全文获取类型
收费全文 | 11705篇 |
免费 | 590篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 144篇 |
儿科学 | 288篇 |
妇产科学 | 231篇 |
基础医学 | 1717篇 |
口腔科学 | 409篇 |
临床医学 | 1113篇 |
内科学 | 2461篇 |
皮肤病学 | 191篇 |
神经病学 | 1247篇 |
特种医学 | 182篇 |
外科学 | 1027篇 |
综合类 | 43篇 |
一般理论 | 5篇 |
预防医学 | 1319篇 |
眼科学 | 106篇 |
药学 | 978篇 |
中国医学 | 67篇 |
肿瘤学 | 824篇 |
出版年
2024年 | 15篇 |
2023年 | 100篇 |
2022年 | 252篇 |
2021年 | 446篇 |
2020年 | 278篇 |
2019年 | 377篇 |
2018年 | 402篇 |
2017年 | 291篇 |
2016年 | 292篇 |
2015年 | 343篇 |
2014年 | 521篇 |
2013年 | 644篇 |
2012年 | 1007篇 |
2011年 | 1052篇 |
2010年 | 516篇 |
2009年 | 476篇 |
2008年 | 755篇 |
2007年 | 805篇 |
2006年 | 673篇 |
2005年 | 654篇 |
2004年 | 600篇 |
2003年 | 508篇 |
2002年 | 468篇 |
2001年 | 57篇 |
2000年 | 56篇 |
1999年 | 66篇 |
1998年 | 91篇 |
1997年 | 75篇 |
1996年 | 50篇 |
1995年 | 48篇 |
1994年 | 48篇 |
1993年 | 39篇 |
1992年 | 34篇 |
1991年 | 28篇 |
1990年 | 26篇 |
1989年 | 16篇 |
1988年 | 19篇 |
1987年 | 20篇 |
1986年 | 17篇 |
1985年 | 23篇 |
1984年 | 19篇 |
1983年 | 16篇 |
1982年 | 20篇 |
1981年 | 13篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1978年 | 9篇 |
1976年 | 7篇 |
1974年 | 7篇 |
1973年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 13 毫秒
41.
42.
43.
Letizia Mazzini Daniela Testa Carla Balzarini Gabriele Mora 《Journal of neurology》1994,241(4):223-227
Based on the hypothesis that free radicals play a general role in the neurodegenerative process in motor neuron disease, we tested selegiline in a group of patients affected by amyotrophic lateral sclerosis (ALS) to examine whether it might modify the progression of the disease. Patients were admitted if they were 25–80 years old and had a confirmed diagnosis of ALS with symptoms lasting no longer than 24 months. Patients with familial ALS, pure progressive bulbar palsy, primary lateral sclerosis or progressive muscle atrophy were excluded; a total of 111 patients were recruited. Fifty-three patients were randomly assigned to receive the drug (selegiline 10 mg/day orally for 6 months) and the remaining 58 were considered ALS controls. Mortality was similar in the two groups (4 and 5 patients respectively), though the difference was not statistically significant. Among the survivors, mean MRC and Norris disability scores and forced vital capacity were fairly similar in the two groups at all times and no statistically significant difference between treated and untreated patients was found. The results did not change when the data were related to age, duration and characteristics of onset of the disease. The rate of progression was significantly more rapid in patients with bulbar symptoms in both groups. Our data do not show any significant effect of selegiline in modifying the progression of ALS. 相似文献
44.
Pam McGrath Carla Patterson Patsy Yates Sue Treloar Brian Oldenburg Colleen Loos 《The Australian journal of rural health》1999,7(1):34-42
The findings presented in this paper are part of a research project designed to provide a preliminary indication of the support needs of postdiagnosis women with breast cancer in remote and isolated areas in Queensland. This discussion will present data that focuses on the women's expressed personal concerns. For participants in this research a diagnosis of breast cancer involves a confrontation with their own mortality and the possibility of a reduced life span. This is a definite life crisis, creating shock and needing considerable adjustment. Along with these generic issues the participants also articulated significant issues in relation to their experience as women in a rural setting. These concerns centred around worries about how their partner and families cope during their absences for treatment, the additional burden on the family of having to cope with running the property or farm during the participant's absence or illness, added financial strain brought about by the cost of travel for treatment, maintenance of properties during absences, and problems created by time off from properties or self-employment. These findings accord with other reports of health and welfare services for rural Australian and the generic literature on psycho-oncology studies of breast cancer. 相似文献
45.
p53 Accumulation Is a Prognostic Factor in Intestinal-Type Gastric Carcinoma but Not in the Diffuse Type 总被引:2,自引:0,他引:2
Roviello F Marrelli D Vindigni C De Stefano A Spina D Pinto E 《Annals of surgical oncology》1999,6(8):739-745
Background: The prognostic value of p53 nuclear accumulation in gastric cancer is still unclear, as shown by the discordant results still reported in the literature. In this study, we evaluated the correlation between p53 accumulation and long-term survival of patients resected for intestinal and diffuse-type gastric cancer.Methods: Eighty-three patients with carcinoma of the intestinal type and 53 patients with carcinoma of the diffuse type were included in the study. Immunohistochemical staining of the paraffin sections was performed by using monoclonal antibody DO1; cases were considered positive when nuclear immunostaining was observed in 10% or more of the tumor cells. Prognostic significance of different variables was investigated by univariate and multivariate analysis.Results: p53 positivity was found in 51.8% of intestinal-type and 50.9% of diffuse-type cases. No significant correlation between the rate of p53 overexpression and age, sex, tumor location, tumor size, depth of invasion, lymph node involvement, distant metastases, and surgical radicality was found in the two groups of patients. A statistically significant difference in survival rate was observed between p53-negative and p53-positive cases in the intestinal type (P < .05), confirmed by multivariate analysis (P < .005; relative risk = 3.09). On the contrary, no correlation with survival was found in diffuse-type cases according to p53 overexpression.Conclusions: These results suggest that the immunohistochemical detection of p53 accumulation is a useful indicator of poor prognosis in the intestinal but not in the diffuse type of gastric cancer, and are indicative of distinct molecular pathways and pattern of progression in the two histotypes. 相似文献
46.
47.
48.
49.
Susi Burgalassi Daniela Monti Annalisa Brignoccoli Ortenzio Fabiani Carla Lenzi Andrea Pirone Patrizia Chetoni 《Journal of ocular pharmacology and therapeutics》2004,20(6):518-532
The aim of this study was to prepare and test an artificial corneal epithelium (reconstituted rabbit corneal epithelium, RRCE) exhibiting barrier characteristics and paracellular permeability similar to those of native rabbit cornea. The RRCE was obtained from a rabbit corneal epithelium (RCE) cell line grown for 8 days in submerged culture, then for 7 days in air-interface conditions on Snapwell polyester membranes. Permeation studies on the RRCE were carried out in comparison with rabbit excised corneas in vitro, using timolol maleate (TM) as the test drug, alone and in association with the following ocular permeation enhancers: benzalkonium chloride, ethylene-diaminetetraacetic acid sodium salt, polyethoxylated castor oil, polyoxyethylene stearyl ether, sodium deoxycholate, and escin. The integrity of the RRCE was assessed by measuring the transepithelial electrical resistance (TEER) during culture time and after every permeation experiment. When TM was tested alone, the permeation parameters (apparent permeability coefficient, lag time) obtained with the RRCE were similar to those of excised rabbit corneas. The artificial epithelium, however, was less sensitive than native cornea to the effect of permeation enhancers. 相似文献
50.
Simon P. Jochems Karin de Ruiter Carla Solrzano Astrid Voskamp Elena Mitsi Elissavet Nikolaou Beatriz F. Carniel Sherin Pojar Esther L. German Jesús Rein Alessandra Soares-Schanoski Helen Hill Rachel Robinson Angela D. Hyder-Wright Caroline M. Weight Pascal F. Durrenberger Robert S. Heyderman Stephen B. Gordon Hermelijn H. Smits Britta C. Urban Jamie Rylance Andrea M. Collins Mark D. Wilkie Lepa Lazarova Samuel C. Leong Maria Yazdanbakhsh Daniela M. Ferreira 《The Journal of clinical investigation》2022,132(11)