK3β抑制剂氯化锂(100 mg/kg),SEVO+LiCl组为七氟醚暴露前30 min腹腔注射氯化锂(100 mg/kg).新物体识别实验和Y迷宫实验检测小鼠第30～32天学习记忆功能;Western blot检测小鼠海马组织髓鞘碱性蛋白(MBP)、β-catenin蛋白表达及pGSK3β/GSK3β比值变化.结果 行为学实验结果显示,SEVO组小鼠识别指数和新臂探索次数百分比均低于CON组(P＜0.05).氯化锂预处理后,SEVO+ LiCl组小鼠识别指数和新臂探索次数百分比较SEVO组升高(P＜0.05),学习记忆功能改善.Western blot结果显示,SEVO组小鼠海马组织MBP蛋白、β-catenin蛋白表达及pGSK3β/GSK3β比值均低于CON组(P＜0.05),氯化锂预处理后,与SEVO组比较,SEVO+ LiCl组小鼠海马组织MBP蛋白、β-catenin蛋白表达增加,pGSK3β/GSK3β比值升高(P＜0.05).结论 新生期小鼠七氟醚暴露致青春期学习记忆功能受损,可能与抑制GSK3β/β-catenin信号通路中GSK3β(Ser9)磷酸化导致的海马组织髓鞘损伤有关.     

急性脑梗塞介入治疗的疗效观察

目的:观察急性脑梗塞介入治疗的近远期疗效.方法:2018年12月至2019年12月收治的78例急性脑梗塞患者,随机分为观察组与对照组,每组各39例;观察组患者进行介入治疗,对照组进行静脉溶栓治疗;比较两组患者的临床疗效、治疗前后各时间段的NIHSS评分和mRS评分.结果:观察组患者的治疗有效率为92.31％,对照组患者的治疗有效率为74.36％,观察组治疗有效率高于对照组,差异显著(P<0.05).治疗后1、2个月观察组NIHSS评分均低于对照组(P<0.05);治疗后3个月两组NIHSS评分无显著差异(P>0.05).治疗后6、12个月观察组mRS评分均低于对照组,差异显著(P<0.05).结论:急性脑梗塞介入治疗具有良好的近期疗效,有助于促进患者神经功能恢复,且预后效果理想,值得临床推荐.