全文获取类型
收费全文 | 20112篇 |
免费 | 1167篇 |
国内免费 | 182篇 |
专业分类
耳鼻咽喉 | 133篇 |
儿科学 | 1169篇 |
妇产科学 | 294篇 |
基础医学 | 2454篇 |
口腔科学 | 347篇 |
临床医学 | 1209篇 |
内科学 | 3442篇 |
皮肤病学 | 396篇 |
神经病学 | 1293篇 |
特种医学 | 693篇 |
外国民族医学 | 5篇 |
外科学 | 2765篇 |
综合类 | 791篇 |
一般理论 | 1篇 |
预防医学 | 1405篇 |
眼科学 | 1063篇 |
药学 | 2019篇 |
5篇 | |
中国医学 | 307篇 |
肿瘤学 | 1670篇 |
出版年
2022年 | 225篇 |
2021年 | 407篇 |
2020年 | 273篇 |
2019年 | 301篇 |
2018年 | 365篇 |
2017年 | 294篇 |
2016年 | 363篇 |
2015年 | 409篇 |
2014年 | 588篇 |
2013年 | 773篇 |
2012年 | 1110篇 |
2011年 | 1130篇 |
2010年 | 665篇 |
2009年 | 538篇 |
2008年 | 931篇 |
2007年 | 944篇 |
2006年 | 879篇 |
2005年 | 840篇 |
2004年 | 754篇 |
2003年 | 757篇 |
2002年 | 706篇 |
2001年 | 616篇 |
2000年 | 634篇 |
1999年 | 568篇 |
1998年 | 242篇 |
1997年 | 221篇 |
1996年 | 195篇 |
1995年 | 183篇 |
1994年 | 144篇 |
1993年 | 153篇 |
1992年 | 361篇 |
1991年 | 387篇 |
1990年 | 347篇 |
1989年 | 389篇 |
1988年 | 293篇 |
1987年 | 305篇 |
1986年 | 245篇 |
1985年 | 268篇 |
1984年 | 233篇 |
1983年 | 207篇 |
1982年 | 128篇 |
1981年 | 115篇 |
1979年 | 187篇 |
1978年 | 123篇 |
1977年 | 106篇 |
1975年 | 134篇 |
1974年 | 143篇 |
1973年 | 136篇 |
1972年 | 123篇 |
1971年 | 142篇 |
排序方式: 共有10000条查询结果,搜索用时 156 毫秒
41.
42.
43.
G H Rao V John T D Hill J L Vennerstrom J G White T J Holmes 《Thrombosis research》1986,44(4):527-538
The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carboxyl function into the alpha-ring, which should enhance binding according to proposed structural models for cyclooxygenase inhibitors, was not found to be beneficial. Increased structural rigidity, which resulted from covalent linkage of two aromatic rings in this series, did not eliminate anti-aggregatory properties. 相似文献
44.
The interaction between calmodulin and iodothyronines and the effect of iodothyronines on the calmodulin activation of cyclic AMP phosphodiesterase were investigated. Binding of [L-125I]triiodothyronine to calmodulin from pig brain, studied by equilibrium dialysis, was dependent on Ca2+, was saturable and reversible, with an apparent Kd of 2.79 microM and binding capacity of 0.5 nmol/20 micrograms of calmodulin L- and D-thyroxine, D-triiodothyronine and tetrac displaced [L-125I]triiodothyronine at concentrations of 8-10 microM; triac, 3,3'-diiodothyronine and reverse-triiodothyronine were weak displacers. In the presence of the antipsychotic drug trifluoperazine, binding decreased in a dose-related manner. Ultraviolet irradiation of calmodulin in the presence of trifluoperazine reduced the binding of [L-125I]triiodothyronine to calmodulin irreversibly. Calmodulin activation of cyclic AMP phosphodiesterase decreased when iodothyronines were bound to calmodulin; the calmodulin-L-triiodothyronine complex was the most active among the stereoisomers of thyroxine and triiodothyronine. These results suggest that, when triiodothyronine was bound to Ca2+-calmodulin, the activation of cyclic AMP phosphodiesterase by the latter is suppressed. 相似文献
45.
Devi Kanikanti Padmalatha Rao Kanikanti V. Ranga Baveja Srikrishan Fathi Marc Roth Marc 《Pharmaceutical research》1989,6(4):313-317
Zero-order release of oxprenolol hydrochloride was obtained by controlling the swelling and erosion of the matrix. This formulation involves only mixing of drug, hydroxypropylmethylcellulose (HPMC), and sodium carboxymethylcellulose (Na CMC) at the ratio of 1:0.4:1.6, respectively, and compressing the mixture directly into tablets. The in vitro release pattern from this optimized matrix tablet was reproducible. Accelerated stability studies revealed that the optimized formulation remains stable for an approximately 2-year shelf life. This sustained-release (SR) tablet was evaluated in dogs, and for comparison a conventional (CV) formulation was also given at the same dose level. Plasma oxprenolol levels were monitored by a sensitive and specific high-performance liquid chromatographic (HPLC) method. Significant differences in the pharmacokinetic parameters, i.e., lower C
max, higher values of t
max, MRT, AUC, and plasma concentration at 24 hr, and nearly constant plasma levels over 12 hr, indicated that the SR matrix tablet is superior to the CV rapid-releasing formulation. The in vitro release parameters and in vivo pharmacokinetics correlated well. 相似文献
46.
47.
48.
U A Nayak A P Rao D K Sugumaran Sundaram A L Meenakshi 《Indian journal of dental research》2005,16(1):27-31
Lobster-Claw syndrome is a rare autosomal dominant, hand-foot malformation with Oro-dental features. This is a rare condition and from the available reports so far, cases being reported are less than 1%. Most reports have focused on the hand-foot deformity of this syndrome. This paper highlights the typical Oro-dental features associated with this syndrome such as retained deciduous teeth, hypodontia and variation in crown size, arch length and arch width. 相似文献
49.
50.
Immunohistochemical identification of tissue factor in solid tumors. 总被引:25,自引:0,他引:25
Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound lipoprotein that functions as a cofactor to factor VIIa in the initiation of the extrinsic pathway of blood coagulation, has been postulated as a possible mechanism. Whereas the distribution of TF in normal tissues is known, no large survey of TF expression in malignant tissues has been reported. In this study a polyclonal, monospecific rabbit anti-human TF IgG was used for immunohistochemical localization of TF antigen in 85 different tumor specimens. In general, cell types which normally express TF continued to do so after malignant transformation (41 of 60 epithelial tumor specimens were positive for TF). Tumors of nonepithelial origin frequently lacked TF, with only 3 of 19 specimens containing evidence of TF antigen. In addition five of six benign tumors did not express TF. Many tumor types commonly associated with Trousseau syndrome, for example lung, pancreatic, breast, colon and gastric carcinomas, stained positively for TF. Based on this survey, it appears that TF expression by tumors may be an important factor in the pathogenesis of a hypercoagulable state in some patients with cancer. 相似文献